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Nipponkayaku.co.jp









The KAYAKU spirit represents Nippon Kayaku Group's corporate
vision - the ultimate goal of all its corporate activities.
We fulfill our social responsibilities as part of our corporate efforts to realize
the KAYAKU spirit. These efforts are based on the standards of conduct
articulated in the Group Action Guidelines and in the Nippon Kayaku Group
Kayaku Suppor ts.
Charter of Conduct and Code of Conduct.
Group ACTION Guidelines
For the Nippon Kayaku Group, At Nippon Kayaku Group, we corporation manufacturing industrial explosives, it has since society with the best products believe in doing more than through ceaseless progress means aiming to realize the launched various technologies and diverse products . The and the combined forces of KAYAKU spirit and being a
motions of our work. When we "good and strong company" to act, our aim is to think about fulfill our social, economic and the value we each individually continue to suppor t convenience, comfor t, confidence and safety for people's lives. At their root is the ideal of "serving society with products that enhance human happiness." Moving into the future, Nippon Kayaku continues to embrace this ideal.
Goal of corporate
Continuously providing society with the best products through ceaseless progress and the combined forces of our consciences.
Business plans and business activities, activities that contribute to Corporate activities to society and local communities, realize the KAYAKU spirit
activities that reduce environmental impact Nippon Kayaku Group Charter of
Standards of
Conduct and Code of Conduct
Corporate Slogan. The term "sukima" is Japanese
for "niche," meaning a place whose value is still
Group Action Guidelines
Policy on attitude undiscovered and unexploited. At Nippon Kayaku,
1 Keep the KAYAKU spirit in mind at all times.
our aim is to be No. 1 globally in niche markets, not
2 Implement PDCA in a thorough, timely manner*1.
3 Everyone has a place in the driver's seat*2.
technology to provide high added-value products
that the world needs.

*1、PDCA: Plan → Do → Check → Act*2、In other words, each person acts independently The KAYAKU spirit represents Nippon Kayaku Group's corporate
vision - the ultimate goal of all its corporate activities.
We fulfill our social responsibilities as part of our corporate efforts to realize
the KAYAKU spirit. These efforts are based on the standards of conduct
articulated in the Group Action Guidelines and in the Nippon Kayaku Group
Kayaku Suppor ts.
Charter of Conduct and Code of Conduct.
Group ACTION Guidelines
For the Nippon Kayaku Group, At Nippon Kayaku Group, we corporation manufacturing industrial explosives, it has since society with the best products believe in doing more than through ceaseless progress means aiming to realize the launched various technologies and diverse products . The and the combined forces of KAYAKU spirit and being a
motions of our work. When we "good and strong company" to act, our aim is to think about fulfill our social, economic and the value we each individually continue to suppor t convenience, comfor t, confidence and safety for people's lives. At their root is the ideal of "serving society with products that enhance human happiness." Moving into the future, Nippon Kayaku continues to embrace this ideal.
Goal of corporate
Continuously providing society with the best products through ceaseless progress and the combined forces of our consciences.
Business plans and business activities, activities that contribute to Corporate activities to society and local communities, realize the KAYAKU spirit
activities that reduce environmental impact Nippon Kayaku Group Charter of
Standards of
Conduct and Code of Conduct
Corporate Slogan. The term "sukima" is Japanese
for "niche," meaning a place whose value is still
Group Action Guidelines
Policy on attitude undiscovered and unexploited. At Nippon Kayaku,
1 Keep the KAYAKU spirit in mind at all times.
our aim is to be No. 1 globally in niche markets, not
2 Implement PDCA in a thorough, timely manner*1.
3 Everyone has a place in the driver's seat*2.
technology to provide high added-value products
that the world needs.

*1、PDCA: Plan → Do → Check → Act*2、In other words, each person acts independently As we seek to be No. 1 globally in niche markets, Nippon Kayaku Supporting Everything from
sees func tional chemicals, pharmaceuticals and safet y systems as People's Lifestyles to Industries.
growth industries and runs its business with "global ‘sukima' ideas." Functional Chemicals
Safety Systems Business
Nippon Kayaku has a long history in In three business areas̶functional the development and manufactur- materials, color materials and cata- ing of explosives and pyrotechnic lysts̶Nippon Kayaku handles vari- devices, together with a wide range ous produc ts and components of technologies. By applying these using our resin, dye and catalyst technologies, we have developed technologies. These products are We specialize in cancer-related original automobile airbag inflators, Agrochemicals Business
used in a wide range of applica- products, putting our many years of micro gas generators that tighten and Other
tions, especially the field of elec- development and manufacturing seatbelts in the event of a collision, tronics. In quick-changing markets, know-how to work to handle prod- and ignition devices called squibs Nippon Kayaku runs agrochemical Nippon Kayaku uses technologies at ucts from new pharmaceuticals to that are a key component of these. and real estate businesses. Our which we excel to create businesses generics and provide medical insti- We contribute to enhancing safety agrochemical business handles that demonstrate our strengths.
tutions with the reliable informa- in automobile societies by providing products necessary for a stable tion they need about anti-cancer such products to the global market.
food supply. With a product line drugs. With specialty, biosimilar featuring agricultural insecticides, generic and IVR (*1) products as our herbicides, fungicides and soil core businesses, we will continue to fumigants, we handle insecticides strive to "help enhance patient QOL for public health (e.g., flies, mosqui- (*2) as a partner to health care pro- toes and cock roaches) and are viders in the cancer-related field." expanding our variations on agri- *1、Interventional radiology: An endovascular therapy cultural chemicals.
that places less burden on the patient being treated *2、Quality of life As we seek to be No. 1 globally in niche markets, Nippon Kayaku Supporting Everything from
sees func tional chemicals, pharmaceuticals and safet y systems as People's Lifestyles to Industries.
growth industries and runs its business with "global ‘sukima' ideas." Functional Chemicals
Safety Systems Business
Nippon Kayaku has a long history in In three business areas̶functional the development and manufactur- materials, color materials and cata- ing of explosives and pyrotechnic lysts̶Nippon Kayaku handles vari- devices, together with a wide range ous produc ts and components of technologies. By applying these using our resin, dye and catalyst technologies, we have developed technologies. These products are We specialize in cancer-related original automobile airbag inflators, Agrochemicals Business
used in a wide range of applica- products, putting our many years of micro gas generators that tighten and Other
tions, especially the field of elec- development and manufacturing seatbelts in the event of a collision, tronics. In quick-changing markets, know-how to work to handle prod- and ignition devices called squibs Nippon Kayaku runs agrochemical Nippon Kayaku uses technologies at ucts from new pharmaceuticals to that are a key component of these. and real estate businesses. Our which we excel to create businesses generics and provide medical insti- We contribute to enhancing safety agrochemical business handles that demonstrate our strengths.
tutions with the reliable informa- in automobile societies by providing products necessary for a stable tion they need about anti-cancer such products to the global market.
food supply. With a product line drugs. With specialty, biosimilar featuring agricultural insecticides, generic and IVR (*1) products as our herbicides, fungicides and soil core businesses, we will continue to fumigants, we handle insecticides strive to "help enhance patient QOL for public health (e.g., flies, mosqui- (*2) as a partner to health care pro- toes and cock roaches) and are viders in the cancer-related field." expanding our variations on agri- *1、Interventional radiology: An endovascular therapy cultural chemicals.
that places less burden on the patient being treated *2、Quality of life Functional Chemicals Business ■Functional Materials Business
Epoxy resins and hardeners for encapsulation of semiconductor device printed circuit board UV-curing resin for In our Functional Materials Business, we are involved with materials that have a broad range of functions, including epoxy resins that serve as an insulating material for semiconductor encapsulation, UV-curable resins, and polyimide/polyamide resins that are noted for their high durability. In particular, environmentally friendly epoxy resins have been established as the de facto standard in the Supporting Society and Industry
market.
In addition, we are also developing high value added products for use in a wide range of fields, such as resin composites, including Within our functional chemicals business we handle functional materials, color LCD panel sealants and microelectromechanical systems (MEMS), materials, and catalysts. Functional materials cover a variety of functions that combine our proprietary resin materials with our structuring especially for the electronics field, including epoxy resins, UV-curing resins, and other resin materials. Color materials include textiles, paper, with high added-value, such as colorants for inkjet printer inks. Products from our catalyst business are used for the production of acrylic acid and methacrylic acid. With this blending of new and long-established technologies, we create products Sealants for LCD panels designed to help protect the environment and save energy.
"Sukima" of tomorrow: "thermal conductive sheets"
Rediscovering our roots: 1916
You may have heard of thermal conductive sheets. As house- Adhesive sheet with
hold appliances and automobiles become higher performance, high heat resistance and
Since the launch of the first full-color inkjet printers in the early high thermal conductivity
more heat is generated by their semiconductor devices, and 1990s, many types of dyes and pigments have found use as ink rising temperatures make people worry that their products may colorants. With our lineup of numerous products and our colo- malfunction. Nippon Kayaku develops thermal conductive rant synthesizing technology (backed by over nine decades of sheets to transfer semiconductor device heat to heat-dissipat- history since Teikoku Senryo Seizo Co., Ltd. was founded in ing materials stably and efficiently over the long term.
1916), we have developed outstanding colorfast water-soluble dyestuff for inkjet photo printing and developed pigment slurry using new dispersion technology as we continue to advance inkjet technology.
Functional Chemicals Business ■Functional Materials Business
Epoxy resins and hardeners for encapsulation of semiconductor device printed circuit board UV-curing resin for In our Functional Materials Business, we are involved with materials that have a broad range of functions, including epoxy resins that serve as an insulating material for semiconductor encapsulation, UV-curable resins, and polyimide/polyamide resins that are noted for their high durability. In particular, environmentally friendly epoxy resins have been established as the de facto standard in the Supporting Society and Industry
market.
In addition, we are also developing high value added products for use in a wide range of fields, such as resin composites, including Within our functional chemicals business we handle functional materials, color LCD panel sealants and microelectromechanical systems (MEMS), materials, and catalysts. Functional materials cover a variety of functions that combine our proprietary resin materials with our structuring especially for the electronics field, including epoxy resins, UV-curing resins, and other resin materials. Color materials include textiles, paper, with high added-value, such as colorants for inkjet printer inks. Products from our catalyst business are used for the production of acrylic acid and methacrylic acid. With this blending of new and long-established technologies, we create products Sealants for LCD panels designed to help protect the environment and save energy.
"Sukima" of tomorrow: "thermal conductive sheets"
Rediscovering our roots: 1916
You may have heard of thermal conductive sheets. As house- Adhesive sheet with
hold appliances and automobiles become higher performance, high heat resistance and
Since the launch of the first full-color inkjet printers in the early high thermal conductivity
more heat is generated by their semiconductor devices, and 1990s, many types of dyes and pigments have found use as ink rising temperatures make people worry that their products may colorants. With our lineup of numerous products and our colo- malfunction. Nippon Kayaku develops thermal conductive rant synthesizing technology (backed by over nine decades of sheets to transfer semiconductor device heat to heat-dissipat- history since Teikoku Senryo Seizo Co., Ltd. was founded in ing materials stably and efficiently over the long term.
1916), we have developed outstanding colorfast water-soluble dyestuff for inkjet photo printing and developed pigment slurry using new dispersion technology as we continue to advance inkjet technology.
■Color Materials Business
■Polatechno Co., Ltd.
Nippon Kayaku is pursuing the possibilities of dyes. As Japan's largest Nippon Kayaku's consolidated subsidiary Polatechno Co., Ltd. manufactures dye manufacturer, we are always at the forefront of the industry. To specialty polarizing films essential for LCD panel displays. These dye-type meet the needs of customers, which change with time, we develop polarizing films are ideal for niche characteristic and unique dyes, including those that are vivid in color, markets that demand a great deal of those that do not fade (colorfast) and those that are easy to handle. We durability, such as small and medium deliver a wide range of products to market, including textiles, paper, sized panels for automobiles and LCD resin coloring, and inkjet printers.
Components for LCD projectors The company is committed to the creation of materials with features that can contribute to society in a variety of areas. This is done by utiliz- ■Nippon Kayaku in your life
ing Nippon Kayaku's printing and optical evaluation technologies, including resisting, dispersion, and synthesis technologies developed over many years in its colorant business. These consist of various func-tional coloring materials such as infrared absorbing agents, color resists for image sensors, pigment derivatives (synergists), Materials for ther- mal paper such as overcoat agents, and developer.
Dyes for Textiles Colorants for inkjet printers Catalysts are highly important materials that are used in the manufacture of raw materi-als for many of the finished products we see around us every day. The quality of the cata-lysts controls the production cost, and consequently, has a considerable impact on the price of the finished products. Nippon Kayaku has been developing, manufacturing, and Semiconductor encapsulator When liquid cr ys t als are Durable dyes are used to R e s i s t i n k s , w h i c h a r e sel ing catalysts for the production of acrylic acid and methacrylic acid (by direct oxida- epoxy resin is used to protect, injected between sheets of c o l o r t h e i n k f o r c o l o r UV-curing resins, are used in tion method). These products have been highly rated by our insulate and keep moisture glass, sealants for LCD panels inkjet printers.
digital camera image sen- away from the semiconduc- are used as adhesive holding customers. Acrylic acid finds use as raw material in the pro- tors of PCs and other elec- the glass together.
duction of super absorbent polymers used in disposable tronic and information equip-ment.
diapers, etc., acrylic paints, and adhesives.
Methacrylic acid is used in light-guide plate and other opti- Substances like iodine and dyestuffs are caused to adsorb and Catalysts are used to produce Dyestuffs are used that make cal applications, as well as in products such as transparent orient themselves in polyvinyl alcohol. The resulting polarizing acrylic acid, a raw material of fibers, resins and other mate- plastics used for giant aquarium tank.
film is used to allow light of only a certain direction to pass. rials colorful.
■Color Materials Business
■Polatechno Co., Ltd.
Nippon Kayaku is pursuing the possibilities of dyes. As Japan's largest Nippon Kayaku's consolidated subsidiary Polatechno Co., Ltd. manufactures dye manufacturer, we are always at the forefront of the industry. To specialty polarizing films essential for LCD panel displays. These dye-type meet the needs of customers, which change with time, we develop polarizing films are ideal for niche characteristic and unique dyes, including those that are vivid in color, markets that demand a great deal of those that do not fade (colorfast) and those that are easy to handle. We durability, such as small and medium deliver a wide range of products to market, including textiles, paper, sized panels for automobiles and LCD resin coloring, and inkjet printers.
Components for LCD projectors The company is committed to the creation of materials with features that can contribute to society in a variety of areas. This is done by utiliz- ■Nippon Kayaku in your life
ing Nippon Kayaku's printing and optical evaluation technologies, including resisting, dispersion, and synthesis technologies developed over many years in its colorant business. These consist of various func-tional coloring materials such as infrared absorbing agents, color resists for image sensors, pigment derivatives (synergists), Materials for ther- mal paper such as overcoat agents, and developer.
Dyes for Textiles Colorants for inkjet printers Catalysts are highly important materials that are used in the manufacture of raw materi-als for many of the finished products we see around us every day. The quality of the cata-lysts controls the production cost, and consequently, has a considerable impact on the price of the finished products. Nippon Kayaku has been developing, manufacturing, and Semiconductor encapsulator When liquid cr ys t als are Durable dyes are used to R e s i s t i n k s , w h i c h a r e sel ing catalysts for the production of acrylic acid and methacrylic acid (by direct oxida- epoxy resin is used to protect, injected between sheets of c o l o r t h e i n k f o r c o l o r UV-curing resins, are used in tion method). These products have been highly rated by our insulate and keep moisture glass, sealants for LCD panels inkjet printers.
digital camera image sen- away from the semiconduc- are used as adhesive holding customers. Acrylic acid finds use as raw material in the pro- tors of PCs and other elec- the glass together.
duction of super absorbent polymers used in disposable tronic and information equip-ment.
diapers, etc., acrylic paints, and adhesives.
Methacrylic acid is used in light-guide plate and other opti- Substances like iodine and dyestuffs are caused to adsorb and Catalysts are used to produce Dyestuffs are used that make cal applications, as well as in products such as transparent orient themselves in polyvinyl alcohol. The resulting polarizing acrylic acid, a raw material of fibers, resins and other mate- plastics used for giant aquarium tank.
film is used to allow light of only a certain direction to pass. rials colorful.
Pharmaceuticals Business ■Scope of indications
Nippon Kayaku has the biggest anti-cancer line-up of any Japanese pharmaceutical manufacturer, with drugs indicated for cancers in almost all organs of the body.
BrainHead and neck Supporting modern medical care
Nippon Kayaku's history in the anti-cancer field started with the launch of BLEO- Bile ductPancreas CIN (Bleomycin) in 1969, and Nippon Kayaku currently has the biggest anti- cancer line-up of any Japanese pharmaceutical company. On the basis of Nippon Kayaku's network of cancer-specialist medical representatives, highly reliable information can be rapidly provided to physicians, pharmacists and nurses at clinical institutions. In terms of specialty pharmaceuticals that have made signifi- cant contributions to cancer treatment, in addition to drugs developed in-house, and cancer-related generics suited to current needs, Nippon Kayaku has, as the third pillar of its business, made progress in the field of interventional radiology, which offers less invasive treatments for patients. Nippon Kayaku is also aspiring to make even greater contributions to society through biosimilars, which reduces the burden on patients and the strains on medical costs.
Other parts of the body and fields of application Rediscovering our roots: 1931
Yamakawa Seiyaku Co., Ltd. was founded in 1931 for the purpose of Hematopoietic system aspirin manufacture, and became an important company. At that time, aspirin was imported, but the Japanese government urged domestic manufacture of a number of important drugs, among which demand was greatest for aspirin. In 1933, Yamakawa Seiyaku Co., Ltd., having overcome various difficulties, succeeded with domestic manufacture, and Yamakawa aspirin tablets were launched. In 1943, Yamakawa Seiyaku Co., Ltd. merged with Nippon Kayaku Seizo Co., Ltd. to form Nippon Kayaku Co., Ltd.
Pharmaceuticals Business ■Scope of indications
Nippon Kayaku has the biggest anti-cancer line-up of any Japanese pharmaceutical manufacturer, with drugs indicated for cancers in almost all organs of the body.
BrainHead and neck Supporting modern medical care
Nippon Kayaku's history in the anti-cancer field started with the launch of BLEO- Bile ductPancreas CIN (Bleomycin) in 1969, and Nippon Kayaku currently has the biggest anti- cancer line-up of any Japanese pharmaceutical company. On the basis of Nippon Kayaku's network of cancer-specialist medical representatives, highly reliable information can be rapidly provided to physicians, pharmacists and nurses at clinical institutions. In terms of specialty pharmaceuticals that have made signifi- cant contributions to cancer treatment, in addition to drugs developed in-house, and cancer-related generics suited to current needs, Nippon Kayaku has, as the third pillar of its business, made progress in the field of interventional radiology, which offers less invasive treatments for patients. Nippon Kayaku is also aspiring to make even greater contributions to society through biosimilars, which reduces the burden on patients and the strains on medical costs.
Other parts of the body and fields of application Rediscovering our roots: 1931
Yamakawa Seiyaku Co., Ltd. was founded in 1931 for the purpose of Hematopoietic system aspirin manufacture, and became an important company. At that time, aspirin was imported, but the Japanese government urged domestic manufacture of a number of important drugs, among which demand was greatest for aspirin. In 1933, Yamakawa Seiyaku Co., Ltd., having overcome various difficulties, succeeded with domestic manufacture, and Yamakawa aspirin tablets were launched. In 1943, Yamakawa Seiyaku Co., Ltd. merged with Nippon Kayaku Seizo Co., Ltd. to form Nippon Kayaku Co., Ltd.
■Principal pharmaceutical fields
"Sukima" of tomorrow: Polymeric micelle anti-cancer drugs
Ethical drugs for Japanese use
Polymeric micelle anti-cancer drugs have greater efficacy than other drugs, and progress is being made with their development for use in a novel nanomedicine drug-delivery Since entering the anti-cancer field with the launch of BLEOCIN, Nippon Kayaku system (DDS) in which anti-cancer drugs, which tend to have adverse effects, are selec- has provided various types of drug products. Nippon Kayaku has an excellent tively concentrated in cancer tissues, in order to achieve sufficient anti-cancer efficacy at line-up of cancer-related drugs, and has strengths with respect to information the same time as reduced adverse effects.
accumulation, and know-how. With the aim of increasing the quality of life of cancer patients, in partnership with health-care professionals, Nippon Kayaku Polymeric micelle anti-cancer drugs
Sequence in drug-delivery system
has established a nationwide network of cancer-specialist medical representa- tives, and Pharmaceutical Information Centers. Nippon Kayaku has also set up an organization for providing clinical institutions with information about correct Core: Anti-cancer drug drug use, for use in responses to questions from people involved with treat- ment, and to support aspects of treatment. In addition, interventional radiol- ogy, which is a low-invasiveness technique for treatment by internal, especially intravenous, routes, using diagnostic imaging devices, catheters, etc., is now positioned as an important new field, and, despite this being a niche area, sig- nificant contributions are expected with development of embolic beads, etc.
Bulk drug and export activities
The bulk drug side of Nippon Kayaku's business involves contract manufacture Shel : Amphiphilic Escape from blood vessel of bulk drugs and intermediates, using fermentation technology, and also pro- duction techniques for highly active substances, which were developed for anti-cancer drugs.
Q1: What are polymeric micel e anti-cancer drugs? Q2:Is it the case that polymeric micelle The export side of the business involves exportation of bleomycin and other A:Polymeric micelle anti-cancer drugs are nanoparticles anti-cancer drugs are not degraded anti-cancer drugs to more than 50 countries, including the EU, Russia and the 20 to 100 nm in diameter, in which a low-molecular- inside blood vessels, and concentrate rest of the former USSR, the Middle East, and Asia.
weight anti-cancer drug is entirely enclosed and sepa- in the cancer tissues? rated from the external environment by string-like large polymers. Each large polymer is constructed with A:These drugs are covered with polyethylene glycol, a hydrophilic moiety, polyethylene glycol, at the exter- which is hydrophilic, resulting in high retentivity in nal end, and a hydrophobic moiety at the internal end. the bloodstream, and prolonged circulation within Nippon Kayaku is involved in the development, manufacture and marketing of Each "string" has a molecular weight of tens of thou- the body. Neovessels in cancer tissues are highly sand units, and their aggregation results in weights of permeable, and lymph ducts are not formed, so the extracorporeal diagnostic drugs for use in clinical laboratory tests required for millions of units.
mechanism for collection of substances is incomplete, diagnosis and treatment of diseases. Nippon Kayaku's activities are focused and substances are absorbed specifically, in accor- mainly on tumor-markers and other drugs for the cancer field, but Nippon dance with polymer size, and they have the potential Kayaku is also involved with diabetes-related drugs, with commercial activities to accumulate.
not being restricted to Japan, but extending throughout the world, and espe- Drug-delivery and -release systems (DDRS)
cially in the USA.
Cancer tissue Capillary Q3:How are anti-cancer drugs released A: Polymeric micelle anti-cancer drugs are relatively An affiliated company, Nippon Kayaku Food Techno Co, Ltd., manufactures and stable in water, and in blood vessels, but aggrega-tions surrounding cancer tissues gradually break markets ethanol-based products for improving food storage, quality- down, and the anti-cancer drugs are thus released. maintaining agents for suppressing growth of mold and microorganisms in This is a more advanced DDS mechanism, also termed food, cleansers/disinfectants for maintaining hygiene in food production envi- ronments, foods for specified health uses, and ingredients of health foods. Advanced technologies developed for drug production are also applicable to the food industry, and, by establishing an environment with hygiene control, anti-cancer drug they enable the best products to be supplied to society, supporting the modern demand for safe and healthy food.
■Principal pharmaceutical fields
"Sukima" of tomorrow: Polymeric micelle anti-cancer drugs
Ethical drugs for Japanese use
Polymeric micelle anti-cancer drugs have greater efficacy than other drugs, and progress is being made with their development for use in a novel nanomedicine drug-delivery Since entering the anti-cancer field with the launch of BLEOCIN, Nippon Kayaku system (DDS) in which anti-cancer drugs, which tend to have adverse effects, are selec- has provided various types of drug products. Nippon Kayaku has an excellent tively concentrated in cancer tissues, in order to achieve sufficient anti-cancer efficacy at line-up of cancer-related drugs, and has strengths with respect to information the same time as reduced adverse effects.
accumulation, and know-how. With the aim of increasing the quality of life of cancer patients, in partnership with health-care professionals, Nippon Kayaku Polymeric micelle anti-cancer drugs
Sequence in drug-delivery system
has established a nationwide network of cancer-specialist medical representa- tives, and Pharmaceutical Information Centers. Nippon Kayaku has also set up an organization for providing clinical institutions with information about correct Core: Anti-cancer drug drug use, for use in responses to questions from people involved with treat- ment, and to support aspects of treatment. In addition, interventional radiol- ogy, which is a low-invasiveness technique for treatment by internal, especially intravenous, routes, using diagnostic imaging devices, catheters, etc., is now positioned as an important new field, and, despite this being a niche area, sig- nificant contributions are expected with development of embolic beads, etc.
Bulk drug and export activities
The bulk drug side of Nippon Kayaku's business involves contract manufacture Shel : Amphiphilic Escape from blood vessel of bulk drugs and intermediates, using fermentation technology, and also pro- duction techniques for highly active substances, which were developed for anti-cancer drugs.
Q1: What are polymeric micel e anti-cancer drugs? Q2:Is it the case that polymeric micelle The export side of the business involves exportation of bleomycin and other A:Polymeric micelle anti-cancer drugs are nanoparticles anti-cancer drugs are not degraded anti-cancer drugs to more than 50 countries, including the EU, Russia and the 20 to 100 nm in diameter, in which a low-molecular- inside blood vessels, and concentrate rest of the former USSR, the Middle East, and Asia.
weight anti-cancer drug is entirely enclosed and sepa- in the cancer tissues? rated from the external environment by string-like large polymers. Each large polymer is constructed with A:These drugs are covered with polyethylene glycol, a hydrophilic moiety, polyethylene glycol, at the exter- which is hydrophilic, resulting in high retentivity in nal end, and a hydrophobic moiety at the internal end. the bloodstream, and prolonged circulation within Nippon Kayaku is involved in the development, manufacture and marketing of Each "string" has a molecular weight of tens of thou- the body. Neovessels in cancer tissues are highly sand units, and their aggregation results in weights of permeable, and lymph ducts are not formed, so the extracorporeal diagnostic drugs for use in clinical laboratory tests required for millions of units.
mechanism for collection of substances is incomplete, diagnosis and treatment of diseases. Nippon Kayaku's activities are focused and substances are absorbed specifically, in accor- mainly on tumor-markers and other drugs for the cancer field, but Nippon dance with polymer size, and they have the potential Kayaku is also involved with diabetes-related drugs, with commercial activities to accumulate.
not being restricted to Japan, but extending throughout the world, and espe- Drug-delivery and -release systems (DDRS)
cially in the USA.
Cancer tissue Capillary Q3:How are anti-cancer drugs released A: Polymeric micelle anti-cancer drugs are relatively An affiliated company, Nippon Kayaku Food Techno Co, Ltd., manufactures and stable in water, and in blood vessels, but aggrega-tions surrounding cancer tissues gradually break markets ethanol-based products for improving food storage, quality- down, and the anti-cancer drugs are thus released. maintaining agents for suppressing growth of mold and microorganisms in This is a more advanced DDS mechanism, also termed food, cleansers/disinfectants for maintaining hygiene in food production envi- ronments, foods for specified health uses, and ingredients of health foods. Advanced technologies developed for drug production are also applicable to the food industry, and, by establishing an environment with hygiene control, anti-cancer drug they enable the best products to be supplied to society, supporting the modern demand for safe and healthy food.
Safety Systems Business (including inflator) An inflator is a gas generator that inflates the air bag. Nippon Kayaku started with inflators for driver's seat and passenger seat applications, and later expanded our scope to add inflators for side air bags, curtain air bags, and knee air bags to our portfolio. We continue to develop new products, to enhance the safety of vehicles.
Seatbelt pretensioner (including micro gas generator) 1 The Collision sensor is a device embedded in the front portion of the vehicle, which detects collisions.
A squib is an ignition part embedded in inflators and 2 The Diagnostic device determines whether micro gas generators. When the sensor detects a colli- a collision is caused by an accident or not.
Our modern automobile society sometimes has to balance safety with sion, an electric current is sent to the squib, and then the 3 When determined as an accident, other concerns. For example, the amount of traffic is increasing, and heat that is generated ignites the agent inside the squib, an electrical signal is relayed to the squib.
4 The squib's explosive agent is ignited automobiles are being made lighter to enhance fuel efficiency. These leading to its activation. Upon activation, the ignition by the relayed electrical signal.
and heat from the squib is transferred to the gas generat- 5 Gas generating agent is ignited, ing agent of the inflator or micro gas generator which and gas is generated.
generates the gas used to propel the device.
6 When the "airbag" is inflated, the "seatbelt pretensioner" retracts the seatbelt, absorbing safet y and evolution of the automobile societ y by developing , manu - the shock received by the passenger.
facturing and selling airbag inflators and micro gas generators, which *This process from 1 to 6 is completed in about 0.05 seconds.
are essential components of airbags and seatbelt pretensioners that support passenger's safety.
Micro Gas Generators
  for seatbelt pretensioner

A micro gas generator is a device that acts to retract the Electrical signal seatbelt (seatbelt pretensioner) in the event of a col ision. Rediscovering our roots: 1916
The retraction of the seatbelt fixes the body to the ideal position in relation to the inflated airbag. This increases Nippon Kayaku has a long history of developing, the effectiveness of the airbag, maximizing the safety for manufacturing and selling dynamite and electric the passenger. As a safety device during an accident, its detonators since our start as the first Japanese industrial additional usages are being put in place, such as the shift- explosives manufacturer in 1916. We have made full use ing of the headrests or seats, or a system where the front of our technologies and know-how in a unique blending hood is popped up to protect pedestrians.
Seatbelt pretensioner retracts of mechanics and chemistry (especially explosives) to design, develop and manufacture airbag inflators and other automotive safety devices.
Safety Systems Business (including inflator) An inflator is a gas generator that inflates the air bag. Nippon Kayaku started with inflators for driver's seat and passenger seat applications, and later expanded our scope to add inflators for side air bags, curtain air bags, and knee air bags to our portfolio. We continue to develop new products, to enhance the safety of vehicles.
Seatbelt pretensioner (including micro gas generator) 1 The Collision sensor is a device embedded in the front portion of the vehicle, which detects collisions.
A squib is an ignition part embedded in inflators and 2 The Diagnostic device determines whether micro gas generators. When the sensor detects a colli- a collision is caused by an accident or not.
Our modern automobile society sometimes has to balance safety with sion, an electric current is sent to the squib, and then the 3 When determined as an accident, other concerns. For example, the amount of traffic is increasing, and heat that is generated ignites the agent inside the squib, an electrical signal is relayed to the squib.
4 The squib's explosive agent is ignited automobiles are being made lighter to enhance fuel efficiency. These leading to its activation. Upon activation, the ignition by the relayed electrical signal.
and heat from the squib is transferred to the gas generat- 5 Gas generating agent is ignited, ing agent of the inflator or micro gas generator which and gas is generated.
generates the gas used to propel the device.
6 When the "airbag" is inflated, the "seatbelt pretensioner" retracts the seatbelt, absorbing safet y and evolution of the automobile societ y by developing , manu - the shock received by the passenger.
facturing and selling airbag inflators and micro gas generators, which *This process from 1 to 6 is completed in about 0.05 seconds.
are essential components of airbags and seatbelt pretensioners that support passenger's safety.
Micro Gas Generators
  for seatbelt pretensioner

A micro gas generator is a device that acts to retract the Electrical signal seatbelt (seatbelt pretensioner) in the event of a col ision. Rediscovering our roots: 1916
The retraction of the seatbelt fixes the body to the ideal position in relation to the inflated airbag. This increases Nippon Kayaku has a long history of developing, the effectiveness of the airbag, maximizing the safety for manufacturing and selling dynamite and electric the passenger. As a safety device during an accident, its detonators since our start as the first Japanese industrial additional usages are being put in place, such as the shift- explosives manufacturer in 1916. We have made full use ing of the headrests or seats, or a system where the front of our technologies and know-how in a unique blending hood is popped up to protect pedestrians.
Seatbelt pretensioner retracts of mechanics and chemistry (especially explosives) to design, develop and manufacture airbag inflators and other automotive safety devices.
Agrochemicals Business ■Agrochemical Business products
We offer agricultural chemicals that bring together our production technology
and know-how and meet the needs of the times.

Insecticide DIAZINON CS "DIAZINON SL SOL"
Japan's first microencapsulated agricultural chemical. It has long-lasting effectiveness and
is highly safe.
Soil fumigant CHLOROPICRIN EC "CHLOPIC FLOW"
This improved new chemical mixes chloropicrin, which is hard to handle by itself, with
water, resulting in a product that is easy to process with less irritation when processing
but has stable effectiveness.
Successive innovations have led to other products such as CYCLOPROTHRIN
Supporting Food and Agriculture
G "CYCLO PACK" (a labor-saving insecticide that spreads by itself), spltNPV
WP "HASUMON TENTEKI" (a biological pesticide using a virus that selec-

Without food, there would be no life. The farm is where food is produced. tively infects insects), and WIDE COAT (a new type of adjuvant that improves
both spreadability and sticking power of agricultural chemicals).

The world's population is rising rapidly and demand for food is growing globally. Thus our world needs a safe and stable supply of food we can Insecticides for public health
count on into the future. This requires agrochemicals that are good for the We offer chemicals to protect from hygiene pests like flies, mosquitoes, cockroaches,
environment and suited for today's agricultural patterns, which include ticks and mites.
older farmers and people working side jobs. Using our fine chemicals exper- Insecticide PROPETAMPHOS CS "SAFROTIN MC"
tise, we develop, manufacture and sell insecticides, fungicides, herbicides, Safrotin, which has long been used to protect form hygiene pests, now comes in microcapsule soil fumigants, plant growth regulators and insecticides for public health, form. It has long-lasting effectiveness and is highly safe. It is particularly effective against cock-roaches, since the capsules break down the special structure of their digestive tracts.
among others. By supplying chemicals that meet the needs of the times, we support people's lifestyles.
Animal repellent R-731
This animal repellent contains microcapsules of capsaicin, the sharp-tasting compo-
nent of chili peppers. Kneaded into cables and other goods, it prevents rats from
Rediscovering our roots: 1934
chewing and harming those goods.
The roots of our Agrochemicals Business go back to 1934, when we started manufacturing the soil fumigant chloropicrin. In 1956, we formed a technical tie-up with the Swiss firm J.R. Geigy Ltd. (now " Sukima " of tomorrow: microcapsule
Syngenta AG) and began domestic production of the insecticide diazinon at our Oji Pharmaceutical Plant. It was reported that a line of trucks formed around the plant to get the product. These two Our microcapsule chemical technology is a first for agri- chemicals were the basis for a variety of products designed for cultural chemicals in Japan. Controlling the capsule size different uses and are still used on farms today.
and strength and the rate at which chemicals leach out makes it possible to tailor agents to targeted pests.
Agrochemicals Business ■Agrochemical Business products
We offer agricultural chemicals that bring together our production technology
and know-how and meet the needs of the times.

Insecticide DIAZINON CS "DIAZINON SL SOL"
Japan's first microencapsulated agricultural chemical. It has long-lasting effectiveness and
is highly safe.
Soil fumigant CHLOROPICRIN EC "CHLOPIC FLOW"
This improved new chemical mixes chloropicrin, which is hard to handle by itself, with
water, resulting in a product that is easy to process with less irritation when processing
but has stable effectiveness.
Successive innovations have led to other products such as CYCLOPROTHRIN
Supporting Food and Agriculture
G "CYCLO PACK" (a labor-saving insecticide that spreads by itself), spltNPV
WP "HASUMON TENTEKI" (a biological pesticide using a virus that selec-

Without food, there would be no life. The farm is where food is produced. tively infects insects), and WIDE COAT (a new type of adjuvant that improves
both spreadability and sticking power of agricultural chemicals).

The world's population is rising rapidly and demand for food is growing globally. Thus our world needs a safe and stable supply of food we can Insecticides for public health
count on into the future. This requires agrochemicals that are good for the We offer chemicals to protect from hygiene pests like flies, mosquitoes, cockroaches,
environment and suited for today's agricultural patterns, which include ticks and mites.
older farmers and people working side jobs. Using our fine chemicals exper- Insecticide PROPETAMPHOS CS "SAFROTIN MC"
tise, we develop, manufacture and sell insecticides, fungicides, herbicides, Safrotin, which has long been used to protect form hygiene pests, now comes in microcapsule soil fumigants, plant growth regulators and insecticides for public health, form. It has long-lasting effectiveness and is highly safe. It is particularly effective against cock-roaches, since the capsules break down the special structure of their digestive tracts.
among others. By supplying chemicals that meet the needs of the times, we support people's lifestyles.
Animal repellent R-731
This animal repellent contains microcapsules of capsaicin, the sharp-tasting compo-
nent of chili peppers. Kneaded into cables and other goods, it prevents rats from
Rediscovering our roots: 1934
chewing and harming those goods.
The roots of our Agrochemicals Business go back to 1934, when we started manufacturing the soil fumigant chloropicrin. In 1956, we formed a technical tie-up with the Swiss firm J.R. Geigy Ltd. (now " Sukima " of tomorrow: microcapsule
Syngenta AG) and began domestic production of the insecticide diazinon at our Oji Pharmaceutical Plant. It was reported that a line of trucks formed around the plant to get the product. These two Our microcapsule chemical technology is a first for agri- chemicals were the basis for a variety of products designed for cultural chemicals in Japan. Controlling the capsule size different uses and are still used on farms today.
and strength and the rate at which chemicals leach out makes it possible to tailor agents to targeted pests.
Resea rc h and
O u r C o re Te c h nologies
Develo pme nt S ystem
Our vast accumulation of technologies holds
There is no "sukima,"
our current business.
between our research centers.
At Nippon Kayaku's core are technologies of fine chemicals, which we have built up in the Our Research & Development Group brings together our management resources and R&D fields of explosives, dyes and pharmaceuticals (all of which derived from our original prod- functions. We have a research and development system that demonstrates our Group's collec- ucts) along with resins (a field we entered later), among others. With these core technolo- tive strength by fusing our various technologies and intellectual properties. Also, through co- gies, and new technologies created through their fusions, we have been conceiving new operation within and beyond the Group, we incorporate leading technologies and strengthen products and businesses. We will continue to strengthen, expand and fuse our core tech- our core technologies. As part of this effort, we use a system of "corporate themes" that nologies to create new products that meet the needs of the times.
seeks to generate new businesses and products as we conduct R&D Group-wide.
Intel ectual
and Fusion
Center for
New gas-generating agents
Research &
micro gas generators
・Polarizing film
・Optical functional film

・Inkjet printer ink dye
○Functional Chemicals R&D Laboratories
Using technologies learned from years of Our accumulated technology, which has As the research and development depart- The Pharmaceuticals Research Laborato- explosives and detonator manufacturing, changed based on needs of the times, ment of the Functional Chemicals Group, ries specialize in research and develop- we are undertaking the chal enge of devel- has evolved to a high level and is now the Functional Chemicals R&D Laboratories ment of anti-cancer drugs as well as in oping new technologies. Based on those used in colorants for inkjet printer inks, are involved in a variety of research and peripheral areas, such as in their R&D of technologies, we have developed automo- and for the color filters of digital camer- development areas, including resins, colo- polymeric micelle anti-cancer drugs using tive safety devices that require timing con- as and other products.
rants, films, catalysts and new materials that nanotechnology and development of trol at the mil isecond level.
derive from these.
generic anti-cancer drugs.
○Safety Systems Development Laboratories
By fusing our low-molecular synthesis By combining our Dye technology with The Safety Systems Development Labora- In order to contribute to an abundant technology developed in the pharmaceu- technology built up through the develop- tories develop automotive safety devices and safe food supply we can rely on, the tical field with our high polymer technol- ment of various resins, we have created a such as airbag inflators that instantly Agrochemicals Laboratories conduct ogy established through the development number of new products such as polariz- inflate airbags and micro gas generators R&D on environmentally friendly agro- of resins, we have created new "Polymeric ing films and optical functional films.
that create force to retract seatbelts chemicals, new agrochemical agents and micelle anti-cancer drugs," which are currently undergoing clinical trials.
Resea rc h a nd
O u r C o re Te c h nologies
Develo pme nt S ystem
Our vast accumulation of technologies holds
There is no "sukima,"
our current business.
between our research centers.
At Nippon Kayaku's core are technologies of fine chemicals, which we have built up in the Our Research & Development Group brings together our management resources and R&D fields of explosives, dyes and pharmaceuticals (all of which derived from our original prod- functions. We have a research and development system that demonstrates our Group's collec- ucts) along with resins (a field we entered later), among others. With these core technolo- tive strength by fusing our various technologies and intellectual properties. Also, through co- gies, and new technologies created through their fusions, we have been conceiving new operation within and beyond the Group, we incorporate leading technologies and strengthen products and businesses. We will continue to strengthen, expand and fuse our core tech- our core technologies. As part of this effort, we use a system of "corporate themes" that nologies to create new products that meet the needs of the times.
seeks to generate new businesses and products as we conduct R&D Group-wide.
Intel ectual
and Fusion
Center for
New gas-generating agents
Research &
micro gas generators
・Polarizing film
・Optical functional film

・Inkjet printer ink dye
○Functional Chemicals R&D Laboratories
Using technologies learned from years of Our accumulated technology, which has As the research and development depart- The Pharmaceuticals Research Laborato- explosives and detonator manufacturing, changed based on needs of the times, ment of the Functional Chemicals Group, ries specialize in research and develop- we are undertaking the chal enge of devel- has evolved to a high level and is now the Functional Chemicals R&D Laboratories ment of anti-cancer drugs as well as in oping new technologies. Based on those used in colorants for inkjet printer inks, are involved in a variety of research and peripheral areas, such as in their R&D of technologies, we have developed automo- and for the color filters of digital camer- development areas, including resins, colo- polymeric micelle anti-cancer drugs using tive safety devices that require timing con- as and other products.
rants, films, catalysts and new materials that nanotechnology and development of trol at the mil isecond level.
derive from these.
generic anti-cancer drugs.
○Safety Systems Development Laboratories
By fusing our low-molecular synthesis By combining our Dye technology with The Safety Systems Development Labora- In order to contribute to an abundant technology developed in the pharmaceu- technology built up through the develop- tories develop automotive safety devices and safe food supply we can rely on, the tical field with our high polymer technol- ment of various resins, we have created a such as airbag inflators that instantly Agrochemicals Laboratories conduct ogy established through the development number of new products such as polariz- inflate airbags and micro gas generators R&D on environmentally friendly agro- of resins, we have created new "Polymeric ing films and optical functional films.
that create force to retract seatbelts chemicals, new agrochemical agents and micelle anti-cancer drugs," which are currently undergoing clinical trials.
Message from the President
Aiming to be No. 1 globally in niche markets.
The Nippon Kayaku Group will be 100 years old in In the highly information-based society we now At Nippon Kayaku Group, our Corporate Vision is 2016. With everyone's generous support, we have "K AYAKU spirit." K AYAKU spirit, which means
stayed in business this long and cemented our repu- minute, and a company must be able to respond "Continuously providing society with the best prod- tation by innovating for a changing society and mar- quickly at the global level. The Nippon Kayaku ucts through ceaseless progress and the combined ketplace, which has enabled us to provide the best forces of our consciences," is what the Nippon products meeting the needs of the times. We will ideas." This signifies our desire to respond accu- Kayaku Group is called to be. Our wish is to fulfill continue to closely follow market needs as we seek to rately to the world's rapid changes and fuse our our economic, social and environmental responsibil- provide the best products.
diverse technologies with other technologies in ities and live up to all our shareholders' expecta- The Nippon Kayaku Group does business in many and b eyond the Nipp on Kayaku Group to pro - tions by always conducting our business in ways to areas based on our core technologies: explosives, vide products that only we could make and to be achieve KAYAKU spirit.
dyestuffs, pharmaceuticals and resins. As times have No. 1 globally in niche markets. We additionally Thank you for your ongoing support.
changed, new areas have replaced old ones as our core businesses, and we have continued to grow. In the meantime, with the innovation of Nippon Kayaku fields, into which we are concentrating manage- Group employees working in our various businesses, ment resources. We are rapidly developing our we have created and provided society with products that the constantly changing market requires.
that the world needs.
apan:Explosive td.:D o., L ear:Pharm o., L stablish K alaysia Sdn. Bhd. in M nflators:Inflator t crylic aenko:Catalyst t ippon Kxplosives m he D rganizations m LEO Began andustrial e Established T Received tgiven t Established Kayapola Co., Ltd.:Polarizing plate technology (Later established POLATECHNO CO., LTD. in 1991) currently W Com or f Established Kayaku Safety System Message from the President
Aiming to be No. 1 globally in niche markets.
The Nippon Kayaku Group will be 100 years old in In the highly information-based society we now At Nippon Kayaku Group, our Corporate Vision is 2016. With everyone's generous support, we have "K AYAKU spirit." K AYAKU spirit, which means
stayed in business this long and cemented our repu- minute, and a company must be able to respond "Continuously providing society with the best prod- tation by innovating for a changing society and mar- quickly at the global level. The Nippon Kayaku ucts through ceaseless progress and the combined ketplace, which has enabled us to provide the best forces of our consciences," is what the Nippon products meeting the needs of the times. We will ideas." This signifies our desire to respond accu- Kayaku Group is called to be. Our wish is to fulfill continue to closely follow market needs as we seek to rately to the world's rapid changes and fuse our our economic, social and environmental responsibil- provide the best products.
diverse technologies with other technologies in ities and live up to all our shareholders' expecta- The Nippon Kayaku Group does business in many and b eyond the Nipp on K ayaku Group to pro - tions by always conducting our business in ways to areas based on our core technologies: explosives, vide products that only we could make and to be achieve KAYAKU spirit.
dyestuffs, pharmaceuticals and resins. As times have No. 1 globally in niche markets. We additionally Thank you for your ongoing support.
changed, new areas have replaced old ones as our core businesses, and we have continued to grow. In the meantime, with the innovation of Nippon Kayaku fields, into which we are concentrating manage- Group employees working in our various businesses, ment resources. We are rapidly developing our we have created and provided society with products that the constantly changing market requires.
that the world needs.
apan:Explosive td.:D o., L ear:Pharm o., L stablish K alaysia Sdn. Bhd. in M nflators:Inflator t crylic aenko:Catalyst t ippon Kxplosives m he D rganizations m LEO Began andustrial e Established T Received tgiven t Established Kayapola Co., Ltd.:Polarizing plate technology (Later established POLATECHNO CO., LTD. in 1991) currently W Com or f Established Kayaku Safety System O r g aniz atio n (as of July 1, 2015)
Corporate Planning Division Public Relations & Investor Relations DivisionSecretarial Division R&D Planning Division Center for Innovative Research Intellectual Property Division Functional Chemicals R&D Laboratories Pharmaceutical Research Laboratories Executive Directors Safety Systems Development LaboratoriesAgrochemicals Laboratories Planning & Coordination Division (Managing Directors and above) Functional Materials Division Color Materials Division Catalysts DivisionFukuyama Plant / Asa Plant / Tokyo Plant West Japan Branch Crisis Management Planning & Coordination Division Pharmaceuticals Marketing Division Specialty Chemicals & International Division Disclosure Committee Diagnostics Dept.
Quality & Pharmacovigilance Division Pharmaceuticals Technical Operations Division Environment, Safety, Quality Assurance Pharmaceutical Development Division Management Committee Business Development DivisionTakasaki Plant Energy Conservation & East Japan Branch / West Japan Branch Prevention Committee Planning & Coordination DivisionMarketing Division Research & Development Technical Division Management Committee Agrochemicals DivisionKashima PlantWest Japan Branch Human Resources Management Division Purchasing Division Legal & General Affairs Division  Security Trade Control Dept.
Finance & Accounting Division Information Systems Division Quality Assurance Division C o r po rate Profile
Technical Administration & Engineering Division Environmental Protection & Safety Division Nippon Kayaku Co., Ltd.
Tokyo Business Center Masanobu Suzuki, President Internal Control Management Division 14,932 million yen Head Office Address Meiji Yasuda Seimei Building 19th and 20th Floors, 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo 100-0005, Japan http://w w w.nipponkayaku.co.jp/english/ MicroChem Corp.
■INDET SAFETY SYSTEMS a.s.
THE GILMORE ROAD PROPERTY, LLC ■■Nippon Kayaku Korea Co., Ltd.
■Shanghai KAYAKU International Trading Co., Ltd.
■Moxtek, Inc.
■Kayaku (Shanghai) Co., Ltd.
■■Euro Nippon Kayaku GmbH ■■NIPPON KAYAKU AMERICA, INC.
■Dejima Tech B.V.
■Wuxi Polatechno Optics Co., Ltd.
■Dejima Optical Films B.V.
■KAYAKU CHEMICAL (WUXI) CO., LTD.
■Wuxi Advanced Kayaku Chemical Co., Ltd.
■Polatechno (Hong Kong) Co., Ltd.
■Kayaku Safety Systems de Mexico, S.A. de C.V.
■Kayaku Safety Systems (Huzhou) Co., Ltd.
■■Taiwan Nippon Kayaku Co., Ltd.
■Kayaku Safety Systems Malaysia Sdn. Bhd.
From "sukima" to the World and a New Future: Nippon Kayaku production bases Sapporo Pharmaceutical Office Functional Chemicals Business
"Hishou" (training center) Nagoya Pharmaceutical Office Development Laboratories Sendai Pharmaceutical Office POLATECHNO CO., LTD.
(NIPPONKAYAKU FUKUYAMA CO., LTD.) (NIPPON KAYAKU TOKYO CO., LTD.) Kyoto Pharmaceutical Kanazawa Pharmaceutical Takasaki Pharmaceutical Office FUKUYAMA CO., LTD.
West Japan Branch ■Okiura Golf Center Osaka Pharmaceutical ■POLATECHNO CO., LTD.
"Hishou" (training center) ■NIPPON KAYAKU FOOD Hiroshima Pharmaceutical TECHNO CO., LTD.
■Gunnan Sangyo Co., Ltd.
Omiya Pharmaceutical Office MicroChem Corp.
Functional Chemicals Wuxi Advanced Kayaku R&D Laboratories (WUXI) CO., LTD.
Chemical Co., Ltd.
Tokyo Business Center Safety Systems Business
Functional Chemicals R&D ■Kouwa Sangyo Co., Ltd.
■KAYAKU AKZO CORPORATION, East Japan Branch Tokyo Pharmaceutical Office Co., Ltd., Asa Plant Pharmaceutical Research ■NIPPON KAYAKU TOKYO CO., LTD.
NIPPON KAYAKU FOOD TECHNO INDET SAFETY SYSTEMS a.s.
Kobe Pharmaceutical NIKKA FINE TECHNO CO., LTD.
NAC Co., Ltd.
Yokohama Pharmaceutical Takamatsu Pharmaceutical ■Tumor Diagnosis Support Fukuoka Pharmaceutical Office 1 ■Sanko Kagaku Kogyo Fukuoka Pharmaceutical Office 2 ■Wako Toshi Kaihatsu Co., Ltd.
■JHMS Co., Ltd.
■KAYAKU AKZO CORPORATION■Kayaku Japan Co., Ltd.
Functional Chemicals Business Pharmaceuticals Business Safety Systems Business Agrochemicals Business Others □Group companies Kayaku Safety Systems Kayaku Safety Systems de Kayaku Safety Systems (Huzhou) Co., Ltd.
Mexico, S.A. de C.V.
Malaysia Sdn. Bhd.
MicroChem Corp.
■INDET SAFETY SYSTEMS a.s.
THE GILMORE ROAD PROPERTY, LLC ■■Nippon Kayaku Korea Co., Ltd.
■Shanghai KAYAKU International Trading Co., Ltd.
■Moxtek, Inc.
■Kayaku (Shanghai) Co., Ltd.
■■Euro Nippon Kayaku GmbH ■■NIPPON KAYAKU AMERICA, INC.
■Dejima Tech B.V.
■Wuxi Polatechno Optics Co., Ltd.
■Dejima Optical Films B.V.
■KAYAKU CHEMICAL (WUXI) CO., LTD.
■Wuxi Advanced Kayaku Chemical Co., Ltd.
■Polatechno (Hong Kong) Co., Ltd.
■Kayaku Safety Systems de Mexico, S.A. de C.V.
■Kayaku Safety Systems (Huzhou) Co., Ltd.
■■Taiwan Nippon Kayaku Co., Ltd.
■Kayaku Safety Systems Malaysia Sdn. Bhd.
From "sukima" to the World and a New Future: Nippon Kayaku production bases Sapporo Pharmaceutical Office Functional Chemicals Business
"Hishou" (training center) Nagoya Pharmaceutical Office Development Laboratories Sendai Pharmaceutical Office POLATECHNO CO., LTD.
(NIPPONKAYAKU FUKUYAMA CO., LTD.) (NIPPON KAYAKU TOKYO CO., LTD.) Kyoto Pharmaceutical Kanazawa Pharmaceutical Takasaki Pharmaceutical Office FUKUYAMA CO., LTD.
West Japan Branch ■Okiura Golf Center Osaka Pharmaceutical ■POLATECHNO CO., LTD.
"Hishou" (training center) ■NIPPON KAYAKU FOOD Hiroshima Pharmaceutical TECHNO CO., LTD.
■Gunnan Sangyo Co., Ltd.
Omiya Pharmaceutical Office MicroChem Corp.
Functional Chemicals Wuxi Advanced Kayaku R&D Laboratories (WUXI) CO., LTD.
Chemical Co., Ltd.
Tokyo Business Center Safety Systems Business
Functional Chemicals R&D ■Kouwa Sangyo Co., Ltd.
■KAYAKU AKZO CORPORATION, East Japan Branch Tokyo Pharmaceutical Office Co., Ltd., Asa Plant Pharmaceutical Research ■NIPPON KAYAKU TOKYO CO., LTD.
NIPPON KAYAKU FOOD TECHNO INDET SAFETY SYSTEMS a.s.
Kobe Pharmaceutical NIKKA FINE TECHNO CO., LTD.
NAC Co., Ltd.
Yokohama Pharmaceutical Takamatsu Pharmaceutical ■Tumor Diagnosis Support Fukuoka Pharmaceutical Office 1 ■Sanko Kagaku Kogyo Fukuoka Pharmaceutical Office 2 ■Wako Toshi Kaihatsu Co., Ltd.
■JHMS Co., Ltd.
■KAYAKU AKZO CORPORATION■Kayaku Japan Co., Ltd.
Functional Chemicals Business Pharmaceuticals Business Safety Systems Business Agrochemicals Business Others □Group companies Kayaku Safety Systems Kayaku Safety Systems de Kayaku Safety Systems (Huzhou) Co., Ltd.
Mexico, S.A. de C.V.
Malaysia Sdn. Bhd.
From "Sukima" to the World and the Future Our technologies, born from "global ‘Sukima' ideas," may not always get a lot of attention.
However, these technologies support today's lifestyles and various industries and are laying a path to the future.
Count on the Nippon Kayaku Group to continue bringing forth supporting technologies from "sukima" to contribute to the world and the future.
From "Sukima" to the World and the Future Our technologies, born from "global ‘Sukima' ideas," may not always get a lot of attention.
However, these technologies support today's lifestyles and various industries and are laying a path to the future.
Count on the Nippon Kayaku Group to continue bringing forth supporting technologies from "sukima" to contribute to the world and the future.

Source: https://www.nipponkayaku.co.jp/company/information/pdf/guidance_en.pdf

stress.cl

Neuroscience 169 (2010) 98 –108 CHRONIC FLUOXETINE TREATMENT INDUCES STRUCTURALPLASTICITY AND SELECTIVE CHANGES IN GLUTAMATE RECEPTORSUBUNITS IN THE RAT CEREBRAL CORTEX E. AMPUERO,a F. J. RUBIO,a R. FALCON,a The selective serotonin reuptake inhibitor fluoxetine (flx) is M. SANDOVAL,a G. DIAZ-VELIZ,b R. E. GONZALEZ,a

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Healthcare & Beauty Channel Newsflash Pharmacies octobre 2015 Votre Healthcare & Beauty Channel Vainqueur du concours septembre: Prix de concours octobre: Madame Melanie Albert E-Reader Kindle Apotheke Dr. Guntern, 3900 Brig Paperwhite 6", WLAN Toutes nos félicitations!