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Bariatric Surgical and Procedural
in the Treatment of Obese Patients
with Type 2 Diabetes
A position statement from the
International Diabetes Federation Taskforce
on Epidemiology and Prevention
Table of Contents
1. EXECUTIVE SUMMARY . 1
2. BACKGROUND . 3
Why is this position statement needed? . 3 How is obesity defined? . 4 What is the link between obesity and type 2 diabetes? . 6 Negative attitudes toward obesity . 7 Why should bariatric surgery be considered in algorithms for treating obese type 2 diabetes? . 8 Evolving concepts: "Bariatric-Metabolic Surgery" and "Interventional Diabetology" . 10 Is bariatric surgery for severe obesity an effective treatment for type 2 diabetes? . 10 Are there other benefits from bariatric surgery for persons with type 2 diabetes? . 12 Is bariatric surgery cost-effective for the obese person with type 2 diabetes? . 13 What eligibility guidelines already exist on bariatric surgery for type 2 diabetes? . 15 2.10.1 Recommendations for Adolescents . 16 Do bariatric procedures vary in their effectiveness? . 17 What are the risks of bariatric surgery? . 19 What are the components of successful bariatric surgery? . 21 Which patients with type 2 diabetes should be considered for bariatric surgery? . 23 Should bariatric surgery be integrated into diabetes treatment algorithms? .24 Is there equitable access to bariatric surgery? . 25 What is a successful outcome of bariatric surgery for a person with type 2 diabetes? . 25 Novel extra-luminal and endo-luminal procedures and devices and novel bariatric metabolic devices . 26 2.18.1 Novel extra-luminal and endo-luminal procedures and devices . 26 2.18.2 Novel bariatric metabolic devices . 27 3. RECOMMENDATIONS . 29
Management of Diabetes . 29 Research Recommendations . 30 4. IDF CONSENSUS PANEL . 32
5. REFERENCES . 35
1. The classification of weight category by BMI . 6
2. 2 & 10 year diabetes incidence and remission rates from the Swedish Obese Subjects
3. Mortality hazard ratios for white non-smokers . 12
4. Cost effectiveness of bariatric procedures in people with diabetes . 14
5. National and international guidelines for eligibility for bariatric surgery (adults) . 15
6. Estimated weight loss and percentage of those with diabetes who remit at two years
after conventional bariatric procedures (Systematic review (Buchwald et al)) . 17 7. Patient and program factors associated with risk of surgery . 19
8. A summary of more common nutritional concerns for each procedure . 21
9. Eligibility and prioritization for bariatric surgery based on failed non-surgical weight
loss therapy*, BMI, ethnicity** and disease control . 24 Executive Summary
Obesity and type 2 diabetes are serious chronic diseases associated with complex metabolic dysfunctions that increase the risk for morbidity and The dramatic rise in the prevalence of obesity and diabetes has become a major global public health issue and demands urgent attention from governments, health care systems and the medical community. Continuing population-based efforts are essential to prevent the onset of obesity and type 2 diabetes. At the same time, effective treatment must also be available for people who have developed type 2 diabetes Faced with the escalating global diabetes crisis, health care providers require as potent an armamentarium of therapeutic interventions as possible. In addition to behavioural and medical approaches, various types of surgery on the gastrointestinal tract, originally developed to treat morbid obesity ("bariatric surgery"), constitute powerful options to ameliorate diabetes in severely obese patients, often normalising blood glucose levels, reducing or avoiding the need for medications and providing a potentially cost-effective approach to treating the disease. Bariatric surgery is an appropriate treatment for people with type 2 diabetes and obesity not achieving recommended treatment targets with medical therapies, especially when there are other major co-morbidities. Surgery should be an accepted option in people who have type 2 diabetes and a BMI of 35 or more Surgery should be considered as an alternative treatment option in patients with a BMI between 30 and 35 when diabetes cannot be adequately controlled by optimal medical regimen, especially in the presence of other major cardiovascular disease risk factors. In Asian, and some other ethnicities of increased risk, BMI action points may be reduced by 2.5 kg/m2. Clinically severe obesity is a complex and chronic medical condition. Societal prejudices about severe obesity, which also exist within the health care system, should not act as a barrier to the provision of clinically effective and cost-effective treatment options. Strategies to prioritise access to surgery may be required to ensure that the procedures are available to those most likely to benefit. Available evidence indicates that bariatric surgery for obese patients with type 2 diabetes is cost-effective. Bariatric surgery for type 2 diabetes must be performed within accepted international and national guidelines. This requires appropriate assessment for the procedure and comprehensive and ongoing multidisciplinary care, patient education, follow-up and clinical audit, as well as safe and effective surgical procedures. National guidelines for bariatric surgery in people with type 2 diabetes and a BMI of 35 or more need to be developed and The morbidity and mortality associated with bariatric surgery is generally low, and similar to that of well-accepted procedures such as elective gall bladder or gall stone surgery. Bariatric surgery in severely obese patients with type 2 diabetes has a range of health benefits, including a reduction in all-cause mortality. A national registry of persons who have undergone bariatric surgery should be established in order to ensure quality patient care and to monitor both short- and long-term outcomes. In order to optimise the future use of bariatric surgery as a therapeutic modality for type 2 diabetes further research is required. Background
Why is this position statement needed?
The global prevalence of type 2 diabetes is rising dramatically, driven by an "obesogenic" environment that favours increasing sedentary behaviour and easier access to attractive calorie-dense foods acting on susceptible genotype The most recent global predictions by the International Diabetes Federation (IDF) suggest that there are 285 million people with diabetes currently worldwide. This is set to escalate to 438 million by 20with a further half billion at high risk. Diabetes is looming as one of the greatest public health threats of the 21st century. Type 2 diabetes is a risk factor for vascular damage: both micro-vascular (retinopathy; nephropathy and neuropathy) and macro-vascular (premature and more extensive cardio- , cerebro- and peripheral vascular disease). Premature mortality and morbidity in diabetes result from such complications. The disease results from inadequate insulin production and action and results in hyperglycaemia but is also associated with multiple other dysfunctions involving lipid metabolism; oxidative stress; inflammation and haemato-rheology. In addition obesity, by itself, generates similar cardio-metabolic dysfuncti The dramatic rise in the prevalence of obesity and diabetes has become a major global public health i The problem is compland will require strategies at many levels to prevent, control and manage. There is increasing evidence that the health of obese people with type 2 diabetes, including the metabolic control of diabetes and its associated risk factors, can benefit substantially from bariatric surgery – that is, surgical procedures to produce substantial weight l Several gastrointestinal (GI) operations that were originally designed to treat morbid obesity also cause dramatic improvement of type 2 diabetes and can effectively prevent progression from impaired glucose tolerance to diabetes in severely obese individual In addition, bariatric surgery has been shown to substantially improve hypertension, dyslipidaemia and sleep apnoand several reports have documented an improvement of overall survivand specific reduction in diabetes-related mortalit Despite a number of evidence-based reviews and consensus statements having been published regarding the utilisation of bariatric surgery in patients with obesity and diabthe International Diabetes Federation (IDF) has not previously considered this rapidly developing area of care for world-wide use. Therefore a need exists for world-wide expert guidance in the preoperative evaluation, choice of interventional procedure, perioperative management and long-term care of patients who seek surgery to improve diabetes control. The IDF Taskforce on Epidemiology and Prevention convened a Consensus working group of diabetologists, endocrinologists, surgeons and public health experts in December 2010 to discuss the appropriate role of bariatric surgery and other gastrointestinal interventions in the treatment and prevention of obesity and type 2 diabetes. The specific goals of the panel were: to develop practical recommendations for clinicians to identify barriers that currently prevent access to surgery and suggest interventions for health policy changes that ensure equitable access to surgery when indicated. to identify priorities for clinical research This consensus statement considers primarily established bariatric surgical procedures. It is acknowledged that this is an emerging field and there is a large range of novel extraluminal and endoluminal gastrointestinal surgical procedures and devices that are in the development phase. Some focus primarily on weight loss and others additional non-weight loss metabolic benefits. The use of these require further validation before they can be 2.2
How is obesity defined?
Obesity is usually classified by body mass index (BMI), calculated as body weight in kilograms divided by the height in metres squared (kg/m2). Classifications of BMI, as defined by WHO, based on associations with adverse health consequences, are listed in Table 1. Other methods, including waist circumference and central and peripheral fat mass, have also been used but currently the clearest evidence suggests continued use of BMI as an index of obesity, particularly when BMI exceeds 30 kg/m2. BMI categories have been developed primarily in populations of mainly European ethnicity, and often underestimate health risks in other populations. In addition, BMI does not necessarily reflect the proportion of body weight that consists of fat, or the distribution of fat: both these aspects of body composition can affect the health risks of excess weight. Nevertheless, at present, in the absence of a better alternative, BMI is the internationally accepted standard used by researchers and policy makers to allocate individuals to different size Clinically severe or "morbid" obesity is considered to be Class III obesity or Class II obesity with significant obesity related co-morbidity including type 2 diabetes (Table 1). Additional cut-points for public health action have been suggested to address the increased risk of diabetes and cardiovascular disease in Asian populations and further investigation should examine other at risk Table 1: The classification of weight category by BMI
Principal cut-off Cut-off points
Obese class III For Asian populations classifications remain the same as the international
classification but that public health action points for interventions are set at 23,
27.5, 32.5 and 37.
We address eligibility and prioritization for bariatric surgery within the coloured
Source: Adapted from WHO
What is the link between obesity and type 2 diabetes?
Type 2 diabetes is an heterogeneous disorder and, while its causes have yet to be fully explained, obesity is considered the primary risk facto It has been estimated that the risk of developing type 2 diabetes is increased 93-fold in women and 42-fold in men who are severely obese rather than of healthy weig A small proportion of people with type 2 diabetes, approximately 15% in populations of European origin, are not overweig In the short term, even modest weight loss in people with type 2 diabetes who are overweight or obese is associated with improvements in glycaemic control and associated conditions such as hypertension and dyslipida However, there is strong evidence that significant weight loss achieved by using lifestyle and medical methods by obese, particularly severely obese, people is modest and rarely sustained, particularly in the severely obeThere are now few medications approved for weight loss with recent withdrawals associated with 2.4
Negative attitudes toward obesity
There are widely held community attitudes that the majority of obese individuals are responsible for their current weight. Severe obesity is too often misconstrued as a „cosmetic‟ problem and a result of personal failure or lack of However, this perspective ignores the very strong genetic and developmental bases to severe obesitcompounded by physical, emotional and societal issues. It also fails to consider the pervasive obesity promoting effects of modern societies (the „obesogenic environment‟where an abundant food supply, changes in food preparation, increasing sedentary behaviour and other lifestyle factors mitigate against weight control for individuals. Additionally, it ignores the emerging evidence that body weight is defended by powerful physiological mechanismmaking long term maintenance of weight loss In the context of treatment, negative societal attitudes have been a barrier to the provision of clinically effective, and cost-effective, health care for people with severe obesity and type 2 diab As noted earlier, obesity is a consequences for health which requires a comprehensive approach to both prevention and treatment. People affected by severe obesity often struggle not only with the health and physical consequences of their chronic condition, but discrimination at work, socially and within the healthcare system. 2.5
Why should bariatric surgery be considered in algorithms for
treating obese type 2 diabetes?
Both insulin resistance and insulin secretory reserve are important in the pathogenesis of type 2 diabbut to different extents in different people. It is very important to recognise that not all type 2 diabetes is the same and it is currently difficult to match the different therapies available to different phenotypes often resulting to suboptimal responses to therapy. Type 2 diabetes is a progressive disease and the usual natural history is of progressive loss of insulin secretory capacity over time and the need for intensification of therapy and polypharm Arresting this progression is a formidable therapeutic challenge. Treatment for type 2 diabetes must also include active management of all cardiovascular risk factors (hypertension, dyslipidaemia, smoking and inactivity) but glycaemic control is very important – and not just for prevention of microvascular disease. Years of improved glycaemic control continue to deliver reduced risk of macrovascular disease and mortality over subsequent year Given the role of obesity in the aetiology of type 2 diabetes, guidelines on its treatment provide that weight loss, with its many benefits, should be the most logical and cost-effective means of controlling type 2 diab Lifestyle interventions to promote weight loss and increase physical activity should be included as an essential component of diabetes treatment regimens. Medical therapeutic options targeting primarily glucose control are all ideally added to, and not exchanged for, lifestyle change. Unfortunately, such strategies have very limited success in controlling blood glucose levels amongst the severely obese, with many of these patients not achieving targets. A number of these medications used for treating type 2 diabetes, including insulin, themselves can result in weight gain. A major problem for managing type 2 diabetes is the need for continuous monitoring and intensification of therapies by adding new agents in increasing doses over time. The ADA and EASD consensus statement recommends that an HbA1c of 7% is a call to acti Some national guidelines, such as those from UK‟s NIC support more vigorous intensification of glycaemic therapies in early stages of diabetes. NICE used HbA1c ≥ 6.5% to increase from monotherapy but ≥7% for increasing to triple therapies and beyond. This is very important. In one trial that randomised people with type 2 diabetes and existing cardiovascular disease to very intensive management targeting HbA1c <6.5%, mortality was higher in the intensive group, driven by deaths in those people who failed to show HbA1c improvement as treatment was intensifi This should not be taken to mean people with early type 2 diabetes should be treated less vigorously as the legacy effect of early intervention is A critical issue has been the rate at which health care professionals escalate therapies. Current approaches that rely on loss of glycaemic control and on intensifying lifestyle or other time consuming measures set clinicians up for failure to achieve target It may be possible to achieve much more in terms of complication prevention – or even possibly slowed rate of progression – if treatments are started and intensified early. There have even been suggestions of starting polypharmacy at diagnosibut there is limited current evidence to demonstrate the efficacy Apart from the side effect profiles and suboptimal deployment of existing medical diabetes therapies, there remain issues around patient engagement in many aspects of their lives. Very few clinical services routinely provide psychological support to encourage life-long engagement in self-care. The continuing morbidity and mortality in persons with diabetes is a sign that the answer as to the best management for type 2 diabetes in terms of maximising metabolic control is still elusive. Given this scenario, the option of bariatric intervention needs to be considered in appropriately selected 2.6
The term "bariatric" surgery, derived from the Greek word baros for weight, defines surgical procedures designed to produce substantial weight loss. Accordingly, goals of bariatric surgery originally evolved around achieving substantial sustained weight loss. In reality, weight loss is only one of the outcomes of such surgery. Bariatric surgery can be associated with substantial hyperglycaemia. hyperlipidaemia, blood pressure, obstructive sleep apnoea and improved quality of lif In view of the broad benefits of weight loss and the growing evidence that some bariatric procedures provide metabolic changes that cannot be explained completely by their effects on body weight alone, the name "bariatric- metabolic surgery" is emerging as a more appropriate name. 2.7
Is bariatric surgery for severe obesity an effective treatment for
type 2 diabetes?
Bariatric procedures aim to reduce weight and maintain weight loss through altering energy balance primarily by reducing food intake and modifying the physiological changes that drive weight regain. There also appear to be independent metabolic benefits, associated with effects of incretins and possibly other hormonal or neural changes after some surgical procedure in addition to weight loss. For example, rapid and sustained improvements in glycaemic control can be achieved within days of gastric bypass surgery, before any significant weight loss is evide A 2009 Cochrane review including patients with and without diabetes concluded that bariatric surgery resulted in greater weight loss than conventional treatment in obese class I (BMI>30) as well as severe obesity, accompanied by improvements in comorbidities such as type 2 diabetes, hypertension and improvements in health-related quality of lif A less rigorous systematic review and meta-analysis of 621 studies which included about 135,000 patients identified 103 studies reporting on the remission of the clinical and/or laboratory manifestations of diabet Overall, 78.1% of patients had "remission" of diabetes following surgery. Among patients with diabetes at baseline, 62% remained in remission more than two years after surgery. There were significant limitations to this review as remission was largely based on clinical reporting, not HbA1c or other biochemical outcomes, and follow up of most cohorts poorly described. The Swedish Obese Subjects study clearly demonstrated the prevention and sustained remission of type 2 diabetes in a group of 2037severely obese patients electing to have bariatric surgery when compared with well-matched controls at 2 and 10 years follow-up (Table 2). Table 2: 2 & 10 year diabetes incidence and remission rates from the
Swedish Obese Subjects S
Remission based on fasting plasma glucose <7.0 mmol/l and not on hypoglycaemic therap
The extent of remission of type 2 diabetes is influenced by the extent of weight loss, weight regain, duration of diabetes, the pre-surgery hypoglycaemic therapy requirements, and the choice of bariatric procedure. In addition each patient‟s commitment to modifying their diet and levels of exercise within a framework of ongoing multidisciplinary care will influence outcomes. Remarkably, there is only a sole acceptably designed prospective randomised control trial (RCT) which has investigated bariatric surgery specifically as a treatment for type 2 diab It compared laparoscopic adjustable gastric banding as part of a comprehensive management program to conventional diabetes therapy with a focus on weight loss by diet and exercise. After two years, remission of diabetes was significantly more common in those who had received surgery (73% vs. 13%). 2.8
Are there other benefits from bariatric surgery for persons with
type 2 diabetes?
Severe obesity is associated with a large number of health problems in addition to type 2 diabetes. A review of more than 1.4 million participants in prospective studies largely from North America, Europe and Australia show a consistent progressive rise in the mortality hazard ratios with increasing BM(Figure 3). A similar analysis by the Prospective Studies Collaboration found the risk of diabetes-related death was quadrupled for morbidly obese individual Table 3: Mortality hazard ratios for white non-smok
Follow-up of participants in the Swedish Obese Subjects Study after an average of 11 years found that bariatric surgery was associated with a 29% reduction in all-cause mortality after accounting for sex, age and risk factors in this severely obese grou Bariatric surgery also led to a specific reduction in cancer incidence in wom Other studies have confirmed this mortality advantage when compared with community matched control A large retrospective cohort study of almost 8000 patients who had undergone gastric bypass surgery were compared for long term mortality with age, sex and BMI matched controls who had applied for driver‟s licences (Utah, USA The analysis reported an adjusted long-term all-cause mortality reduction of 40% in the surgical group. Specific mortality reductions in the operated group were 56% for coronary artery disease, 92% for diabetes, and 60% for cancer when compared with matched controls. It would be expected that morbidly obese patients who have bariatric surgery as a treatment primarily for type 2 diabetes would also experience the benefits of weight loss on other aspects of their health, for example debilitating osteoarthritis or obstructive sleep apnoea. Many studies have demonstrated major improvements in health related quality of life following bariatric surgery using both generic and obesity specific quality of life instrument 2.9
Is bariatric surgery cost-effective for the obese person with type 2
The costs of type 2 diabetes are substantial. In the United States, the lifetime cost has been estimated at US$172,000 for a person diagnosed at the age of 50, and US$305,000 if diagnosed at the age of The estimate included both the direct medical costs of diabetes and its complications, and indirect costs caused by work absence, reduced productivity at work, disability and premature death. Over 60% of the medical cost was incurred within 10 years of diagnosis. Bariatric surgery for severe obesity, regardless of diabetes status, has been assessed as cost-effectivand in some analyses cost saving or A literature review identified three cost-effective analyses of bariatric surgery for patients specifically with diabetes (Table 4). All three studies found bariatric surgery to be either very cost-effective or dominant as a therapy for type 2 diabetes relative to standard therapy. Study analyses have been conservative. The finding of "cost-effectiveness" indicates that health benefits are achieved at an acceptable price relative to country-specific cost-effectiveness thresholds. The "dominant" result indicates that an intervention generates both cost savings and health benefits over the lifetime of the cohort. This is a rare outcome and provides the most compelling evidence for funding based on economic criteria. It is recognized that cost-effectiveness studies have not been conducted in low- and middle-income countries where high-cost interventions for macro- and micro-vascular complications may not be available. On the other hand, life expectancy might indeed be improved by bariatric surgery in these settings and morbidity decreased. It is up to each health system to determine whether bariatric surgery with its support services is economically appropriate when weighed against the provision of essential medicines and other secondary prevention initiatives, such as foot care, education and retinal screening, which can be cost-saving in low-income countries. Cost effectiveness of bariatric procedures in people with
Keating et al
₋ Banding surgery Hoerger et
USA, $US 2005,
₋ Bypass surgery ₋ Banding surgery ₋ Bypass surgery ₋ Banding surgery Picot et al.UK, €
2006, 20 years
Table notes: *Base case; QALY: Quality-adjusted-life-years.
In mid 2006: 1 Euro = AUD1.72/ GBP0.69/ USD1.28
2.10 What eligibility guidelines already exist on bariatric surgery for type
A number of guidelines exist on the use of bariatric surgery for the treatment of severe obesity in general, and for the treatment of type 2 diabetes in particular. They are summarised in Table 5. Most of the existing guidelines reflect the expert recommendations of the NIH Consensus Development Conference Statement March 1991. The current NIH website warns that their information is dated and provided solely for historic purpo Table 5: National and international guidelines for eligibility for bariatric
Eligible (A):BMI >40
1 weight loss control of diabetes and weight loss The guidelines above are qualified by the following common elements Appropriate non-surgical weight loss measures have been tried and failed There is the provision for, and a commitment to, long term follow-up Individual risk to benefit ratio needs to be evaluated A recent Diabetes Surgery Summit of 50 international experts examined gastrointestinal (GI) surgery for the management of type 2 diabetes. Delegates strongly endorsed that conventional GI surgery Roux-en-Y gastric bypass,(RYGB), laparoscopic adjustable gastric band (LAGB), or bilio- pancreatic diversion (BPD) should be considered for the treatment of type 2 diabetes in acceptable surgical candidates with BMI >35 kg/m2 who are inadequately controlled by lifestyle and medical therapy. Further trial evidence was deemed necessary for inadequately controlled type 2 diabetes in candidates suitable for surgery with mild-to-moderate obesity (BMI 30–35 2.10.1 Recommendations for Adolescents
Long-term whole-of-family lifestyle change, with high quality medical management, is the mainstay of paediatric obesity treatment. However, the growing prevalence of severe obesity in children and adolescents demonstrates a need for additional therapy. Bariatric surgery is only considered suitable for adolescents of developmental and physical maturity. There are a range of guidelines and consensus reports that have similar recommendations. A recent position statement was developed by the Australian and New Zealand Colleges for paediatric physicians and surgeons, and the Obesity Surgery Society of Australia and New Zealan The statement recommended surgery be considered if adolescents had BMI >40 kg/m2, or >35 kg/m2 with severe co-morbidities (including type 2 diabetes), were aged 15 years or more, with Tanner pubertal stage 4 or 5 and skeletal maturity, and could provide informed consent. Potential candidates should have failed a multidisciplinary program of lifestyle +/- pharmacotherapy for 6 months, and they and their family must be motivated and understand the need to participate in post-surgical therapy and follow-up. Surgery should be provided in units affiliated with teams experienced in the assessment and long-term follow-up of the metabolic and psychosocial needs of adolescent patients. Very similar eligibility criteria, with some variation in youngest age and BMI, have been listed in European and US publicatio This IDF position statement advises that only 2 procedures, namely Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB), are currently conventional bariatric surgical procedures for adolescents. 2.11 Do bariatric procedures vary in their effectiveness?
A number of bariatric surgical procedures are effective in achieving weight loss. Those that involve more extensive surgery, such as RYGB, generally lead to greater weight loss and more profound metabolic changes, at least initially, than less invasive, non-diversionary procedures such as LAGB. RYGB procedures influence the gut hormonal milieu and provide an early non-weight related improvement in glycaemic control of type 2 diabetes. It is not clear if these changes are durable or have a fundamental effect on the underlying mechanisms driving type 2 diabetes. In the longer term weight loss may be the key benefit. There is absolutely no evidence to support subcutaneous lipectomy (liposuction) as a treatment for type 2 diabetes in obese patient A systematic review of the literaturby Buchwald et al. reported that diabetes remits or improves in the majority of patients after bariatric surgery. The procedures producing greater excess weight loss lead to higher remission rates (Table 6). This review, however, was limited by the quality of the available literature where follow-up varied, there was no consistent definition of remission, and biochemical measures of remission were usually not reported. Table 6: Estimated weight loss and percentage of those with diabetes
who remit at 2 years after conventional bariatric procedures
(Systematic review (Buchwald et al))
% Excess BMI loss* % Remission of Diabetes Bilio-pancreatic Roux-en-Y gastric bypass Laparoscopic adjustable *% Excess BMI loss = mean % on BMI in excess of 25 that is lost
The choice of bariatric procedure is complex requiring a careful risk-benefit analysis and acceptance of variation in regional practice and expertise. The decision must be made by severely obese patients in consultation with their bariatric surgical multidisciplinary team. Factors to consider in patients with type 2 diabetes include: Expertise and experience in the bariatric surgical procedures The patient‟s preference when the range of risks and benefits, the importance of compliance, and the effects on eating choices and behaviours have been fully described. The patient‟s general health and risk factors associated with high peri- operative morbidity and mortality. The simplicity and reversibility of a procedure. The duration of type 2 diabetes and the degree of apparent residual beta-cell function The follow-up regimen for the procedure and the commitment of the patient to adhere to it. It is important to recognise that all conventional surgical procedures vary in their risks and benefits, and to date there are few hard data that can be used to match patients to procedures. Recommendations made by this consensus apply to currently accepted bariatric surgical procedures and do not apply to new experimental procedures The consensus group believe that RYGB, LAGB, BPD and duodenal switch variant (BPD-SD), and sleeve gastrectomy (SG) as currently accepted procedurHowever, it was acknowledged that there was limited medium or long term data regarding SG, and there are safety, nutritional and metabolic concerns with BPD and BPD (DS). Two procedures were considered accepted procedures in adolescents - RYGB and LAGB (see the section on Adolescents 2.12 What are the risks of bariatric surgery?
The 30-day mortality associated with bariatric surgery is estimated at 0.1 – 0.3%, a rate similar to that for laparoscopic cholecystectom and described as „low Programme and patient factors found to be associated with increased risk are shown in Table 7. The presence of type 2 diabetes has not been found to be associated with increased risk for bariatric surgery. Table 7: Patient and program factors associated with risk of surgery.
Program-Surgical Factors "Higher Risk"
Patients Factors "Higher
Surgeon inexperience or in learning curve for the
Low volume centre or surgeon performing surgery
Morbidity and mortality increase with the complexity of
Open compared with laparoscopic procedures
Obstructive sleep apnoea High risk of pulmonary Limited physical mobility The most common complications of bariatric surgery include anastomotic and staple line leaks (3.1%), wound infections (2.3%), pulmonary events (2.2%), and haemorrhage (1.7%). Morbidity rates are lower after laparoscopic procedures, which constitute a steadily increasing proportion of bariatric A new study by the US Agency for Healthcare Research and Quality reported a 21% decline in complications after bariatric surgery between 2002 and 2006 This work compared complications among >9,500 patients who underwent obesity surgery at 652 hospitals in 2001–2002 vs. 2005–2006. Complication rates fell from 24% to 15%, despite increases in the percentage of older and sicker operative patients. Post-surgical infection rates dropped by 58%, while other complications such as abdominal hernias, staple leakage, respiratory failure, and pneumonia diminished by 29–50%. Other complications remained unchanged (ulcers, dumping, haemorrhage, wound re-opening, deep-venous thrombosis and pulmonary embolism, heart attacks, and strokes), and none Early post-operative morbidity and mortality are related to the complexity of the surgery. The US Bariatric Outcomes Longitudinal Database (BOLD) reviewed over 57,000 consecutive procedures and reported one or more complication at 1-year rates of 4.6%, 10.8%, 14.9% and 25.7% following LAGB, sleeve gastrectomy, RYGB and BPD respectivel Thirty day post-surgical mortality follows a similar trend with 0.1% for LAGB, 0.5% for RYGB and 1.1 for BP The US Agency for Healthcare Research and Quality reported a 9-fold increase in bariatric surgery for the period 1998-2004 with a reduction in overall early mortality from 0.89% to 0.19%. Improvements have been attributed to higher hospital volumes, a move to laparoscopic surgery and an increase in banding Longer term surgical complications and need for surgical revisions are not uncommon, and expected problems are usually specific to the surgical Early detection and appropriate management of complications is very important. All those managing post-bariatric surgical patients should have a low threshold for surgical referral should a complication be suspected. Longer-term concerns, especially with RYGB and BPD, include vitamin and mineral deficiencies, osteoporosis and, rarely, Wernicke‟s encephalopathy and severe hypoglycaemia from insulin hypersecreti Clinical guidelines developed by the American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery address these important issue A summary of nutritional risk with each procedure is shown in Table 8. This does not reflect all nutritional risks and a review of studies for the diversional procedures RYGB and BPD+/-DS. Long-term dietary advice, evaluation and supplementation is required for all procedures. Table 8: A summary of more common nutritional concerns for each procedure
Fat Soluble Vitamins
and Essential Fatty
Recommended daily intake (allowance) or standard multivitamin preparation likely to
Significant risk of deficiency or increased requirements. Specific supplementation is
appropriate especially in higher risk groups.
High risk of deficiency. Additional specific supplementation is necessary to prevent
deficiency. Careful monitoring is recommended. Supplementation well in excess of
daily requirements may be necessary.
Abbreviations also given in legend
The risks of each procedure need to be considered in the light of potential reductions in mortality, morbidity or comorbidity, quality of life and productivity. Realistic expectations are important and risk-benefit ratio assessed individually for each patient, accounting for both peri-operative risk and possible long-term Continuing efforts are required to monitor the safety, efficacy and long term effects of bariatric surgery. There is a range of national bariatric surgery registries and continuing long-term longitudinal studies. We encourage the expansion of national registries and acknowledge that these must be well resourced to function appropriately. Severe obesity and type 2 diabetes are chronic conditions needing a chronic disease approach to care. 2.13 What are the components of successful bariatric surgery?
There is a range of comprehensive guidelines for the use of bariatric procedures for obesity including the UK National Institute for Health and Clinical Excellence (2006 the combined American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery guidelines (2008)and European clinical guidelines (200 Considerations with respect to type 2 diabetes and components of successful programs include: It is important to acknowledge that bariatric surgery is a component of the ongoing process of chronic disease management of type 2 diabetes and Bariatric surgery should be performed in high volume centres with multi- disciplinary teams that understand and are experienced in the management of obesity and diabetes. Members of the team should have understanding across disciplines, and work together with common expectations and goals. The team needs to integrate with primary care, diabetes management, nutritional and lifestyle support, and surgeon‟s teams with consistent messages and agreed policies. The surgical team must have undertaken relevant supervised training, and have specialist experience in types of bariatric surgery performed within the Pre-surgical assessment needs to be comprehensive involving MDTs and include assessment of metabolic, physical, psychological and nutritional health. Patients should have realistic expectations of the risks and benefits of surgery along with their lifelong role in lifestyle intervention, nutritional support and follow-up. Management of diabetes and other comorbidities should be optimised and short-term pre-operative weight loss considered to improve health and visibility at the time of surgery. The multidisciplinary team need to understand and recognise early and long term complications in a timely manner, and know when to refer back to the surgeon, or others for specific care. Life-long follow-up on at least an annual basis is needed for ongoing lifestyle support, and post-surgical and diabetes monitoring. Teams should collect prospective data and measure diabetes outcomes in methods consistent with IDF recommendations. Regular, postoperative nutritional monitoring is required, with attention to appropriate diet after the procedure, monitoring of micronutrient status, and individualised nutritional supplementation, support and guidance to achieve long-term weight loss and weight maintenance. Follow-up should include a psychological evaluation, support and therapy if appropriate. Mental illness, especially depression, is common in diabetes and severe obesity. In order to help sustain ongoing weight loss from bariatric surgery, patients must be committed to increased levels of ongoing daily physical activity. All practices are encouraged to engage and promote national programmes of "centres of excellence" of equivalent and collect prospective data through registries. 2.14 Which patients with type 2 diabetes should be considered for
There is clear evidence that bariatric surgery is a very effective therapy for obese patients with type 2 diabetes. The place of surgery in diabetes treatment algorithms needs to be established (see below). Currently surgery is considered optional and as such in the countries with the highest bariatric surgery uptake less than 2% of eligible patients are treated annually. Indications for bariatric surgery typically classify those who are eligible for surgery, but a recommendation of surgical referral as best practice or prioritisation has not been widely considered. Diabetes management algorithms should now include points at which bariatric surgery should be considered and points at which referral is recommended or prioritised (Table 9). In patients with type 2 diabetes eligibility or prioritisation for surgery should consider BMI, ethnicity, associated weight related comorbidity, weight trajectory and the response of diabetes and comorbidity to optimal medical therapy. Conditional eligibility or prioritisation should be assessed by a team specialising in diabetes. Surgical referral implies a thorough bariatric surgical MDT assessment of risk and benefit. Table 9: Eligibility and prioritisation for bariatric surgery based on failed non-
surgical weight loss therapy*, BMI, ethnicity** and disease control
Eligible for surgery
Prioritised for Surgery
YES-Conditional*** YES-Conditional*** In all cases patients should have failed to lose weight and sustain significant weight
loss through non-surgical weight management programmes, and have type -2 diabetes
that has not responded adequately to lifestyle measures (+/- metformin) with a HbA1c
Action points should be lowered by 2.5 BMI point levels for Asian
*** HbA1c > 7.5 despite fully optimised conventional therapy, especially if weight is
increasing, or other weight responsive co-morbidities not achieving targets on
conventional therapies. For example blood pressure, dyslipidaemia and obstructive
Contraindications for bariatric surgery include; current drug or alcohol abuse, uncontrolled psychiatric illness, and lack of comprehension of the risks - benefits, expected outcomes, alternatives and lifestyle changes required with bariatric surg In addition there are general conditions that would contraindicate elective surgery, and specific conditions that substantially increase the risk of surgery, later complications or poor outcomes. These should be assessed by the surgical team. 2.15 Should bariatric surgery be integrated into diabetes treatment
Existing international treatment guidelines for type 2 diabetes provide little information or direction on the role of bariatric interventions in treatment. By contrast, the American Diabetes Association recommends that bariatric surgery be considered as a treatment option for type 2 diabetes when the patient‟s BMI exceeds Algorithms developed for treating type 2 diabetes should include recommendations as to where bariatric surgery is an option and the circumstances where it should be prioritised. Almost all severely obese patients are unsuccessful in their efforts to achieve sustained and significant weight loss and there is evidence that weight loss induced by bariatric surgery can lead to remission of hyperglycaemia in the majority of patients with diab Earlier intervention increases the likelihood of remissi In the remaining patients, residual hyperglycaemia is easier to manage following bariatric surgery. It can, therefore, be argued that bariatric surgery for the severely obese with type 2 diabetes should be considered early as an option for eligible patients, rather than being held back as a last resort. 2.16 Is there equitable access to bariatric surgery?
Obesity is more common in socioeconomically disadvantaged people in the developed world but the vast majority of bariatric surgery procedures in the developed world are performed in the private sector. Current access to surgical treatment for people with severe obesity and type 2 diabetes is not equitable and discriminates against individuals who are most likely to benefit. There are particular problems in those emerging countries where rates of severe obesity are increasing rapidly and health care resources are extremely limited. There will be resource implications in the short-term from increasing access to bariatric surgery, but it is essential to consider not just the financial costs of the procedures and necessary follow-up, but also the potential savings from achieving improved control of type-2 diabetes, its related metabolic and other complications and comorbidities. 2.17 What is a successful outcome of bariatric surgery for a person with
type 2 diabetes?
There needs to be an agreed definition of success and on the basis of present data, the achievable goal of bariatric surgery is not cure, but remission, of the diabetes state. Improved patient health would be recognised by individualised optimisation of metabolic state which involves normalisation of metabolic state, no hypoglycaemia total cholesterol < 4 mmol/l; LDL cholesterol < 2 mmol/l triglycerides < 2.2 mmol/l BP < 135/85 mmHg >15% weight loss With reduced medication from the pre-operated state or without other medications (where medications are continued, reduced doses from pre- surgery with minimal side effects would be expected) A substantial improvement in metabolic state may be defined as: Lowering of HbA1c by > 20% LDL < 2.3 mmol/l BP < 135/85 mmHg With reduced medication from the pre-operated state The above definitions, with a focus on diabetes, complement broader success measures including substantial sustained weight loss, improved quality of life and improvement or remission of obesity associated comorbidity. 2.18 Novel extra-luminal and endo-luminal procedures and devices and
novel bariatric metabolic devices
2.18.1 Novel extra-luminal and endo-luminal procedures and devices
Several novel procedures have developed from elegant experiments using rodent models used to examine the mechanism of action of bariatric surgery. The aim has been to enhance the non-weight loss glycaemic control benefits of the GI interventions. These procedures may evolve as therapy for type 2 diabetes in those without a significant weight issues. These novel procedures include duodenal-jejunal bypa(DJB) and ileal interpositi(IT). First described by Rubino, DJB is a stomach-sparing bypass of a short portion of proximal intestine, comparable to the segment excluded in a standard RYGB. A number of early human clinical trials have been performed and improvements in glycaemic control have been reported, but these may be less impressive in subjects with a lower BM Ileal interposition (IT) involves the surgical transposition of a small segment of ileum into the proximal intestine. Generally, short term studies in humans have reported improved glycaemi These procedures remain experimental and are likely to require technical refinements before larger scale longer-term safety and efficacy 2.18.2 Novel bariatric metabolic devices
Multiple, mostly novel, devices and techniques are being explored to utilise the GI tract‟s putative mechanism for altering energy balance and for non-weight loss effects on glucose tolerance. In general the techniques can be divided by mode of placement into those that are upper GI endoscopic or laparoscopic, with some combining approaches. Endoscopically placed upper GI devices include the simple positioning of a device in the upper GI tract. Examples include intra-gastric balloons which are currently available for temporary placement (usually 6 months, but repeat treatment for extending the duration of treatment beyond 2 years have been reported) and which provide 10-15% weight loss during the period of placement, plus a range of novel devices under development which are placed in the stomach to mimic restriction, or placed in the trans-pyloric area to delay or regulate gastric emptying. Some endoscopically placed devices are physically fixed to the upper GI tract to mimic proximal gastric restriction of the LAGB, while some use endoluminal impervious sleeves to bypass the gastro-duodenal upper jejunal area to mimic the RYGB, or bypass the duodenum and proximal jejunum to mimic the DJB. A range of laparoscopic procedures to place novel electronic gastric or gastro-duodenal motility stimulators, and vagal nerve blocking devices are also under investigation. Results in humans to date have been mixed with some devices providing inadequate weight loss and others promising results. These are considered less invasive than most conventional bariatric surgical procedures. Whilst there is excitement in the novel medical device area the efficacy, safety, durability and clinical utility of many of these procedures in the management of obese people with type 2 diabetes is still to be 3.
Management of Diabetes
3.1.1 Bariatric surgery is an appropriate treatment for people with type 2 diabetes and obesity (BMI equal to or greater than 35) not achieving recommended treatment targets with medical therapies, especially where there are other obesity related co-morbidities. Under some circumstances people with a BMI 30-35 should be eligible for surgery 3.1.2 It is up to each health system to determine whether bariatric surgery with its support services is economically appropriate. 3.1.3 Surgery should be considered as complementary to medical therapies to reduce micro-vascular and cardiovascular risk 3.1.4 Patients should be assessed and managed by experienced multi- disciplinary teams 3.1.5 Glycaemic control should be optimised peri-operatively and should be closely monitored after surgery 3.1.6 On-going and long-term nutritional supplementation and support must be provided to patients after surgery 3.1.7 Apart from conventional procedures now in use new techniques and devices should be explored in research settings only. Conventional procedures should be standardised. Other techniques, variations and novel devices can be introduced when supported by an evidence base. 3.1.8 Procedure selection requires appropriate assessment of risk vs. benefit of each operation as part of the process for selecting the surgical treatment options for an individual patient. 3.1.9 New bariatric procedures require robust assessment for their efficacy, safety, and durability using similar principles to those for assessing new drug therapies and having regards to the benefits and risks of established therapy. 3.1.10 Regional surgical expertise, multidisciplinary team experience, and documented quality outcomes are important factors in the regional choice of bariatric procedures. 3.1.11 There should be a minimal accepted data set for pre-surgery and follow- up to allow audit of clinical programmes eg. Fasting glucose and insulin Waist circumference Retinopathy status (recent eye exam) Nephropathy (eg test for microalbuminuria within previous year) Liver functions tests Lipid profile Blood pressure measurement Foot exam (recent) Documentation of medications – (glycaemia, lipids & HT) These should be used preoperatively. Fasting C peptide where available Auto- antibody status eg anti-GAD where available 3.1.12 All longitudinal studies should include quality of life as one of the 3.1.13 It should be recognised that a prolonged period of normalisation of glycaemic control has benefit even if there is eventual relapse. 3.2
3.2.1 Studies are needed to establish more robust criteria than BMI for predicting benefit from surgery and define which patients benefit most from which procedures. 3.2.2 Studies are needed to establish the benefit of surgery for persons with diabetes and BMI < 35. 3.2.3 Studies are needed to establish whether bariatric procedures prevent or slow the progressive loss of beta-cell function characteristic of type 2 3.2.4 Studies are required to document the course of complications after surgery obtain evidence that surgery stabilises and ideally improves microvascular complications. 3.2.5 Studies are needed to establish the duration of the benefit of surgery. 3.2.6 Studies are needed to establish the mechanisms of the success of surgery and the mechanisms associated with recurrence. 3.2.7 Studies are needed to establish the long term complications of surgery. 3.2.8 New techniques should be assessed rigorously for efficacy and safety and ideally mechanisms, and demonstrate their equivalence or superiority to classical surgical techniques, moving to human studies after appropriate pre-clinical studies. 3.2.9 Studies are needed to define the best regimens of diabetes management post bariatric surgery. 3.2.10 It will be important to phenotype candidates for surgery to define what will be the most appropriate bariatric procedure for persons with diabetes in different age groups, different duration of diabetes etc. 3.2.11 Randomised controlled trials are needed to evaluate and compare different bariatric procedures for the treatment of diabetes between themselves as well as emerging non-surgical therapies. IDF Consensus Panel
Professor George Alberti* Imperial College, London and Newcastle University, UK Professor John B. Dixon* Baker IDI Heart & Diabetes Institute, Melbourne, Australia Professor Francesco Rubino* Weill Cornell Medical College, USA Professor Paul Zimmet* Baker IDI Heart & Diabetes Institute, Melbourne, Australia Professor Stephanie Amiel King's College, London, UK Professor Louise A. Baur University of Sydney, Australia Professor Nam H. Cho Deparment of Preventive Medicine, Ajou University School of Medicine, Korea. Dr. Bruno Geloneze University of Campinas (UNICAMP), Brazil Professor Jan Willem Greve Atrium Medical Center, Parkstad Heerlen, Netherlands firstname.lastname@example.org, Professor Linong Ji Peking Unviersity People's Hospital, China Dr. Muffazal Lakdawala Saifee Hospital, Mumbai, India Professor Wei-Jei Lee Ming-Sheng General Hospital, National Taiwan University, Taipei, Taiwan Professor Pierre Lefebvre International Diabetes Federation and Department of Medicine, University of Dr. Carel le Roux Imperial College London, UK Professor Jean-Claude Mbanya International Diabetes Federation, Younde, Cameroon Professor Gertrude Mingrone Catholic University of Rome, Italy Professor Philip R. Schauer Cleveland Clinic Lerner College of Medicine, USA Professor Luc Van Gaal Antwerp University Hospital, Belgium email@example.com, Dr. David Whiting International Diabetes Federation, Brussels, Belgium Professor Bruce M. Wolfe Oregon Health and Science University (OHSU), USA We acknowledge the contributions of Catherine Keating for reviewing the cost- effectiveness of bariatric surgery, and Gary Wittert and Joe Proietto for their constructive review of this Position Statement. We also acknowledge the assistance and direction provided by a group of Australian endocrinologists chaired by Professor The consensus meeting was supported with an unrestricted educational grant by: Allergan Inc, Irvine, CA, USA Ethicon, Ethicon Endo-Surgery, Inc, Cincinnati, Ohio, USA MetaCure Inc, Mount Laurel, NJ, USA These companies played no role in the discussion or preparation of this position paper. REFERENCES
Unwin N, Gan D, Whiting D. The IDF Diabetes Atlas: providing evidence, raising awareness and promoting action. Diabetes Res Clin Pract;87:2-3. 2. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract;87:4-14. 3. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006;444:875-80. 4. Kumanyika SK, Obarzanek E, Stettler N, et al. Population-based prevention of obesity: the need for comprehensive promotion of healthful eating, physical activity, and energy balance: a scientific statement from American Heart Association Council on Epidemiology and Prevention, Interdisciplinary Committee for Prevention (formerly the expert panel on population and prevention science). Circulation 2008;118:428-64. 5. Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007;357:741-52. 6. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009;122:248-56 e5. 7. Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004;351:2683-93. 8. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. Jama 2004;292:1724-37. 9. Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007;357:753-61. 10. Fried M, Hainer V, Basdevant A, et al. Inter-disciplinary European guidelines on surgery of severe obesity. Int J Obes (Lond) 2007;31:569-77. 11. Mechanick JI, Kushner RF, Sugerman HJ, et al. American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery Medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient. Endocr Pract 2008;14 Suppl 1:1-83. 12. NICE. Obesity: guidance on the prevention, identification, assessment and management of overweight and obesity in adults and children. In. London: National Institute for Health and Clinical Excellence; 2006. 13. Lakdawala M, Bhasker A. Report: Asian Consensus Meeting on Metabolic Surgery. Recommendations for the use of Bariatric and Gastrointestinal Metabolic Surgery for Treatment of Obesity and Type II Diabetes Mellitus in the Asian Population: August 9th and 10th, 2008, Trivandrum, India. Obes Surg 2010;20:929-36. 14. Rubino F, Kaplan LM, Schauer PR, Cummings DE. The Diabetes Surgery Summit consensus conference: recommendations for the evaluation and use of gastrointestinal surgery to treat type 2 diabetes mellitus. Ann Surg 2010;251:399-405. 15. Standards of medical care in diabetes--2010. Diabetes Care;33 Suppl 1:S11-61. Zimmet P, Campbell L, Toomath R, Twigg S, Wittert G, Proietto J. Bariatric surgery to treat severely obese patientswith type 2 diabetes: A consensus statement (in press). Obesity Reseach and Clinical Practice 2011. 17. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004;363:157-63. 18. WHO. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000;894:1-253. Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 2009;52:17-30. 20. Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 1995;122:481-6. 21. Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 1994;17:961-9. 22. Gregg EW, Cheng YJ, Narayan KM, Thompson TJ, Williamson DF. The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 1976-2004. Prev Med 2007;45:348-52. 23. Pi-Sunyer X, Blackburn G, Brancati FL, et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 2007;30:1374-83. 24. Norris SL, Zhang X, Avenell A, et al. Long-term non-pharmacologic weight loss interventions for adults with type 2 diabetes. Cochrane Database Syst Rev 2005:CD004095. 25. Norris SL, Zhang X, Avenell A, Gregg E, Schmid CH, Lau J. Pharmacotherapy for weight loss in adults with type 2 diabetes mellitus. Cochrane Database Syst Rev 2005:CD004096. 26. Farooqi IS, O'Rahilly S. Genetic factors in human obesity. Obes Rev 2007;8 Suppl 1:37-40. 27. Swinburn B, Egger G. Prevention of type 2 diabetes. Prevention needs to reduce obesogenic environments. BMJ 2001;323:997. 28. Schwartz MW, Porte D, Jr. Diabetes, obesity, and the brain. Science (New York, NY 2005;307:375-9. 29. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995;332:621-8. 30. Foo J, Toomath R, Wickremesekera SK, Bann S, Stubbs R. Bariatric surgery: a dilemma for the health system? The New Zealand medical journal 2010;123:12-4. 31. Dixon JB. Referral for a Bariatric Surgical Consultation: It is Time to Set a Standard of Care. Obes Surg 2009;19:641-4. 32. Tripathy D, Chavez AO. Defects in insulin secretion and action in the pathogenesis of type 2 diabetes mellitus. Curr Diab Rep 2010;10:184-91. 33. UKPDS16. U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group. Diabetes 1995;44:1249-58. 34. Riddle MC, Ambrosius WT, Brillon DJ, et al. Epidemiologic relationships between A1C and all-cause mortality during a median 3.4-year follow-up of glycemic treatment in the ACCORD trial. Diabetes Care 2010;33:983-90. 35. Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008;359:1577-89. 36. Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203. 37. Scheen AJ, Paquot N, Lefebvre PJ. [United Kingdom Prospective Diabetes Study (UKPDS): 10 years later]. Revue medicale de Liege 2008;63:624-9. Liebl A, Mata M, Eschwege E. Evaluation of risk factors for development of complications in Type II diabetes in Europe. Diabetologia 2002;45:S23-8. 39. Roman G, Hancu N. Early insulin treatment to prevent cardiovascular disease in prediabetes and overt diabetes. Horm Metab Res 2009;41:116-22. 40. Bailey CJ, Del Prato S, Eddy D, Zinman B. Earlier intervention in type 2 diabetes: the case for achieving early and sustained glycaemic control. Int J Clin Pract 2005;59:1309-16. 41. Colquitt JL, Picot J, Loveman E, Clegg AJ. Surgery for obesity. Cochrane Database Syst Rev 2009:CD003641. 42. Pories WJ, Albrecht RJ. Etiology of type II diabetes mellitus: role of the foregut. World J Surg 2001;25:527-31. 43. Rubino F, R'Bibo S L, del Genio F, Mazumdar M, McGraw TE. Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus. Nat Rev Endocrinol 2010;6:102-9. 44. Laferrere B, Teixeira J, McGinty J, et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab 2008;93:2479-85. 45. Klein S, Ghosh A, Cremieux PY, Eapen S, McGavock TJ. Economic Impact of the Clinical Benefits of Bariatric Surgery in Diabetes Patients With BMI >/=35 kg/m(2). Obesity 2010. 46. Dixon JB, O'Brien PE, Playfair J, et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. Jama 2008;299:316-23. 47. Berrington de Gonzalez A, Hartge P, Cerhan JR, et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med;363:2211-9. 48. Whitlock G, Lewington S, Sherliker P, et al. Body-mass index and cause- specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009;373:1083-96. 49. Sjostrom L, Gummesson A, Sjostrom CD, et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol 2009;10:653-62. 50. Peeters A, O'Brien P E, Laurie C, et al. Substantial Intentional Weight Loss and Mortality in the Severely Obese. Ann Surg 2007;246:1028-33. 51. Kolotkin RL, Crosby RD, Gress RE, Hunt SC, Adams TD. Two-year changes in health-related quality of life in gastric bypass patients compared with severely obese controls. Surg Obes Relat Dis 2009;5:250-6. 52. Dixon JB, Dixon ME, O'Brien PE. Quality of life after lap-band placement: influence of time, weight loss, and comorbidities. Obes Res 2001;9:713-21. 53. Zhuo X, Zhang P, Hoerger T. Lifetime cost of type 2 diabetes in the U.S. Presented at American Diabetes Association meeting, 2010. Abstract 0434-PP. 2010. 54. Picot J, Jones J, Colquitt JL, et al. The clinical effectiveness and cost- effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation. Health Technol Assess 2009;13:1-190, 215-357, iii-iv. 55. Cremieux PY, Buchwald H, Shikora SA, Ghosh A, Yang HE, Buessing M. A study on the economic impact of bariatric surgery. The American journal of managed care 2008;14:589-96. 56. Keating CL, Dixon JB, Moodie ML, et al. Cost-effectiveness of surgically induced weight loss for the management of type 2 diabetes: modeled lifetime analysis. Diabetes Care 2009;32:567-74. Hoerger TJ, Zhang P, Segel JE, Kahn HS, Barker LE, Couper S. Cost- effectiveness of bariatric surgery for severely obese adults with diabetes. Diabetes Care;33:1933-9. 58. (Accessed 18 December 2010, 2010, at 59. NIH. Gastrointestinal surgery for severe obesity: National Institutes of Health Consensus Development Conference Statement. Am J Clin Nutr 1992;55:615S-9S. 60. NHMRC. Clinical Practice Guidelines for the Management of Overweight and Obesity in Adults. Canberra: National Health and Medical Research council; 2003. 61. Logue J, Thompson L, Romanes F, Wilson DC, Thompson J, Sattar N. Management of obesity: summary of SIGN guideline. Bmj 2010;340:c154. 62. Baur LA, Fitzgerald DA. Recommendations for bariatric surgeryin adolescents in Australia and New Zealand. J Paediatr Child Health 2010;46:704-7. 63. Inge TH, Krebs NF, Garcia VF, et al. Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics 2004;114:217-23. 64. Klein S, Fontana L, Young VL, et al. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med 2004;350:2549-57. 65. Buchwald H, Oien DM. Metabolic/bariatric surgery Worldwide 2008. Obes Surg 2009;19:1605-11. 66. Buchwald H, Estok R, Fahrbach K, Banel D, Sledge I. Trends in mortality in bariatric surgery: a systematic review and meta-analysis. Surgery 2007;142:621-32; discussion 32-5. 67. DeMaria EJ, Portenier D, Wolfe L. Obesity surgery mortality risk score: proposal for a clinically useful score to predict mortality risk in patients undergoing gastric bypass. Surg Obes Relat Dis 2007;3:134-40. 68. Flum DR, Belle SH, King WC, et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med 2009;361:445-54. 69. Nguyen NT, Hinojosa M, Fayad C, Varela E, Wilson SE. Use and outcomes of laparoscopic versus open gastric bypass at academic medical centers. J Am Coll Surg 2007;205:248-55. 70. Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. Inter-relationships among childhood BMI, childhood height, and adult obesity: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2004;28:10-6. 71. DeMaria EJ, Pate V, Warthen M, Winegar DA. Baseline data from American Society for Metabolic and Bariatric Surgery-designated Bariatric Surgery Centers of Excellence using the Bariatric Outcomes Longitudinal Database. Surg Obes Relat Dis 2010;6:347-55. 72. Encinosa WE, Bernard DM, Du D, Steiner CA. Recent improvements in bariatric surgery outcomes. Medical care 2009;47:531-5. 73. Vetter ML, Cardillo S, Rickels MR, Iqbal N. Narrative review: effect of bariatric surgery on type 2 diabetes mellitus. Ann Intern Med 2009;150:94-103. 74. Dixon JB, O'Brien P. Health Outcomes of Severely Obese Type 2 Diabetic Subjects 1 Year After Laparoscopic Adjustable Gastric Banding. Diabetes Care 2002;25:358-63. 75. Schauer PR, Burguera B, Ikramuddin S, et al. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg 2003;238:467-84; discussion 84-5. 76. Rubino F, Marescaux J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg 2004;239:1-11. Strader AD, Vahl TP, Jandacek RJ, Woods SC, D'Alessio DA, Seeley RJ. Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab 2005;288:E447-53. 78. Geloneze B, Geloneze SR, Fiori C, et al. Surgery for nonobese type 2 diabetic patients: an interventional study with duodenal-jejunal exclusion. Obesity surgery 2009;19:1077-83. 79. Lee HC, Kim MK, Kwon HS, Kim E, Song KH. Early changes in incretin secretion after laparoscopic duodenal-jejunal bypass surgery in type 2 diabetic patients. Obesity surgery 2010;20:1530-5. 80. DePaula AL, Stival A, Halpern A, Vencio S. Thirty-day morbidity and mortality of the laparoscopic ileal interposition associated with sleeve gastrectomy for the treatment of type 2 diabetic patients with BMI <35: an analysis of 454 consecutive patients. World J Surg 2011;35:102-8. 81. Kumar KV, Ugale S, Gupta N, et al. Ileal interposition with sleeve gastrectomy for control of type 2 diabetes. Diabetes technology & therapeutics 2009;11:785-9.
LA ASAMBLEA NACIONAL DE LA REPÚBLICA BOLIVARIANA DE VENEZUELA LEY ORGÁNICA CONTRA LA DISCRIMINACIÓN RACIAL DISPOSICIONES FUNDAMENTALES Capítulo I Disposiciones fundamentales Artículo 1. La presente Ley tiene por objeto establecer los mecanismos adecuados para prevenir, atender, erradicar y sancionar la discriminación racial en cualquiera de sus manifestaciones, garantizando a toda persona y grupos de personas, el goce y ejercicio de sus derechos y deberes consagrados en la Constitución, leyes, tratados, pactos y convenios internacionales relativos a derechos humanos, suscritos y ratificados por la República.