Health Articles

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1. Chemical Product and Company information.
Product name: Caffeine
Contact Information:
Alberton 1454
Telephone : 011 867 3726 / 2864
2. Hazard Identification

Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Severe over-
exposure can result in death.
3. Composition / information on ingredients
CAS #: 58-08-2
Synonym: 1,3,7-trimethylxanthine; 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione, Trimethyl-1,3,7-dioxo-
2,6-purine

Chemical Name: Caffeine
Chemical Formula: C8-H10-N4-O2
4. First Aid Measures
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty
of water for at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention.
Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an
emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes
before reuse. Get medical attention.
Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial
cream. Seek immediate medical attention.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical attention.

Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a
collar, tie, belt or waistband. Seek medical attention.
Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give
anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get
medical attention immediately.
Serious Ingestion: Not available.

5. Fire-fighting measures
Flammability of the Product: May be combustible at high temperature
Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of open
flames and sparks, of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of
mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not
available.
Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water
spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available
Special Remarks on Explosion Hazards: Not available
6. Accidental release measures
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill: Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled
material. Use water spray to reduce vapours. Prevent entry into sewers, basements or confined areas; dike if
needed. Eliminate all ignition sources. Call for assistance on disposal.
7. Handling and storage
Precautions: Keep locked up. Keep away from heat. Keep away from sources of ignition. Empty containers
pose a fire risk; evaporate the residue under a fume hood. Ground all equipment containing material. Do not
ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable
respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid
contact with skin and eyes.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.
8. Exposure controls/personal protection
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep
airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use
ventilation to keep exposure to airborne contaminants below the exposure limit.
Personal Protection: Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator
or equivalent. Gloves.
Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self
contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing
might not be sufficient; consult a specialist BEFORE handling this product.

9. Physical and chemical properties
Physical state and appearance: Solid (Crystalline
Odour Threshold: Not available
Ionicity (in Water): Not available.
Odour: Odourless
Dispersion Properties: See solubility in water,
Taste: Bitter (Slight)
Colour: White
Solubility: Soluble in hot water. Partially soluble in
cold water, acetone. Very slightly soluble in diethyl Boiling Point: Not available
ether. Freely soluble in pyrrole; in tetrahydrofuran containing about 4% water. Soluble in pyridine, ethyl Melting Point: 238°C
acetate. Partially soluble in alcohol Slightly soluble in petroleum ether. Solubility in water is increased by Critical Temperature: Not available
alkali benzoates, cinnamates, citrates or salicylates
Specific Gravity: 1.23 (Water = 1)
Vapour Density: Not available
Volatility: Not available

10. Stability and reactivity
Stability: The product is stable
Instability Temperature: Not available.
Conditions of Instability: Excess heat
Incompatibility with various substances: Not available
Corrosivity: Non-corrosive in presence of glass
Special Remarks on Reactivity: Not available
Special Remarks on Corrosivity: Not available
Polymerization: Will not occur.
11. Toxicological information
Routes of Entry: Inhalation. Ingestion

Toxicity to Animals: Acute oral toxicity (LD50): 127 mg/kg [Mouse].
Chronic Effects on Humans: CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC.
MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May
cause damage to the following organs: heart, gastrointestinal tract, central nervous system (CNS).
Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: LDL [Human] - Route: Oral; Dose: 192mg/kg LDL [Woman] -
Route: Oral; Dose; 400 mg/kg LDL [Child] - Route: Oral; Dose: 320 mg/kg
Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects (fetotoxicity,
maternal (parnutrition) and birth defects. May affect genetic material (mutagenic). May cause cancer

(tumorgenic) based on animal data.
Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: May cause skin
irritation. Eyes: Dust may cause mechanical irritation. Inhalation: May cause respiratory tract irritation.
Ingestion: Harmful if swallowed in large amounts. May cause gastrointestinal (digestive) tract irritation with
epigastric pain, abdominal cramps, nausea, vomiting and diarrhoea. Affects metabolism and cardiovascular
system with symptoms including increase in metabolism, flushing, palpitations, rapid heart rate, dysrhythmias,
hypotension, blood pressure elevation and weight loss, metabolic acidosis. May affect brain and
behaviour/central nervous system. Symptoms may include nervousness, anxiety, restlessness, insomnia,
dizziness, tremor, seizures, convulsions, hallucinations, somnolence, toxic psychosis, tremors, convulsions,
ataxia. May also affect blood, respiration (hyperventilation), and urinary system (mild increase in urinary
volume and urinary sodium excretion), and may directly produce hypokalemia. Chronic Potential Health
Effects: May cause cancer (tumorigen) based on animal studies. May cause reproductive and foetal effects. May
cause digestive tract disturbances (increased gastric acid, and pepsin secretion and a decrease in lower
oesophageal sphincter pressure), cardiovascular disturbances. Since it is a CNS stimulant, it may also affect the
Central Nervous System (CNS).
12. Ecological information
Ecotoxicity: Not available
BOD5 and COD: Not available
Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long
term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available

13. Disposal considerations
Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control
regulations.

14. Transport information
DOT Classification: CLASS 6.1: Poisonous material.
Identification: : Alkaloid, solid, n.o.s. (Caffeine) UNNA: 1544 PG: III
Special Provisions for Transport: Not available

The information above is believed to be accurate and represents the best information currently available to us.
However, we make no warranty of merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users should make their own investigations
to determine the suitability of the information for their particular purposes. In no event shall Radchem CC. be
liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental,
consequential or exemplary damages, howsoever arising, even if Radchem CC has been advised of the
possibility of such damages.

Source: http://cdn2.lasecsa.co.za/pdf/sds/CAFFEINE%20MSDS.pdf