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Medical Information Network Distribution Service Eickholz P, Dannerritz B, Kim TS. Antibiotics in periodontal therapy. Perio. 2005 Dahlen G. Microbiology and treatment of dental abscesses and periodontal endodontic lesions. Periodontol 2000. 2002 Umeda M, Tominaga Y, Yano K, Watanabe H, Ishikawa I. Microbial flora in the acute phase of periodontitis and the effect of local admini- stration of minocycline. J Periodontol. 1996 Greenstein G, Tonetti M. Position paper. The role of controlled drug delivery for periodontitis. J Periodontol. 2000 Hanes PJ, et al. Local anti infective therapy pharmacological agents. A systematic review. Ann Periodontol. 2003 Greenstein G. Review Local drug delivery in the treatment of periodontal disease Assessing the clinical significance of the results. J Periotdontol. 2006 Preus HF, Lassen J, Aass AM, Ciancio SG. Bacterial resistance following subgingival and systemic administration of minocycline. J Clin Periodontol. 1995 Wennstrom JI, et al. 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Differetial clinical treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetencomitans and or Porphyromonas gingivalis. J Clin Periodontol. 1998 Winkel EG, Van Winkelhoff AJ, Timmerman MF, Van der Velden U, Van der Weijden GA. Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double blind placebo controlled study. J Clin Periodontol. 2001 Puvncker P, et al. Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis. J Periodontol. 2001 Mombelli A, et al. Clinical response to local delivery of tetracycline in relation to overall and local periodontal conditions J Clin Periodontol. 1997 Monbelli A, et al. Local antibiotic therapy guided by microbiological diagnosis. Treatment of Porpyromonas gingivalis and Actinobacillus antinomycetemcomitans persisting after mechanical therapy. 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Effect of non surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. J Periodontol. 2003 Llambés F, Silvestre FJ, Hernández Mijares A, Guiha R, Caffesse R. Effect of non surgical periodontal treatment with or without doxycy- cline on the periodontium of type 1 diabetic patients. J Clin Periodontol. 2005 O'Connell PA, Taba M, Nomizo A, Foss Freitas MC, Suaid FA, Uyemura SA, Trevisan GL, Novaes AB, Souza SL, Palioto DB, Grisi MF. Effects of periodontal therapy on glycemic control and inflammatory markers. J Periodontol. 2008 Slots J, Jorgensen MG. Effective, safe, practical and affordable periodontal antimicrobial therapy where are we going, and are we there yet? Periodontol 2000. 2002 Mombelli A, Samaranayake LP. Topical and systemic antibiotics in the management of periodontal diseases. Int Dent J. 2004 Bidault P, Chandad F, Grenier D. Systemic antibiotic therapy in the treatment of periodontitis. 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Adjunctive effects to non surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controleed study. J Clin Periodontol. 2002 Berglundh T, Krok L, Liljenberg B, Westfelt E, Serino G, Lindhe J. The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease a prospective, controlled clinical trial. J Clin Periodontol. 1998 periodontitis OR periodontal disease antibiotics OR antimicrobial OR systemic administration AND debridement OR scaling and root planning AND clinical trial Herrera D, Alonso B, Leon R, Roldan S and Sanz M. Antimicrobial therapy in periodontitis the use of systemic antimi- crobials against the subgingival biofilm. J Clin Periodontol. 2008 Berglundh T, Krok L, Liljenberg B, Westfelt E, Serino G & Lindhe J. The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease a prospective, controlled clinical trial. J Clin Periodontol. 1998 Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L & Tonetti MS. Adjunctive benefits of systemic amox- icillin and metronidazole in nonsurgical treatment of generalized aggressive periodontitis a randomized placebocon- trolled clinical trial. J Clin Periodontol. 2005 Xajigeorgiou C, Sakellari D, Slini T, Baka A & Konstantinidis A. Clinical and microbiological effects of different antimi- crobials on generalized aggressive periodontitis. J Periodontol. 2006 Ehmke B, Moter A, Beikler T, Milian E & Flemmig TF. Adjunctive antimicrobial therapy of periodontitis effects on disease progression and oral colonization. J Periodontol. 2005 Rooney J, Wade WG, Sprague SV, Newcombe RG. & Addy M. Adjunctive effects to non surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined a placebo controlled study. J Clin Periodontol. 2002 Mascarenhas P, Gapski R, Al Shammari K, Hill R, Soehren S, Fenno JC, Giannobile WV & Wang HL. 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Adjunctive effects to non surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined a placebo controlled study. J Clin Periodontol. 2002 Berglundh T, Krok L, Liljenberg B, Westfelt E, Serino G, Lindhe J. The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial. J Clin Periodontol. 1998 Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, Tonetti MS. Adjunctive benefits of systemic amoxicil- lin and metronidazole in non surgical treatment of generalized aggressive periodontitis a randomized placebo con- trolled clinical trial. J Clin Periodontol. 2005 Flemmig TF, Milián E, Karch H, Klaiber B. Differential clinical treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and or Porphyromonas gingivalis. J Clin Periodontol. 1998 Palmer RM, Matthews JP, Wilson RF. Non surgical periodontal treatment with and without adjunctive metronidazole in smokers and non smokers. J Clin Periodontol. 1999 Kulkarni GV, Lee WK, Aitken S, Birek P, McCulloch CA. A randomized, placebo controlled trial of doxycycline on the microflora of recurrent periodontitis lesions in high risk patients. J Periodontol. 1991 Helldén LB, Listgarten MA, Lindhe J. The effect of tetracycline and or scaling on human periodontal disease. J Clin Periodontol. 1979 Haffajee AD, Torresyap G, Socransky SS. Clinical changes following four different periodontal therapies for the treat- ment of chronic periodontitis 1 year results. J Clin Periodontol. 2007 bleeding on probing BOP periodontitis OR perio- antibiotic OR antimicrobial OR systemic administration OR local administration OR antibacterial agents Purucker P, Mertes H, Goodson JM, Bernimoulin JP. Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis. J Periodontol. 2001 Palmer RM, Matthews JP, Wilson RF. Adjunctive systemic and locally delivered metronidazole in the treatment of perio- a controlled clinical study. Br Dent J. 1998 Kaner D, Bernimoulin JP, Hopfenmuller W, Kleber BM, Friedmann A. Controlled delivery chlorhexidine chip versus amoxicillin metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis control clinical trials. J Clin Periodontol. 2007 periodontitis OR periodontal disease antibiotic OR antimicrobial OR systemic administration OR metronidazole OR amoxycillin OR azithromycine debridement OR scaling and root planning AND clinical trial Herrera D, Sanz M, Jepsen S, Needleman I, Roldan S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol. 2002 Winkel EG, van Winkelhoff AJ, Timmerman MF, van der Velden, van der Weijden GA. Amoxicillin plus metromidazole in the treatment of adult periodontitis patients a double blind placebo controlled study. J Clin Periodontol. 2001 Sigusch B, Beier M, Klinger G, Pfister W, Glockmann E. A 2 step non surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. J Periodontol. 2001 Smith SR, Foyle DM, Daniels J, Joyston Bechal S, Smales FC, Sefton A, Williams J. A double blind placebo controlled trial of azithromycine as an adjunct to non surgical treatment of periodontitis in adults clinical results. J Clin Periodontol. 2002 Guerrero A, Griffiths GS, Nibali L, Survan J, Moles DR, Laurell L, Tonetti MS. Adjunctive benefits of systemic amoxicil- lin and metronidazole in non surgical treatment of generalized aggressive periodontitis a randomized placebo con- trolled clinical trial. J Clin Periodontol. 2005 Rooney J, Wade WG, Sprangue SV, Newcombe RG, Addy M. 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necrotizing ulcerative gingivitis periodontitis evidence based medicine evidence based dentistry for Health Care Policy and Research chemical plaque control chemotherapeutic agent mouth rinse solution, mouth wash solution mechanical plaque control smoking related periodontitis local administration local drug delivery system microbial substitution empiric medication, empiric administration oral administration antibacterial agent, antimicrobial drug antimicrobial sensitivity test minimal inhibitory con- prophylactic antibiotics administration, antibiotic prophylaxis systemic anti infective periodontal therapy, periodontal antimicrobial therapy antimicrobial activity antifungal, antimycotic minimum inhibitory concentration minimum bactericidal concentration bacteriocidal drug supportive periodontal therapy periodontal abscess Porphyromonas gingivalis Tannerella Treponema denticola progression and recurrence of periodontal disease prognosis of periodontal disease administration to periodontal pocket subgingival plaque gingival crevicular fluid topical application on gingiva sustained release preparation, protracted release preparation local drug delivery system aggressive periodontitis mouth rinse solution, mouth wash solution systematic disease related periodontitis multidrug resistant bacteria, multiple drug resistant bacteria treatment resistant periodontitis drug delivery system incurable periodontitis extreme downhill half life, half life period opotunistic infection full mouth disinfection drug sensitivity test drug induced periodontal overgrowth

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Hindawi Publishing CorporationISRN PharmacologyVolume 2014, Article ID 575423, 5 pageshttp://dx.doi.org/10.1155/2014/575423 Research ArticlePromotive Effect of Topical Ketoconazole, Minoxidil, andMinoxidil with Tretinoin on Hair Growth in Male Mice Muhsin A. Aldhalimi,1 Najah R. Hadi,2 and Fadaa A. Ghafil2 1 Department of Dermatology, Kufa College of Medicine, Kufa, Iraq2 Department of Pharmacology and Therapeutics, Kufa College of Medicine, Kufa, Iraq

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