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Misoprostol in gynäkologie und geburtshilfe

FIAPAC Statement
on the use of
Misoprostol in Women's Health Care
www.fiapac.org. October 2011 The prostaglandin E1 analogue is approved for the prevention and treatment of gastro-duodenal ulcers for patients being treated with non-steroidal anti-inflammatory drugs (NSAIDs) - see Table I. It has been on the market since 1985 and is approved in more than 90 countries under the brand name of Cytotec®. Misoprostol has several advantages over other prostaglandins on the market. Being an E1 analogue, it has no effect on the bronchii and the blood vessels. It can be stored at room temperature for a long time provided the aluminium blister is not opened. The 200 microgram tablets are approved for oral use, but there are numerous publications showing the effectiveness of other routes of administration such as vaginal, sublingual, buccal and rectal. The only relevant side effects in clinical practice are gastrointestinal (diarrhoea, nausea, vomiting, oral numbness), skin rash and fever, which are dose and route dependent and self-limiting. Misoprostol in women's health care Table I: Fact sheet on Misoprostol
Producer/patent holder Pfizer, US (formerly Searle) Prostaglandin E1 analogue Tablets, oral, 200 microgram (100 and 50 (vaginal) microgram tablets are available in some countries) Approved indication Prevention and treatment of gastro-duodenal ulcers for patients being treated with NSAIDs Pharmacokinetics after Absorption: rapid oral administration Tmax: 12 ± 3 minutes Terminal half-life: 20-40 minutes. First uterine contractions after 15-20 min Elimination: 80% via urine Today, there is an abundant amount of literature on the safe and effective use of misoprostol for different indications and the number of publications and amount of evidence continues to increase (see Based on the available evidence, even the British Medical Association and Royal Pharmaceutical Society recommend in the British National Formulary the use of misoprostol for unlicensed indications (Table II); a truly rare event. All evidence based guidelines recommend the use of misoprostol in various routes of administration: oral, vaginal, sublingual or buccal (5,6,10). (Table III and IV) Misoprostol is present in the WHO essential medicines list for induction of labour, medical abortion together with mifepristone where abortion is legal, and for incomplete abortion. Furthermore it is approved in some countries for post-partum haemorrhage. Misoprostol in women's health care Table II
Citation from the British National Formulary
No. 61, March 2011
Pages 486, 488 and 489
Induction of abortion:
Misoprostol is given by mouth or by vaginal administration to induce medical abortion
(unlicensed indication).
Induction and augmentation of labour:
Misoprostol is given orally or vaginally for the induction of labour (unlicensed
Table III: Citation from the British RCOG evidence based guideline (5)
Table IV: Citation from the recent French evidence based guidelines Les études évaluant l'efficacité du misoprostol, après 200 mg de mifépristone, selon sa voie d'administration sont en faveur d'une efficacité de la voie sublinguale (hors AMM) et buccale (hors AMM) comparable à celle de la voie vaginale (hors AMM), et supérieure celle de la voie orale (hors AMM au-delà de 7 SA) jusqu'à 9 SA. Recommandations de bonne pratique - Interruption volontaire de grossesse par méthode médicamenteuse, 2010, Haute Autorité de santé, Paris The recommendations on dose and route of administration when used for medical abortion in the first and second trimester and for cervical priming prior to surgical abortion is given in the WHO safe abortion guidance as well as in the Royal College clinical practice guidelines, both of which are currently being updated. Furthermore FIGO has issued guidelines on the use of misoprostol in Obstetrics and Gynaecology which are available a(Table V) (9) In general the vaginal or sublingual application is more effective that the oral route and associated with lower incidence of side effects. Misoprostol in women's health care
Table V: Indications and regimens for use of misoprostol in obstetrics and
gynaecology. All dosages based on 200 microgram tablets. (9)

Induction of labour for Very effective. Now first line in many live baby (>28 weeks) European and US centres. Beware of hyperstimulation. Should not be used if previous Caesarean section. Induction of labour for Good. First line treatment in many intrauterine fetal death centres in Europe and US. Usually used following mifepristone, but works without. 2 tabs sublingual/ More effective than oxytocin. Best used following mifepristone priming. 2 tabs sublingual/ oral/pv 4 hrly or 4 tabs pv 24 hrly Incomplete abortion Good – now a standard option in Europe. >95% effective. Postpartum haemorrhage Prophylactic not as effective as injectable oxytocics, but useful as treatment option. - 2 tabs sublingual Cervical ripening prior to 2 tabs oral/ pv stat Reduces perforation and failure rates. uterine instrumentation 2hours before procedure
Off-label use of medicines
A drug licence alone is not the appropriate determinant of whether a drug is effective for
any given indication. The system of drug licensing was set up to regulate the
pharmaceutical industry and not the medical profession, and its advice should always be
seen in this context. Furthermore, the current licensing system is inadequate in a
situation where the patent holder decides not to apply for an indication as is the case for
misoprostol. (7)
Misoprostol in women's health care Conclusions
Misoprostol has huge potential in obstetric and gynaecological practice and the low rate
of side effects. Unfortunately its crucial beneficial role in women's health care are
currently not sufficiently acknowledged. The lack of approved indications for misoprostol
in Obstetrics & Gynaecology in Europe should not deter health professionals from using
it for indications where there is sufficient evidence for its safe and effective use.
A dedicated misoprostol product approved for several reproductive health indications is
available in France under the name of Gymiso®.
1. Misoprostol for Women's Health: A Review, Blanchard et al., Obstetrics & Gynecology, February 2002, Vol 99, No 2: 316-32 2. Managing Complications in Pregnancy and Childbirth, World Health Organization, 2000, WHO/RHR/00.7; IMPAC, P25 3. Hill K et al. Estimates of maternal mortality for 1995, Bulletin of the World Health Organization, 2001, 79:182-93 4. Demographic and Health Survey Uganda 2000-2001, Uganda National Bureau Of Statistics, Entebbe, Uganda, December 2001 5. Royal College of Obstetricians and Gynaecologists (RCOG). The care of women requesting induced abortion. Evidence-based clinical guideline no. 7. 2004 [London]. 6 WHO safe abortion guidance, Geneva 2003 7 Weeks AD, Fiala C, Safar P. Misoprostol and the debate over offlabel drug use. BJOG 2000;112:269-72. 8 Fiala C, Gemzell-Danielsson K, Review of medical abortion using mifepristone in combination with a prostaglandin analogue, Contraception 2006 (74):66-86 9 Misoprostol for reproductive health, IJGO, 2007, Vol 99 (supplement 2), a special issue with articles covering different aspects published by authors from an expert group 10 Recommandations de bonne pratique - Interruption volontaire de grossesse par méthode médicamenteuse, 2010, Haute Autorité de santé, Paris

Source: http://fiapac.org/static/media/uploads/misoprostol_statement_oct2011.pdf


October 2015 EurEau's Contribution to the European Commission's Strategic Approach on Veterinary Pharmaceuticals in the Environment Globally, pharmaceutical products are regularly administered to both livestock and domestic animals. This is essential for animal welfare and the economy, but doing so ultimately means that pharmaceuticals end up in the aquatic environment. Animals reared commercially are the highest consumers of these products and therefore veterinary medicines are largely a rural, rather than an urban, issue. EurEau believes that good agricultural and animal husbandry practices should be promoted and incentivised. Doing so will reduce the overall amount of pharmaceuticals in the environment and protect water resources, including those used for the abstraction of drinking water. As the main route for veterinary pharmaceuticals to the aquatic environment is diffuse, addressing their use at the source is the most effective solution.

Pii: s0029-7844(00)00794-8

Elective Induction of Labor as a Risk Factor forCesarean Delivery Among Low-Risk Womenat Term ARTHUR S. MASLOW, DO, MSc, AND AMY L. SWEENY, MPH Objective: To determine the effects of elective induction on tions, indicated and elective inductions, and induction the risk of cesarean delivery in a cohort of women with techniques. There is continued criticism of the adequacy