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Microsoft word - arthritiden

Arthritiden und Fibromyalgie
Nichtrheumatoide Arthritis, "Seronegative Arthritis"
Gonokokken, Chlostridien, Salmonellen, Staphylokokken, Haemophilus influenza, Mykobakterien,
Nocardien, Streptokokken, Corynebakterien, Kristallablagerungen (Urea, Hydroxyapatit)
Rheumatoide Arthritis, "Seropositive Arthritis"
Listeria-ähnliche Cell Wall Defective Forms, Mykoplasmen, Virusarten, Propionibacterium acnes,
Erysipelotrix rhusiopathiae,
Road Back Foundation
Mattman LH (2001) Cell Wall Deficient Forms. Stealth Pathogens. CRC Press

Schüller M, II, (1893) Untersuchungen über die Ätiologie der sogen. Chronisch-rheumatischenGelenkentzündungen. Berl. Klin. Wochenschr. 30, 865-868 Bannatyne GA, Wohlmann AS, Blaxall RF (1896) Rheumatoid arthritis: its clinical history, etiology, andpathology. Lancet 1, 1120-1125 Schüller MV (1900) Polyarthritis villosa und Arthritis deformans. Berl. Klin. Wochenschr. 124-128 Warren SK, Marmor L, Liebes DM et al (1969) An active agent from human rheumatoid arthritis
with ist transmissible in mice
. Arch. Intern. Med. 124, 629-634
Warren SK, Marmor L, Liebes DM et al (1969) Congenital transmission in mice of an active agent
from human rheumatoid arthritis
. Nature 223, 646-664
Cook J, Fincham WJ, Lack CH (1969) Chronic arthritis produced by streptococcsl L-Forms. J.
Pathol. 99, 283-297
Waitzkin L (1969) Latent Corynebacterium acnes infection of bone marrow. N. Engl. J. Med. 281,
1404-1405
Warren SK, Marmor L, Boak R et al. (1971) Transmission of an active agent from rheumatoid
arthritis synovial tissue to chicks
, Arch. Intern. Med. 128, 619-622
Fraser KB, Shirodaria PV, Haire M et al. (1971) Mycoplasmas in cell cultures from rheumatoid
synovial membranes. J. Hyg. 69, 17-25
Warren SK, Marmor L, Liebes DM et al. (1972) An active agent from rheumatoid arthritis synovial
tissue
. Arch. Intern. Med. 130, 899-903 "The agent in rheumatoid arthritis (RA) synovial tissue has been transmitted from individual patients to
normal mice and rats by injection or ingestion. There was a variation in degree of the severity of the
characteristic acute lesions in mice induced by the tissue of each individual patient. Similar characteristic
lesions were induced in the same manner from RA-affected mouse and rat tissues. Neither injection nor
ingestion of normal tissues induced lesions".

Barthelemew LE, Nelson FR (1972) Corynebacterium acnes in rheumatoid arthritis. Ann. Rheum.
Dis. 31, 28-33
Crocker JFS, Ghose T, Rozee K et al. (1974) Arthritis, deformities, and runting in C5-deficient miceinjected with human rheumatoid arthritis synovium. J. Clin. Path. 27, 122-124 Warren SK, Marmor L, Stamm ME et al. (1975) Thermal inactivation and gradient studies of the active
agent in rheumatoid arthritis
. Rheumatology 6, 361-367
Schumacher HR, Jr. (1975) Synovial membrane and fluid morphologic alterations in early rheumatoid
arthritis: microvascular injury and virus-like particles. Ann. N.Y. Acad. 256, 39-64
LeBar WD, Mattman LH, Ross L (1975) Isolation of cell wall deficient Mycobacterium tuberculosis
from a case of chronic arthritis. Henry Ford Hosp. Med. J. 23, 17-20
Wagner R (1976) Bakterieller Einfluss auf Autoimmunreaktionen bei Rheumatoider Arthritis:
Suche nach kreuzreaktiven Antikörpern und Beitrag von Superantigenen bei induzierter Arthritis in der
Maus. Dissertation Friedrich-Schiller –Universität Jena.
Godzeski CW, Boyd R, Snith CA et al (1978) Viral-like particles in cocultivated rheumatoid synovial
cells. Arthrit. Rheum. Abstr. 21, 559
Warren SK, Marmor L, Horner HE et al. (1979) Further studies on the specific infectious agent
isolated in rheumatoid arthritis
. J. Rheumatol. 6, 135-146
Warren SK, Marmor L, Gerken SC et al. (1979) Correlation of a bioassay with the clinical status ofpatients with rheumatoid arthritis. Clin. Orthopaed. 144, 299-304 Denys GA (1981) Characteristics of wall deficient and classical forms of Propionibacterium acnes
from rheumatoid arthritis
. Ph. D. dissertation, Wayne State University, Detroit.
Simpson RW, McGinty L, Simon L et al. (1984) Association of parvoviruses with rheumatoid
arthritis of humans
. Science 233, 1425-1428
Cohen BJ, Buckley MM, Clewley JP et al (1986) Human parvovirus infection in early rheumatoid
and inflammatory arthritis
. Ann. Rheum. Dis. 45, 832-838
Dr. Brown (1988) Explaining his Antibiotic Protocol for Rheumatic Diseases.
Wirostko E, Johnson L, Wirostko W et al. (1989) Juvenile rheumatoid arthritis inflammatory eye
disease. Parasitization of ocular leucocytes by mollicute-like organisms. J. Rheumatol. 16, 1446-
1453. "This report describes MLO parasitized lesional leukocytes in the inflammatory eye disease of 5 patients
with JRA. Our results indicate that MLO caused the uveitis of these patients. The significance of these
findings and rifampin treatment of MLO disease are discussed".

Fraser DD, Kong LI, and Miller FW (1992) Molecular detection of persistent Borrelia burgdorferi in a
man with dermatomyositis. Clinical and Experimental Rheumatology 10, 387-390.
Lovy MR, Starkebaum G, Uberoi S (1996). Hepatitis C infection presenting with rheumatic
manifestations: a mimic of rheumatoid arthritis. J. Rheumatol 23 (6), 1238–9.
Wollenhaupt J, Sieper J (1997) Erreger- und Infektorientierte Differentialdiagnostik der reaktiven
Arthritiden.
Microbiological Procedures for the Diagnosis of Reactive Arthritis. Akt Rheumatol 22(5),
191-197 DOI: 10.1055/s-2008-1043655. Georg Thieme Verlag KG Stuttgart · New York
Takahashi Y, Muray C, Shibata S et al. (1998) Human Parvovirus B19 as a causative agent for
rheumatoid arthritis
. Proc. Natl. Acad. Sci. USA, 7, 95(14), 8227-8232
Scharrr S, A Wahl, B Jurgens-Saathoff, M Mengel, HH Kreipe, Zeidler H (2002) Nodular fasciitis,
erythema migrans, and oligoarthritis: manifestations of Lyme borreliosis caused by Borrelia afzelii.
Scan J Rheumatol 31, 184-186.
Leirisalo-Repo M, Hannu T, Mattila L (2003) Microbial factors in spondyloarthropathies: insights
from population studies. Curr Opin Rheumatol. 15, 408–12.
(2003) Therapeutic strategies for rheumatoid arthritis. 2(6), 473-88.
Balandraud N, Roudier J, Roudier C (2004) Epstein-Barr virus and rheumatoid arthritis.
Autoimmun Rev 3 (5), 362–7.
Zeidler H, Kuipers J, Kohler L (2004) Chlamydia-induced arthritis. Curr Opin Rheumatol. 16, 380–92.

Alvarez-Lafuente R, Fernández-Gutiérrez B, de Miguel S et al. (2005). Potential relationship between
herpes viruses and rheumatoid arthritis: analysis with quantitative real time polymerase chain
reaction. Ann. Rheum. Dis. 64 (9), 1357–9. "Herpes viruses may have a role in RA, although alternative explanations are possible: (a) defects in
cellular immunity in patients with RA may result in a relatively high viral load; (b
) patients with RA may be
more prone to infection/reactivation. The usefulness of monitoring the DNA viral load in patients with RA
is questioned by these data".

Hsieh Y-F, Liu H-W, Hsu T-Ch et al. (2007) Serum Reactivity against Borrelia burgdorferi OspA in
Patients with Rheumatoid Arthritis. CLINICAL AND VACCINE IMMUNOLOGY American Society for
Microbiology. 14(11), 1437–1441.
(2009) Clinical guideline for the diagnosis and management of early rheumatoid arthritis. The Royal
Australian College of General Practitioners College House 1 Palmerston Crescent South Melbourne,
Victoria 3205, Australia
Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. Lancet 376 (9746), 1094–108.
Wen H, Baker JF (2011) Vitamin D, immunoregulation, and rheumatoid arthritis. Journal of clinical
rheumatology : practical reports on rheumatic & musculoskeletal diseases 17 (2), 102–7.
Poehlmann KE (1997 Dissertation, 4. Auflage 2012) Rheumatoid Arthritis: The Infection
Connection
. Sarori Press.
Soeken, K L; Miller, S A; Ernst, E.(2013) Herbal medicines for the treatment of rheumatoid arthritis: a
systematic review. Retrieved.
HB, P, J et al. (2013) Does nuclear tissue infected with bacteria following discherniations lead to Modic changes in the adjacent vertebrae? European Spine Journal 22, 690-696 HB, JS, BSch, C (2013) Antibiotic treatment in patients
with chronic low back pain and vertebral bone edema
(Modic type 1 changes): a double-blind
randomized clinical controlled trial of efficacy. European Spine Journal 22, 697-707

Schneide M, Krüger K (2013) Rheumatoid arthritis – early diagnosis and disease management.
Dtsch Ärztebl 110(27-28), 477-484
, (2013) Excessive Peptidergic Sensory
Innervation of Cutaneous Arteriole-Venule Shunts (AVS) in the Palmar Glabrous Skin of
Fibromyalgia Patients: Implications for Widespread Deep Tissue Pain and Fatigue. Pain Med. 14(6),
895-915. doi: 10.1111/pme.12139.
Ogrendik M (2013) Antibiotics for the treatment of rheumatoid arthritis. International Journal of
General Medicine. Volume 2014:7 Pages 43 – 47 DOI: http://dx.doi.org/10.2147/IJGM.S56957
„Antibiotic treatment for rheumatoid arthritis (RA) commenced in the 1930s with the use of sulfasalazine.
Later, tetracyclines were successfully used for the treatment of RA. In double-blind and randomized
studies, levofloxacin and macrolide antibiotics (including clarithromycin and roxithromycin) were also
shown to be effective in the treatment of RA."

Ogrendik M (2013) Rheumatoid arthritis is an autoimmune disease caused by periodontal pathogens.
International Journal of General Medicine 2013(6), 383 – 386 "The most analyzed species of periodontopathic bacteria are Porphyromonas gingivalis, Prevotella
intermedia,
Tannerella forsythia, and Aggregatibacter actinomycetemcomitans."
, et al. (2013) Expansion of intestinal Prevotella copri
correlates with enhanced susceptibility to arthritis.
2, e01202. doi: 10.7554/eLife.01202.

, , . (2014) Exposure to mimiviruscollagen promotes arthritis. 88(2), 838-45. doi: 10.1128/JVI.03141-13. Epub 2013 Oct 30.
Kumar A (2014) How to investigate new-onset polyarthritis. ), 844–859
, (2015) Decreased bacterial diversity characterizes the altered gut
microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel
disease.
67(1), 128-39. doi: 10.1002/art.38892.

Markowicz M, Ladstätter S, Schötter AM et al (2015) Oligoarthritis Caused by Borrelia bavariensis,
Austria, 2014
. CDC EID journal 21(6)
Zeana C, et al. (2016) Post-chikungunya rheumatic disorders in travelers after return from the
Caribbean,
Travel Medicine and Infectious Disease
M, S, aM et al. (2015) Oligoarthritis Caused
by Borrelia bavariensis, Austria, 2014.
21(6), 1052–1054. doi:
PMCID: PMC4451909

Angiopathie, Vasculitis Zahn-und Mundpflege Alzheimer Multiple Sklerose Borrelien, Vasculitis, Inflammation, Lymphom, Neoplasma
Tetracycline bei Rheumatioder Arthritis
A T , L , J, LM , T (1995) Tetracyclines in treatment ofrheumatoid arthritis. The Lancet, 645 - 646 ROAD BACK FOUNDATION Neergaard L (2002) Rheumatoid-Arthritis Drug Found. Associated Press , . (2003) Should tetracycline treatment be used moreextensively for rheumatoid arthritis? Metaanalysis demonstrates clinical benefit with reduction indisease activity. J Rheumatol. 30(10), 2112-22 "Tetracyclines, in particular minocycline, were associated with a clinically significant improvement in
disease activity in RA with no absolute increased risk of side effects."
Skinner M, Cathcart ES, Mills JA, Pinals RS (2005) Tetracycline in the treatment of rheumatoidarthritis. A double blind controlled study. Arthritis & Rheumatism pages 727–732, Fleischmajer R (2006) Tetracyclines: nonantibiotic properties and their clinical implications. In: Journal
of the American Academy of Dermatology. Band 54, Nummer 2, 258–265, .
. (Review)
Adwan MHQ (2009) Tetracycline Antibiotics for Treating Rheumatoid Arthritis: A Systematic Review
and Meta-Analysis. Arthritis & Rheumatism, Volume 60, October 2009 Abstract Supplement
"Tetracycline antibiotics may be potentially effective and reasonably safe in rheumatoid arthritis."
Smith A, Doré C, Charles P, Vallance A, Potier T, Mackworth-Young C (2011) Randomised Double-
Blind Trial of Combination Antibiotic Therapy in Rheumatoid Arthritis. Research Article. International
Journal of Rheumatology Volume 2011, Article ID 585497, 6 pages
"This antibiotic regime is unlikely to be a valuable therapy for active rheumatoid arthritis."
CJ, H, TR, K (2011) rthritis research & therapy 13(5), R168
"Rheumatologists have not embraced minocycline or doxycycline as primary treatment options for RA
and reserve their use primarily in patients with long-standing, refractory disease. These drugs are
generally well tolerated, with skin complaints, nausea, and dizziness being the most common patient-
reported side effects."

, , . (2013) Antibiotic treatment in patients withchronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomizedclinical controlled trial of efficacy. 22(4), 697-707. doi: 10.1007/s00586-013-2675-y.
"The antibiotic protocol in this study was significantly more effective for this group of patients (CLBP
associated with Modic I) than placebo in all the primary and secondary outcomes."

Tetrazykline
"Biologicals", Risiken, riscs
, (2005) Infections in patients with rheumatoid arthritis treated with
biologic agents.
52(11), 3403-12. DOI 10.1002/art.21386

American College of Rheumatology (2010) Biologic Treatments for Rheumatoid Arthritis.

F (2011) Choice of Biologic Therapy for Patients with Rheumatoid Arthritis: The
Infection Perspective.
Curr Rheumatol Rev. 7(1), 77–87. doi: PMCID: PMC3182090
Deutsche Rheuma-Liga (2012) Basismedikamente.
Cush JJ (2013) Prevention and Management of Serious Infections with Biologic Use in
Rheumatoid Arthritis. DSQ 4(4)

Dixon WG (2015) Rheumatoid arthritis: biological drugs and risk of infection. The Lancet.
„The authors conclude: "This new knowledge, when balanced against the clinically important benefits of
biological drugs, will help patients and their physicians to make evidence-based decisions that align with
their values, preferences, and tolerance of risks of harm and benefits." - See more at:

Kombination von Antibiotika und Immunsuppressiva. Combination of
antibiotics and immunosuppressants

, , (2013) Clarithromycin in rheumatoid arthritis: the addition to methotrexate and low-dose
methylprednisolone induces a significant additive value-a 24-month single-blind pilot study.
Rheumatol Int. [Epub ahead of print]
Immunsuppression Standard antimicrobiotics
, 2012. Letzte Revision Februar 2016 Back to top:

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