Welsh pcg doc june 2003 a.w
Strategaeth Osteoporosis aAtaliad Torasgwrn i Gymru
Strategaeth Gofal Sylfaenol i Fyrddau Iechyd Lleol
Cynhyrchwyd gan y Gymdeithas Osteoporosis Genedlaethol
Osteoporosis andFracture PreventionStrategy for Wales
A Primary Care Strategyfor Local Health Boards
Produced by the National Osteoporosis SocietyJune 2003
Message from the Chief Medical Officer
"Osteoporosis is a ver y serious disease which results in 12,000 fractures in Waleseach year, causing severe pain and disability to individuals at a heavy cost to theWelsh Health Ser vice. But it is one of the few areas in which early inter vention topromote and maintain bone health can make a real impact on the burden of thedisease.
"I am delighted that the National Osteoporosis Society (NOS) has developed thisprimar y care strategy for osteoporosis and fracture prevention to help inform LocalHealth Boards (LHBs). The Society's ‘cradle to grave' strategy, involving manydifferent agencies, is an excellent example of the type of integrated approach thatis likely to be successful in the long-term."
Professor Ruth Hall
Chief Medical Officer
Message from the Minister for Health and Social Services
"This Osteoporosis and Fracture Prevention Strategy will assist and inform LocalHealth Boards (LHBs) working with the NHS trusts and social ser vices to addressthe rising tide of osteoporotic fractures in par ticular, reducing bed blockage. Thisapproach emphasises the prevention of osteoporotic fractures through thepromotion of a healthy active life and the prevention and treatment of osteoporosis.
The NOS strategy uses an evidence-based approach and links to national priorities,making it a wonder ful example of joined-up thinking.
"By tackling osteoporosis, LHBs have a real oppor tunity to improve the health oftheir patients through adopting a systematic approach within multi-agency teams."
Jane Hutt
Minister for Health and Social Ser vices
Executive Summar y
Introduction to the Osteoporosis and Fracture Prevention Strategy for Wales
An osteoporosis framework – meeting health needs
Which approach for primar y care?
Action plan for population-wide primar y prevention measures
Prevention of falls
Prevention and management of osteoporosis
selective case-finding 15
at which site to measure?
at what threshold to treat?
with what treatment?
Examples of selective case-finding 19
Is this strategy cost-effective?
Ser vice commissioning
Fur ther Resources
Osteoporosis and Fracture Prevention Strategy 3
Executive summaryKey recommendations are summarised below:
Include prevention of osteoporotic fractures in the local Health Improvement Programme (HIP).
Equality of access for diagnosis and treatment of osteoporosis for the people of Wales.
Identify lead clinicians in primar y and secondar y care to develop an osteoporosis programme based on thisstrategy:
each Local Health Board (LHB) should have a lead GP for osteoporosis, responsible for monitoring theimplementation of this programme.
each acute Trust should have a lead consultant for osteoporosis, responsible for clinical referrals,super vision of diagnostic ser vices and liaison with primar y care.
Establish a local osteoporosis interest group to facilitate multi-disciplinar y implementation of this framework.
Use a selective case-finding approach to target the treatment of individuals at high risk of osteoporoticfracture. This includes individuals with a histor y of previous fracture, frequent falls, use of oralglucocor ticosteroids or other clinical risk factors.
Provide access to adequate levels of diagnostic and specialist ser vices; thus a LHB ser ving a population of100,000 would require approximately 1,000 hip and spine DXA scans per year.
Promote the use of care pathways and audits to improve standards of care.
Monitor per formance to assess health impact.
Limit prescribing costs by targeting treatment at those for whom it is really necessar y and by identifyingthose treatments inappropriately prescribed.
This strategic document sets clear standards to enable LHBs to offer a high quality osteoporosis ser vice. LHBsmay wish to adopt a stepwise approach to its implementation, identifying which of the high risk groups detailedon pages 15-19 require immediate, medium and long-term action, and targeting resources as appropriate.
Crynodeb GweithredolCrynhoir yr argymhellion allweddol isod.
Cynnwys ataliad toresgyrn osteoporotig yn y Rhaglen Gwelliant Iechyd lleol.
Sicrhau cydraddoldeb hygyrchedd diagnosis a triniaeth osteoporosis i bobl Cymru.
Uniaethu clinigwyr ar weiniol mewn gofal sylfaenol ac eilaidd i ddatblygu rhaglen osteoporosis leol yn seiliedigar y strategaeth hon.
Dylai pob Bwrdd Iechyd Lleol gael Meddyg Teulu ar weiniol dros osteoporosis gyda chyfrifoldeb am gadwgweithrediad y rhaglen hon dan sylw.
Dylai pob Ymddiriedolaeth lem gael Meddyg Ymgynghorol dros osteoporosis gyda chyfrifoldeb amymgynghoriadau clinigol, goruchwyliad gwasanaethau diagnostig a chysylltiad â gofal sylfaenol.
Sefydlu gr wp lleol â diddordeb mewn osteoporosis i hyr wyddo gweithrediad amlddisgyblaethol y fframwaithhwn.
Defnyddio dull dethol o ddarganfod achosion er mwyn anelu triniaeth at unigolion mewn per ygl uchel.
Cynnwys hyn unigolion â hanes o dorasgwrn blaenorol, cwympiau aml neu defnydd steroidiau oral.
Darparu hygyrchedd lefelau digonol o wasanaethau diagnostig ac arbenigol; felly byddai angen oddeutu 1,000o archwiliadau amsugnometreg pelydr-X ynni deuol y flwyddyn ar Fwrdd Iechyd Lleol sy'n gwasanaethupoblogaeth o 100,000.
Hyr wyddo'r defnydd o lwybrau gofal ac archwiliad i wella safonau gofal.
Adolygu cyflawniad er mwyn asesu dylanwad ar iechyd.
Cyfyngu costau rhagnodi tr wy anelu triniaeth at y rhai sydd a'i angen ac uniaethu rheini â dderbyniasentragnodion anaddas.
Mae'r ddogfen strategol hon yn gosod safonau clir i alluogi Byrddau Iechyd Lleol i gynnig gwasanaethosteoporosis o ansawdd uchel. Efallai y bydd Byrddau Iechyd Lleol yn dymuno mabwysiadu dull cynyddol o'igweithredu, gan uniaethu pa fath o gleifion mewn per ygl uchel sydd angen gweithrediad yn y tymor byr, canoligneu hir ac anelu adnoddau fel bo angen.
Osteoporosis and Fracture Prevention Strategy
Osteoporosis and FracturePrevention Strategy for Wales
In
Our Healthier Nation1 the Secretar y of State for
Its recommendations arise from:
Health highlighted the role that osteoporosis plays in
an epidemiologically-based needs assessment,
causing fractures in older people, noting that, as aresult of this disease, falls are a major cause of death
ii) the health impact that action will have on
and disability. Osteoporosis prevention was therefore
individuals and population,
included as one of the measures recommended to
iii) a cost-effectiveness analysis,
achieve a 20% reduction in accidents by 2010.
iv) consideration of the feasibility of implementation.
To facilitate progress at a local level towards achieving
Activity stemming from this strategy can be
reductions in fracture incidence and implementation of
incorporated into LHB programmes for the care of
this, the National Osteoporosis Society (NOS) has
older people and for accident prevention under the
developed this osteoporosis strategy that should be
local Health Improvement Programme (HIP).
implemented by Local Health Boards (LHBs). The
Standards of ser vice provision identified in this
strategy offers practical advice for commissioners and
strategy relate to evidence-based clinical guidelines
providers to enable them to benchmark their current
recommended by the Royal College of Physicians
activity on osteoporosis and to identify how to improve
(RCP) (Royal College of Physicians, 1999)2, (Royal
health by investing in appropriate osteoporosis
College of Physicians and Bone and Tooth Society,
ser vices for a base population of 100,000.
2000)3 incorporated into LHB programmes for the careof older people and for accident prevention under thelocal HIP.
Osteoporosis and Fracture Prevention Strategy 5
An osteoporosis framework – meeting health needs
Implementation of an osteoporosis framework offers an appropriate andeffective means of improving the health and health-related quality of life forolder men and women.
Health and social needs
Health Evidence Bulletin in Wales PhysicalDisability and Discomfor t,
Osteoporosis November
Osteoporotic fractures are a major cause of pain,
disability and death.
Royal College of Physicians, Bone and Tooth
More than 12,000 osteoporotic fractures occur
Society of Great Britain, National Osteoporosis
each year in Wales5.1.
Society. Glucocor ticoid-induced osteoporosis.
There are over 4,200 hip fractures each year in
Guidelines for prevention and treatment, 200216.
7% of people suffering hip fracture die in hospitalwithin 30 days5.3, and 25% die within the following
Wide variations in clinical recognition of
Half of those sur viving hip fracture fail to regain
osteoporosis and related fractures.
their pre-fracture level of independence7.
Wide variation in access to diagnostic and
In Wales5.1 the care of people with hip fractures
specialist ser vices and in prescribing patterns.
alone leads to a total cost to Health and Social
Range of therapeutic inter ventions now viable but
Ser vices of £84 million each year.
concerns regarding inappropriate prescribing.
Fracture incidence and resulting costs will rise by
Limited inter vention among high-risk individuals to
over 1% per year, simply as a consequence of the
prevent future fracture17.
ageing of the Welsh population8.
Clear standards of evidence for interventions andservice delivery
Identify lead clinicians in primar y and secondar ycare to develop an osteoporosis programme based
Depar tment of Health. Repor t: Advisor y Group
on this strategy:
Repor t on Osteoporosis. 19949.
– each Local Health Board (LHB) should have a
Audit Commission. United They Stand. HMSO
lead GP for osteoporosis responsible for
monitoring the implementation of this
National Osteoporosis Society. Guidelines for the
provision of a clinical bone densitometr y ser vice.
– each acute trust should have a lead consultant
for osteoporosis, responsible for clinical
Depar tment of Health. Repor t on Health and Social
referrals, super vision of diagnostic ser vices and
Subjects 49. Nutrition and Bone Health: with
liaison with primar y care.
par ticular reference to calcium and vitamin D.
Establish a local osteoporosis interest group to
facilitate multi-disciplinar y implementation of this
Depar tment of Health. Strategy for Osteoporosis.
Health Ser vice Circular 124. 199813.
Use a selective case-finding approach to target the
Depar tment of Health. Local Health Action Sheet
treatment of individuals at high risk of osteoporotic
fracture. This includes individuals with a histor y of
Royal College of Physicians. Osteoporosis: clinical
previous fracture, frequent falls or use of oral
guidelines for prevention and treatment. 19992.
Royal College of Physicians, Bone and Tooth
Provide access to adequate levels of diagnostic
Society of Great Britain. Osteoporosis: clinical
and specialist ser vices; thus a LHB ser ving a
guidelines for prevention and treatment. Update on
population of 100,000 would require approximately
pharmacological inter ventions and an algorithm for
1,000 hip and spine DXA scans per year.
management. 20003.
Promote the use of care pathways and audits toimprove standards of care.
Monitor per formance to assess health impact.
Equality of access for diagnosis and treatment ofosteoporosis for the people of Wales.
Osteoporosis and Fracture Prevention Strategy
Resource implications
Performance indicators
Population-wide primar y prevention measures
Per formance indicators in this health care area
mainly involve health education and are relatively
have been proposed by this strategy:
Incidence of fractured femur.
Bone density measurement offers good value for
Deaths following fractured femur.
money to ensure appropriate prescribing: costs
Rate of discharge to normal place of residence
var y, with most falling between £30 and £60, less
within 28 days of admission with fractured neck
than the cost of three months' prescription of the
least expensive second generation
Rate of deaths in hospital within 30 days of
admission with a hip fracture for patients
Approximately 1,000 DXA scans per year would be
required for a population of 100,000 (see page
Propor tion of older people exhibiting high risk
for osteoporotic fracture, but without any injur y
Prescribing costs are likely to increase but cost-
to their bones, referred for assessment of bone
effective inter ventions are available and clinical
density (BMD) and offered appropriate
assessment with bone densitometr y should be
therapeutic inter ventions.
used to target treatment at those who will benefit
Reducing osteoporotic fractures features in the
‘Oppor tunities and Potentials' of the FracturedNeck of Femur Collaborative, one of theOr thopaedic Ser vices Collaborative programmesunder the umbrella of the NHS ModernisationAgency:
All fracture patients presenting in A&E to beassessed for osteoporosis treatment.
All ambulator y patients residing in residentialhomes to be prescribed calcium and vitamin D.
Table 1 on page 8 illustrates indicators for themanagement of osteoporosis in primar y care.
Osteoporosis and Fracture Prevention Strategy 7
Table 1: Indicators for the management of osteoporosis
DOMAINS OF PERFORMANCE
PERFORMANCE INDICATORS
Health Improvement Programme (HIP)
Age and sex-standardised incidence rates for osteoporosis fracture
Equality of access
Referral rates for DXA scans by general practice
to hip and spine DXA (DXA) scans
Audit of prescribing patterns by general practice
to appropriate therapeutic inter ventions
Rate of discharge within 28 days following hip fracture
to good rehabilitation following fractures
Rate of re-admission for fur ther fracture
Effective deliver y of appropriate health care, ie
known to be clinically effective and appropriate
Local implementation of RCP clinical guidelines and
referrals for DXA scans
complies with standards
prescribing in high risk groups
ser vice organisation
Waiting times for DXA within 3 monthsPropor tion of older people with risk factors for fracture,or previous fragility fracture, who are referred forassessment of bone mineral density (BMD) and/oroffered appropriate inter ventionsIncidence of fractured neck of femur
Cost of DXA scansCost of fracture management per patient
Patient/carer experience
Waiting times for referral for diagnostic ser vices orspecialist consultationPropor tion of operations for fracture repair carried out within 24 hours of admission by experienced staff Access to information and advice on prevention and long-term managementRate of discharge to normal place of residence within28 days of admission with a fractured neck of femur for patients aged 65+
Health outcomes of NHS care:
Percentage of people in high-risk groups given
reduction in risk of fracture
preventive advice
optimised function and improved quality of life
Percentage of people followed up after fracture
and treated to reduce future risk
reduction of falls ‘risk'
Percentage of people given information about self-care
reduction of premature death
Percentage of people given information aboutosteoporosis and details of the NOSPercentage of people returned to pre-injur y residenceand level of independence prior to fracturePercentage of people with hip fracture operated onwithin 24 hours of admissionStandardised mor tality rates for hip fractureRate of deaths in hospital within 30 days of admissionwith a hip fracture for patients aged 65+Propor tion of frail or housebound elderly who areassessed for fall risk and given calcium and vitamin Dand/or hip protectors
Osteoporosis and Fracture Prevention Strategy
Current annual expenditure incurred in managing fractures related to osteoporosis issummarised in Table 2.
Table 2: Estimated annual expenditure on fracturemanagement in a Local Health Board (LHB) of 100,000 patients
PREDICTED NUMBER
PER LOCAL HEALTH
# Of the 200 patients with x-ray evidence of ver tebral fractures 40 come to clinical attention and are costed.
The oppor tunity cost of not taking action to prevent fractures is clearly considerable. The cost of implementingthis ser vice strategy will var y according to local unit costs for diagnostic ser vices, professional educationrequirements, extent of generic prescribing and whether patient costs are included. An illustration is given onpage 23. From a societal perspective, fracture prevention will yield significant improvements in quality of life,such as the ability to maintain independent living. It will also reduce demand on social ser vices. In addition,reducing the cost of acute care for osteoporotic fractures will save scarce health care resources.
Osteoporosis and Fracture Prevention Strategy 9
Which approach for primary care?
Preventive strategies for reducing the incidence of falls and osteoporotic fracturesneed to include measures which target:
the whole population – lifestyle inter ventions
the individual – selective case-finding
Osteoporosis is defined as a progressive systemic
individual are still being developed21 and will enable
skeletal disease characterised by low bone mass and
determination of absolute rather than relative risk and
microarchitectural deterioration of bone tissue, with a
be related to a time inter val (for example 10 years).
consequent increase in bone fragility and susceptibility
Fur thermore, the addition of bone densitometr y to the
to fracture18. In Wales this results in over 12,000
identification of these risk factors enhances fracture
osteoporotic fractures each year, causing severe pain
risk prediction. Current national and international
and disability to individual patients and at an annual
guidelines therefore propose a number of clinical
cost to the Welsh health and social care budget of
indicators for bone densitometr y3 in which
more than £84 million4. More than one third of adult
measurement can aid clinical decision-making and
women and 1 in 12 adult men will sustain one or
also permit more cost effective use of
more osteoporotic fractures in their lifetime4,6.
pharmacological inter ventions to arrest bone loss.
Fracture risk depends ultimately on the strength of
bone and propensity to trauma. The relative
a. previous fragility fracture (forearm fractures
contributions of each of these to fracture
increase the risk of subsequent hip fractures by
pathogenesis varies, even at the three commonest
about 50%22; 20% of people who sustain a
sites at which fractures occur: the hip; wrist and
ver tebral fracture have another within a year23)
ver tebral body. Thus, almost all wrist fractures areassociated with a fall, while less than 25% of all
b. radiographic evidence of ver tebral deformity or
ver tebral fractures follow such a fall19. Approaches to
prevention include population-based strategies and
c. untreated hypogonadism (premature menopause,
those targeted to people at the highest risk2. Possible
secondar y amenorrhoea, primar y hypogonadism in
measures to reduce fracture risk in the general
women; primar y or secondar y hypogonadism in
population include increasing the level of physical
activity under taken at all ages, reducing the
d. treatment with oral glucocor ticosteroids (ie
prevalence of smoking and increasing dietar y calcium
prednisolone) for 3 months or more16
intake. Epidemiological studies have shown, with
e. diseases associated with an increased prevalence
var ying degrees of cer tainty, that these risk factors
are associated with osteoporosis. But there is little
sporadic risk factors, such as low body mass index
evidence about the effect of these population
and a family histor y of fracture.
inter ventions on fracture risk from randomisedcontrolled trials and therefore uncer tainty about the
Approaches to the prevention and treatment of falls
practical outcome of implementing them on a large
and osteoporotic fractures include population-based
scale. Among high-risk strategies, there is no clear
strategies and those targeted at individuals at highest
evidence that population-wide screening using bone
densitometr y to identify those at greatest risk iseffective in reducing fracture incidence. The major
Prevention and early detection of osteoporosis
thrust for prevention should therefore be directedtowards case-finding.
1. Action Plan for primar y prevention measures forosteoporosis (Population-wide approach)
Assessment of fracture risk in an individual shouldideally be expressed as absolute rather than relative
The Royal College of Physicians guidelines (1999)2
risk and be related to a time inter val (for example 10
repor ts that possible measures to reduce fracture risk
years). Bone densitometr y has been shown to predict
in the general population include increasing the level
absolute fracture risk20, in studies of populations
of physical activity under taken at all ages, reducing
independently of other risk factors for fracture (most
the prevalence of smoking and increasing dietar y
impor tantly, age; previous fragility fracture;
calcium intake. Epidemiological studies have shown,
glucocor ticosteroid use and untreated hypogonadism).
with var ying degrees of cer tainty, that these lifestyle
Methods of assessment of fracture risk in an
modifications may help reduce osteoporosis. But there
Osteoporosis and Fracture Prevention Strategy
is little evidence about their effect on fracture risk
from randomised controlled trials. The RCP repor t
Peak bone mass is under genetic control26. However, a
therefore made no recommendations concerning such
number of factors, from conception to skeletal
maturity, determine the extent to which this genetic
The most comprehensive approach to finding patients
potential is achieved. These include: hormonal status;
at high risk of future fracture would entail population-
weight-bearing physical activity; nutritional status and
wide screening using an effective investigation and
lifestyle attributes such as smoking and alcohol
inter vention in those at the highest risk. However, this
intake. Many of these factors also influence the rate
is not justifiable because there is no trial-based
of bone loss in later life. Preventive strategies should
evidence that such a programme using bone
focus on modifying these factors.
densitometr y, biochemical markers of bone turnover or
LHBs have an oppor tunity to integrate health
risk factor profiling is effective in fracture reduction
promotion and health care at the individual and
nor that such an inter vention is cost-effective. For this
population level thanks to their links with other
reason, the RCP repor t recommended that the major
agencies. On the basis of clinical and
thrust of prevention should be directed towards
cost-effectiveness, it is recommended that lifestyle
selective case-finding (the oppor tunistic identification
measures* to develop and maintain bone health
of high risk patients against predetermined criteria,
throughout life are included in health promotion
who are then offered bone densitometr y).
activities since there is synergy with messages forprevention of other chronic diseases, while a selective
2. Selective case-findng
case-finding approach is adopted to target individualsat high absolute risk of fracture.
In the absence of current evidence to suppor t apopulation-wide screening strategy, a selective case-
Oppor tunities for population-wide health promotion and
finding strategy has been recommended by all national
the input required from relevant agencies are identified
and international collaborations to examine this issue
in the following action plan. Fur ther details regarding
(The World Health Organisation24, International
case-finding at the individual level are given on pages
Osteoporosis Foundation25, the American Society for
15-21. The prevention and treatment of osteoporosis
Bone Mineral Research and the Royal College of
requires a collaborative approach between primar y,
Physicians2). Using the selective case-finding strategy,
secondar y and community care and between health
patients are identified, measured and treated because
and social ser vices. Identifying key contacts within
of a fragility fracture or by the presence of strong risk
different agencies and involving them in a local
osteoporosis interest group will promote inter-sectoralworking and help to ensure a strategic approach to theidentification of local priorities and the development oflocal osteoporosis ser vices. In addition to the work ofhealth and social ser vices, local radio and newspapersmay also act as useful media for promoting bonehealth messages.
*See Table 3 on page 12 for fur ther details
Osteoporosis and Fracture Prevention Strategy 11
Table 3:Action plan for primary prevention measures for osteoporosis(This will also benefit other disease areas such as coronary heart disease and diabetes)
Maternal well-being
Primar y health care team*
Ante- and post-natal contacts
Child sur veillance programme
Oppor tunistic advice
sunshine exposureAdequate weight-bearing activity
Include bone health and accident
prevention messages in health
behaviour initiatives
Health promotion ser viceLeisure centresSocial ser vicesPrimar y health care team
Health promotion ser vice
Health promoting schools
Education Authority
sunshine exposure
Design regular weight-bearing
Adequate weight-bearing
activity into school curriculum
activityAvoidance of smoking
School catering staff
Provide calcium-rich school meals
Caution about excessive
School milk scheme
dieting and athletic amenorrhoea
Include regular weight-bearingactivity into school curriculum
Information on excessivedieting and nutrition
Primar y health care team
Oppor tunistic information
Oppor tunistic information
Clubs/voluntar y agencies
Oppor tunistic information
Women with amenorrhoea
Primar y health care team
Investigate and refer
Oppor tunistic information during
consultations, e.g.
contraceptive carecer vical screeningante-natal care
Oral glucocor ticosteroid use
Evaluate risk of osteoporosis/
refer to secondar y care
Include bone health and accident
sunshine exposure
prevention messages in health
Adequate weight-bearing
behaviour initiatives
activityAvoidance of smoking
Occupational health
Raise awareness of bone health
Caution about excessive
Promote and advise on regular
dieting and athletic
weight-bearing activity
Oppor tunistic information
recommended safe limits
Clubs/voluntar y agencies
Osteoporosis and Fracture Prevention Strategy
Adults at mid-life
Primar y health care team
Menopause/Well Woman clinics
Oral glucocor ticosteroid
and oppor tunistic counselling
Refer for DXA and treat accordingto current glucocor ticosteroidguidelines
Include bone health and accident
prevention messages in health
sunshine exposure
behaviour initiatives
Adequate weight-bearing activity
Promote and advise on regular
Avoidance of smoking
weight-bearing activity
Caution about excessive dieting
Occupational health
Provide advice to female staff
on the menopause and advise
recommended safe limits
both men and women on healthyliving and risk of osteoporosis
Encourage adherence topharmacological treatment
Clubs/voluntar y agencies
Osteoporosis prevention
Primar y health care team
Selective case finding for patients
at highest risk of osteoporoticfracture and initiationof appropriate treatment
Falls prevention
Include falls risk assessment
and advise on safe andindependent living in health checks for 75+
Include bone health and accidentprevention messages in healthbehaviour initiatives
Ensure patients understand theirmedication and adhere todosage regimes
Oral glucocor ticosteroid
Primar y health care team
Offer bone health advice
Occupational therapists
Healthy dietAdequate safe sunshine
Nursing and residential
Regularly re-assess patients/
homes/social ser vices
residents on osteoporosis/
Adequate weight-bearing
Review measures to promote
Avoidance of smoking
good nutrition and exercise
Alcohol withinrecommended safe limits
Offer advice on specific exercises
Clubs/voluntar y agencies
*Including: GPs, Practice Nurses, District Nurses, Health Visitors, Midwives, Physiotherapists,
Occupational Therapists and Health Promotion Ser vice
The National Osteoporosis Society is a valuable source for patient and professional literature promoting a healthy lifestyle.
Osteoporosis and Fracture Prevention Strategy 13
Prevention of falls
As with osteoporosis, strategies to reduce the frequency of falls in elderly peoplemay be aimed either at the entire population or at high risk individuals.
Epidemiological studies have clearly identified important risk factors for falls inelderly people27. Intrinsic risk factors include problems with walking (reducedbalance, gait and muscle strength); use of multiple medications (particularly thoseleading to sedation and reduced blood pressure), and impairment of vision ormemory. Extrinsic factors include poor lighting, unsafe stairs, loose rugs, poorlyfitting footwear or clothing, and the lack of safety equipment. The reduction offalls should lead to a reduction in fractures.
The NHS provides an administrative frameworkwhereby general health screening for the identification
Population-based preventive strategies are par ticularly
of risk factors for falls and systematic inter vention
well placed to reduce fall frequency by encouraging
with a multi-dimensional series of components could
regular weight-bearing physical activity among elderly
easily be incorporated in primar y and secondar y care.
people (which also increases bone mineral density
Indeed a study from Australia suggested a GP health
(BMD) and reduces fractures), encouraging the
education programme could significantly improve the
identification of impor tant risk factors through general
well being of elderly patients in their care30.
health screening, and reducing the prevalence of poly-pharmacy and environmental hazards among the
International guidelines have now been developed
elderly (especially among the institutionalised
jointly by the British and American Geriatrics Societies
and the American Society of Or thapaedic Surgeonswhich provide evidence-based strategies31.
High risk approaches
Multi-faceted inter ventions reduce falls in olderpeople and therefore fractures
This strategy for the prevention of falls in those at
Assessment and appropriate referral of high risk
high risk of falling and fracturing is suppor ted by a
nursing home residents is effective
prospective randomised controlled trial from theUnited States29. A multi-dimensional assessment and
Home assessment of older people at risk of falls
inter vention was offered to people identified as being
needs to be accompanied by direct inter vention or
at risk of falls. This achieved a reduction in annual fall
appropriate referral
incidence of 12% compared with a control sample.
Comprehensive assessment and modification of
Extrapolation from this study suggested that it was
risk factors is effective when offered to community
relatively cost-effective, but its sample size precluded
dwelling older people who have presented to an
assessment of health outcomes other than falls (for
accident and emergency depar tment after a fall32
example, fracture or all cause mor tality).
The provision of hip protectors to residents ofnursing homes is effective if they have had
A randomised controlled trial of multi-dimensional
previous fractures33
inter ventions to those at the highest risk carried out inthe UK suppor ted these findings. The key components
It is essential that clear referral pathways for the
of the inter vention in these studies are:
assessment and management of osteoporosis areintegral to such ser vices.
(a) medication reviews
It is recommended that an approach is based on
(b) balance and gait training
collaboration between primar y care teams and
(c) weight-bearing exercise and
specialists in the medicine of old age.
(d) improvement in functional skills
A similar integrated approach to the management offalls risk will be crucial if effective fracture preventionstrategies are to be developed in Wales.
Osteoporosis and Fracture Prevention Strategy
Prevention and management of osteoporosis
Selective case-finding
Case-finding may occur in both primar y and secondar y
Most DXA scanning units provide guidelines on
care although long-term management is mainly the
appropriate referral that conform to national
responsibility of primar y care teams. Referral for bone
guidelines. DXA is recommended for individuals with
density measurement of hip and spine (DXA) should
key clinical risk factors to confirm whether treatment is
be considered in those who are at increased risk of
required2. Table 4 indicates the groups of people who
osteoporosis and therefore of fracture and where the
may be considered for diagnostic DXA scan.
result is likely to change clinical management.
Table 4: Referral criteria for bone density measurement
TARGET HIGH RISK GROUP
ANNUAL ESTIMATED NUMBER OF SCANS PER 100,000 POPULATION*
Men and women with:
previous low trauma fracture
x-ray evidence of osteopenia
glucocor ticosteroid use(ie. prednisolone for three months or more)
family histor y of osteoporosis(especially maternal hip fracture)
other clinical risk factors:height loss, kyphosis, low BMI (<19 kg/m2)
possible secondar y osteoporosis, primar y hyperparathyroidism,rheumatoid ar thritis, liver disease, alcoholism,primar y hypogonadism
untreated oestrogen deficiency(surgical or natural menopause <45 years,secondar y amenorrhoea > 6 months not due to pregnancy,primar y hypogonadism)
many centres also utilise DXA scanning to monitor therapeutic response
*Data assembled from a national NOS sur vey34 and from Dr N Peel, Osteoporosis Centre, University of Sheffield
Osteoporosis and Fracture Prevention Strategy 15
At which site to measure?
At what threshold to treat?
Bone density measurement by hip and spine DXA
DXA results are conventionally repor ted according to
(DXA) remains the "gold standard" for the diagnosis of
the number of standard deviations by which a reading
patients with osteoporosis, although the spine may
differs from the young adult mean (T score)2.
also be a suitable site for diagnosis in younger people
Instruments also provide information on the number of
without evidence of osteoar thritis35. If spine and
standard deviations by which a reading differs from
proximal femur bone density measurements are not
the age-specific mean (Z score). Table 5 shows a
available, a measurement of forearm or calcaneal
simple classification of hip and/or spine DXA scan
bone density by DXA can be used but interpretation of
results and indicates when treatment is
results must be evaluated carefully to identify those at
recommended. Current guidelines recommend that
risk of fracture as diagnostic inter vention thresholds
treatment decisions should be based on clinical
may differ with these technologies. Quantitative
assessment in addition to T scores. Z scores may be
ultrasound in common with DXA must have stringent
useful in determining management of cer tain patients;
quality assurance and can be used in the assessment
appropriate guidance should be provided by the local
of fracture risk, but not for the diagnosis of
bone densitometr y ser vice or lead clinician.
osteoporosis36. This is currently an area of activeresearch and the NOS will continue to update itsposition statements on the use of these peripheralbone density techniques36,37.
Table 5: Indications for management*
HIP OR SPINE DXA T-SCORE
Normal T> -1.0 SD
Low bone mass (osteopenia)
Falls preventionOffer treatment if previousfragility or ver tebral fracture:See Table 7 on page 17
Osteoporosis T < -2.5 SD
Lifestyle adviceFalls prevention and offertreatment as detailed on pages 17–18
*Derived from Royal College of Physicians (1999)2
With what treatment?
Several inter ventions are now available which retardbone loss, reduce fracture risk and are licensed forthe prevention and/or treatment of osteoporosis. Lackof comparative data makes it difficult to recommendspecific treatments based on a hierarchy of efficacy orclinical effectiveness.
Evidence suppor ting the use of specific treatment issummarised extensively in the Royal College ofPhysicians update 20003. Tables 6 and 7 on the nextpage are a tabulation of this evidence.
Osteoporosis and Fracture Prevention Strategy
Table 6: Effect of interventions on the prevention/reduction of postmenopausal bone loss: grade of recommendations
Cessation of smoking
Cyclic etidronate
Physical exercise
Reduced alcohol consumption
Vitamin D + calcium
Table 7: Anti-fracture efficacy of interventions in postmenopausal osteoporotic women: grade of recommendations
NON-VERTEBRAL HIP
Cyclic etidronate
Physical exercise
Raloxifene A nd nd
nd: not demonstratedA
Meta analysis of Randomised Controlled Trials (RCTs) or from at least one RCT
From at least one other type of well designed quasi-experimental studyFrom well-designed non-experimental descriptive studies, eg. comparative studies, correlation studies, case-control studies
From exper t committee repor ts/opinions and/or clinical experience of authorities
Osteoporosis and Fracture Prevention Strategy 17
Summar y statements on the treatment of
All patients commencing pharmacological therapy
osteoporosis with various inter ventions are listed
should also be counselled on lifestyle measures to
reduce bone loss including: weight-bearing physicalactivity; nutritional status and lifestyle attributes such
Bisphosphonates: Alendronate and risedronate
as smoking and alcohol intake.
prevent bone loss at all sites vulnerable toosteoporosis and decrease the risk of spine and
Advice regarding smoking cessation and safe drinking
hip fracture. Cyclical etidronate reduces bone loss
should always be given, not only because there is
at the spine in women with osteoporosis and
good evidence that these behaviours can increase the
reduces the risk of ver tebral fracture.
risk of osteoporosis but also because, as with all the
Calcium supplements of 1g or more daily decrease
modifiable lifestyle factors, there is secondar y gain in
bone loss in elderly women but the effects are
other areas such as coronar y hear t disease and
less marked than those of HRT or the
bisphosphonates. Calcium in combination with
The National Osteoporosis Society is a valuable
vitamin D has also been shown to reduce the hip
source for patient and professional literature
fracture rate. It is impor tant to note that calcium
promoting a healthy lifestyle.
and vitamin D were used in addition to therapy inthe bisphosphonate and raloxifene studies, eitherfor all par ticipants, or where dietar y/lifestyle
Examples of selective case-finding
information suggested less than optimal levels.
Patients at risk of osteoporosis may present in both
This may have contributed to the beneficial effects
primar y and secondar y care, hence the need for a
in these studies.
collaborative approach to identify appropriate patients
Oestrogen (HRT) prevents bone loss; its effects
and to agree subsequent management policies. Table
are dose dependent. Ver tebral and hip fracture
8 provides some examples of oppor tunities for
frequency decrease while on treatment.
identifying patients at high risk of osteoporosis. Audits
Obser vational studies indicate potential protective
of computer records to identify such patients offer a
effects on distal forearm fractures. Anti-fracture
more systematic approach. The National Osteoporosis
efficacy will wane on cessation of treatment38.
Society (NOS) holds examples of validated audit
Nasal Calcitonin prevents bone loss, reduces
protocols which are available on request.
ver tebral fracture frequency but there is no trial-based evidence that it prevents fractures atother sites.
SERMs (selective estrogen receptor modulator):Raloxifene has been shown to increase bonedensity at the spine and hip in women with lowbone density (osteopenia and establishedosteoporosis) and decrease the risk of ver tebral(but not hip) fracture.
Testosterone and anabolic steroids have beenshown to prevent bone loss in men and olderpeople respectively but adequate studies have notbeen per formed to examine their effect againstfracture.
Vitamin D metabolites (calcitriol and alfacacidol)retard bone loss and some studies havedemonstrated an effect against ver tebral fracture;but not hip fracture. There is some evidence thatreplacement of vitamin D insufficiency may reducefalls via an enhancement of neuromuscular and/orpsychomotor per formance.
Osteoporosis and Fracture Prevention Strategy
Table 8: Examples of opportunities for selective case-finding
Patients with previous
a. Hospital falls & fracture clinic:
Inform primar y care team of need for
fragility fracture
advise patient of possible
osteoporosis risk and inform
Encourage patient to visit GP for
primar y care team of need for
osteoporosis advice and follow-up
b. Encourage patient to visit GP
c. Offer advice to patient during
rehabilitation after hip fracture
d. Primar y care audit of records
Consider need for diagnostic evaluationof osteoporosis and/or referral to falls ser vice
Patients on oral
a. On initiation of
Warn of possible osteoporosis risk
glucocor ticosteroids
glucocor ticosteroid treatment
b. In hospital outpatient depar tment
Refer for densitometr y and treat
or during general practice
according to RCP guidelines on
glucocor ticosteroid inducedosteoporosis16
c. On prescription review for
Review dose of glucocor ticosteroid
patients already prescribed
Offer general lifestyle advice and
glucocor ticosteroids
a. Residential/Nursing homes
Consider osteoporosis risk and need for
and house-bound elderly
calcium and vitamin D supplements
Consider falls prevention and use of hip protectors
Osteoporosis and Fracture Prevention Strategy 19
Figure 1: Medical management of men and women aged over45 years who have or are at risk of osteoporosis
Frail, increased fall
Previous fragility
risk +/- housebound
[DXA, hip +/- spine]
T score -1 to -2.5
T score below -2.5
Treat if previous
Offer treatment**
Calcium + vitamin D*
For men aged less than 65 years, specialist referral should be considered.
Recommended daily dose 0.5-1g and 800iu respectively.
Treatments listed in alphabetical order. Calcium and vitamin D aregenerally regarded as adjuncts to treatment. HRT: oestrogen inwomen, testosterone in hypogonadal men.
*** Calcium and vitamin D should be offered as adjunctive therapy
BMD: bone mineral density
DXA: dual energy x-ray absorptiometr y
HRT: hormone replacement therapy
†† see page 21
††† see page 21
Osteoporosis and Fracture Prevention Strategy
Below is an explanation of Figure 1 featured on
Bone and liver function tests (Ca, P, alk phos,
Major risk factors (other than previous fragility
fracture – a fracture sustained from a fall from
standing height or less) include the following:
1. Untreated hypogonadism (premature menopause,
2º amenorrhoea, 1º hypogonadism in women; 1º
or 2º hypogonadism in men).
2. Glucocor ticosteroids (prednisolone for 3 months
Lateral thoracic and lumbar spine x-rays.
Serum paraproteins and urine Bence Jones
3. Disease associated with increased prevalence of
osteoporosis (eg, gastrointestinal disease, chronic
Isotope bone scan.
liver disease, hyperparathyroidism,
Serum FSH if hormonal status unclear (women).
hyper thyroidism).
Serum testosterone, LH and SHBG (men).
4. Radiological evidence of ver tebral deformity or
Other risk factors in national and international
Adequate nutrition especially with calcium and
guidelines include family histor y, low body weight,
cigarette smoking, height loss or low bone mass asassessed by other techniques.
Regular weight-bearing activity.
Avoidance of tobacco use or alcohol abuse.
†Previous fragility fracture
Defined as a fracture sustained from a fall fromstanding height or less and includes prevalentver tebral deformity. A previous fragility fracture is astrong independent risk factor for fur ther fracture andmay be regarded as an indication for treatmentwithout the need for BMD measurement when theclinical histor y is unequivocal.
Derived from Royal College of Physicians.
Osteoporosis: Clinical guidelines for prevention and treatment update. RCP (2000)3
Osteoporosis and Fracture Prevention Strategy 21
Is this strategy cost-effective?
1. Population-wide: bone health promotion
There are current health promotion activities in which
Prescribing costs can be limited by using clinical
osteoporosis bone health messages could be
assessment and bone density measurement to
included, such as Hear t Health campaigns.
identify individuals at greatest risk of fracture who willderive greatest benefit from treatment and by
Patient information leaflets and other educational
identifying those who are being treated inappropriately
resources are available from the National
and whose treatment can be discontinued.
2. Referral for hip and spine DXA (DXA)
The cost-effectiveness of bone densitometr y dependsupon the costs of treatment, targeted on the basis ofthe results: the more expensive the inter vention, thegreater the cost-effectiveness of bone density referraland measurement. It is not cost effective to measureBMD where treatment costs less than £100 perannum, for example calcium and vitamin D2.
Meeting clinical governance requirements
Assessing standards of care for all those with or at
The RCP Clinical Guidelines (1999/2000)2,3 provide
risk of osteoporosis requires clear process and
standards for clinical care. Standards for ser vice
outcome indicators as well as effective tools for
configuration which will enable such care to be
monitoring per formance. The key per formance
provided are outlined for secondar y care in
Guidelines
indicators are summarised on page 7.
for the provision of a clinical bone densitometr yser vice11 and for primar y care in this osteoporosis
The major objective is fracture reduction, and it is
strategy. Standards for falls prevention and
impor tant that LHBs are able to access local fracture
management ser vices are given in the joint British and
data. Hip fracture data is available through the Patient
American Geriatric Societies Guidelines31. The NOS
Episode Database for Wales (PEDW) and the All Wales
has examples of audit protocols which focus on
Injur y Sur veillance System (AWISS). Currently wrist
management of high-risk groups such as patients
and ver tebral fractures are poorly recorded. LHBs may
being prescribed oral glucocor ticosteroids, that can be
wish to liaise with their local acute providers to identify
used by LHBs to assess their per formance against
what local data are available. Ver tebral fractures are
these standards.
commonly under-repor ted but this is in par t becauseonly approximately one-third come to clinical attention.
Benefits in fracture reduction may be seen within oneyear, par ticularly if inter ventions are aimed at thoseaged over 65.
Osteoporosis and Fracture Prevention Strategy
Service commissioning
LHBs may wish to adopt a stepwise approach to the implementation of anosteoporosis strategy, identifying which of the high-risk groups require immediate,medium or long-term action, and targeting resources appropriately. Initially, as atemporary measure, LHBs may want to adopt a few of the steps below beforeproviding a full osteoporosis service.
The following indicates the annual cost that might be incurred in providing the ser vice framework forosteoporosis as outlined. It is viewed from the perspective of a LHB ser ving a population of 100,000 and willvar y according to local unit costs.
Identification of a lead clinician(s) for osteoporosis
in secondar y care and a lead GP for the LHB
GP time to par ticipate in local district-wide interest group,
implement framework and monitor per formance: 1 GP session per week (£110 plus NI) plus travel expenses
Population-wide bone health promotion
(absorbed within ongoing health promotion activity)
Referral for hip and spine DXA (approximately 1,000 scans
assuming a cost of £50) (The actual cost of DXA scans varies)
Access to specialist exper tise on treatment for established osteoporosis
1 par t-time osteoporosis nurse to assist with case finding 16,000
Prescribing costs (500 patients @ average drug cost of £170
per patient with 4 GP consultations per year)
This ser vice would cost the same as managing 9 out of the 145 hip fractures which occur in a population of100,000 per year39 (see Table 2 on page 9).
Osteoporosis and Fracture Prevention Strategy 23
Further resources
For health professionals
For fur ther information on the government's strategyfor osteoporosis please see:
National Osteoporosis Society (NOS) literature:
Depar tment of Health website:
Examples of audit protocols which have been
effectively piloted by GP practices targeting:
For fur ther information on glucocor ticoid-induced
all high risk groups
osteoporosis please see:
women after hysterectomy
oral glucocor ticosteroid patients
Royal College of Physicians, Bone and Tooth Society ofGreat Britain, National Osteoporosis Society.
NOS position statements:
Glucocor ticoid-induced osteoporosis. Guidelines for
The use of peripheral x-ray absorptiometr y in the
prevention and treatment. 2002
management of osteoporosis
The use of quantitative ultrasound in the
management of osteoporosis
The NOS has a wide range of literature for the public,
Guidelines for the provision of a clinical bone
which may be useful for health promotion activity. Its
density ser vice
telephone helpline offers confidential advice on the
The repor ting of dual-energy x-ray absorptiometr y
treatment and prevention of osteoporosis, and
bone mineral density scans
membership offers practical and continuing suppor t to
Examples of NOS patient information – fur ther leaflets
people with osteoporosis.
To obtain fur ther information, please contact:
Osteoporosis – causes, prevention and treatment
National Osteoporosis Society
Coping with a broken hip
Six steps to healthy bones
tel: 01761 471771
Healthy bones for all the family
fax: 01761 471104
helpline: 0845 450 0230
e-mail: [email protected]
Living with osteoporosis – coping after broken
website: www.nos.org.uk
The NOS has worked with many LHBs to develop and
The National Osteoporosis Society would like to thank
implement local osteoporosis strategies – please
the International Osteoporosis Foundation for their
contact the NOS if you require fur ther information:
assistance with this document.
Angela JordanActing Health Ser vices Liaison ManagerNational Osteoporosis SocietyCamer tonBath BA2 0PJ
tel: 01761 471771fax: 01761 471104
Professional helpline(staffed by osteoporosis nurses): 0845 450 0230
This document was based on a document producedfor England.
email: [email protected]: www.nos.org.uk
The National Osteoporosis Society (NOS) wishes tothank members of the NOS Scientific Advisor y Groupwho assisted in the production of this document, withpar ticular thanks to Professor David Barlow, Dr PamBrown, Professor Cyrus Cooper, Professor RichardEastell, Professor Graham Russell, Professor CameronSwift and Dr David Torgerson.
Osteoporosis and Fracture Prevention Strategy
Depar tment of Health. Saving Lives: Our Healthier Nation. Depar tment of Health 1999.
Royal College of Physicians. Osteoporosis: clinical guidelines for prevention and treatment. RCP 1999.
Royal College of Physicians and Bone and Tooth Society of Great Britain. Osteoporosis: Clinical guidelinesfor prevention and treatment. Update on pharmacological inter ventions and an algorithm for management.
RCP London 2000.
Torgerson DJ, Iglesias CP, Reid DM. The economics of fracture prevention. In The Effective Management ofOsteoporosis; 111-21 2001.
5.1. Johansen A, Evans R, Stone MD, Richmond P, Lo SV, Woodhouse KW. The incidence of fracture in the
United Kingdom: a study based on the population of Cardiff. Injur y; 28: 655-660 1997.
5.2. Patient Episode Database for Wales (PEDW) 1997-1999. Health Solutions Wales, 1999.
Welsh Office: Clinical Indicators for the NHS, 1995-1998. Welsh Office, 1999.
Cooper C, Epidemiology of Osteoporosis, Osteoporosis International, Supplement 2, S2-S8. 1999.
Eddy DM, Johnson CC, Cummings SR, Dawson-Hughes B, Lindsay R, Melton LJ, and Slemenda CWOsteoporosis: review of the evidence for prevention, diagnosis, treatment and cost-effectiveness analysis.
Osteoporosis International 8 (Supplement 4). 1998.
Burge RT, Worley D, Johansen A, Bhattachar yya S, Bose U. The Cost Of Osteoporotic Fractures In TheUnited Kingdom: Projections for 2000-2020. J. Medical Economics 2001;4:51-62
Depar tment of Health. Advisor y Group Repor t on Osteoporosis. Depar tment of Health 1994.
Audit Commission. United they stand. HMSO 1995.
National Osteoporosis Society Guidelines for the Provision of a Clinical Bone Densitometr y Ser vice. NOS 2002.
Depar tment of Health. Repor t on Health and Social Subjects 49. Nutrition and Bone Health: with par ticularreference to calcium and vitamin D. HMSO 1998.
Depar tment of Health. Strategy to prevent and tackle osteoporosis. Health Ser vice Circular 124 1998.
Preventing Accidents Caused by Osteoporosis. Local Health Action Sheet. Depar tment of Health 1998.
Health Evidence Bulletin in Wales Physical Disability and Discomfor t, Osteoporosis November 2001.
Royal College of Physicians, Bone and Tooth Society of Great Britain, National Osteoporosis Society.
Glucocor ticoid-induced osteoporosis. Guidelines for prevention and treatment, 2002.
Torgerson DJ, Dolan P. Prescribing by general practitioners after an osteoporotic fracture. Ann Rheum Dis;57(6):378-9 1998.
Consensus Development Conference. Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med; 94 646-50 1993.
Melton III LJ, Cooper C, "Osteoporosis", (Marcus R, Fetham D, Kelsey J, ed.) 2nd Edition 2001, Chapter21, Volume 1 557-567
Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predictoccurrence of osteoporotic fractures. BMJ; 312(7041): 1254-9 1996.
Kanis JA, Johnell O, Oden A, Dawson A, De Laet C, Jonsson B. Ten year probabilities of osteoporoticfractures according to BMD and diagnostic thresholds. Osteoporosis International; 12(12): 989-95 2001.
Cuddihy MT, Gabriel SE, Crowson CS, O'Fallen WM, Melton LJ III. Forearm fractures as predictors ofsubsequent osteoporotic fractures. Osteoporosis International; 9:469-75 1999
Lindsay R, Silverman SL, Cooper C, Hanley DA, Bar ton I, Broy SB et al. Risk of new ver tebral fracture in theyear following a fracture. JAMA, Jan 17 vol 285, no. 3 2001.
Osteoporosis and Fracture Prevention Strategy 25
WHO. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis;technical repor t series 843. Geneva: WHO, 1994.
Kanis JA, Delmas P, Burckhardt P, Cooper C, Torgerson D. Guidelines for diagnosis and management ofosteoporosis. The European Foundation for Osteoporosis and Bone Disease. Osteoporosis International;7(4):390-406 1997.
Ralston SH. Osteoporosis. BMJ 315, 469-472. 1997.
Masud T, Morris RO. Epidemiology of falls. Age & Ageing 2001; 30 (Suppl 4):3-7. Primar y Care Strategy forOsteoporosis and Falls.
Campbell, AJ et al. Randomised Controlled trial of a general practice programme of home based exerciseto prevent falls in elderly women, BMJ, 315, 1065-1069. 1997.
Tinetti ME, Baker DI, McAvay G, Claus EB, Garrett P, Gottschalk M et al. A multifactorial inter vention toreduce the risk of falling among elderly people living in the community. New England Journal of Medicine.
1994;331(13):821-7.
Kerse NM, Flicker L, Jolley D, Arroll B, Young D. Improving the health behaviours of elderly people:randomised controlled trial of a general practice education programme. [see comments.]. BMJ;319(7211):683-7 1999.
Guideline for the Prevention of Falls in Older Persons. American Geriatrics Society, British Geriatrics Societyand American Academy of Or thopaedic Surgeons Panel on Falls Prevention. JAGS; 49:664-672 2001.
Close J, Ellis M, Hooper R, Glucksman E, Jackson S, Swift C. Prevention of falls in the elderly trial (PROFET)– a randomised controlled trial. Lancet; 353:93-7 1999.
Lauritzen JB, Petersen MM, Lund B. Effect of external hip protectors on hip fractures. Lancet; 341:11-13 1993
Rowe RE, Cooper C. Osteoporosis ser vices in secondar y care: a UK sur vey. Journal Royal Society ofMedicine; 93: 22-24 2000.
Kanis JA, Gluer CC. An update on the diagnosis and assessment of osteoporosis with densitometr y.
Committee of Scientific Advisors, International Osteoporosis Foundation. Osteoporosis International; 11(3): 192-202 2000.
National Osteoporosis Society. Position statement on the use of quantitative ultrasound in the managementof osteoporosis. NOS 2001.
National Osteoporosis Society. Position statement on the use of peripheral x-ray absorptiometr y in themanagement of osteoporosis. NOS 2001.
Michaëlsson K, Baron JA et al. Variation in Efficiency of HRT in Prevalence of Hip Fracture. Osteoporosis International 8 540-546 1998.
Torgeson DJ, Iglesias CP, Reid DM. The Economics of Fracture Prevention (chapter). In The EffectiveManagement of Osteoporosis. Barlow DH, Francis RM, Miles A (eds) Aesculpius Medical Press, London 2001.
Osteoporosis and Fracture Prevention Strategy
Priorities for action
Key recommendations are summarised below:
Include prevention of osteoporotic fractures in the local HIP
Identify lead clinicians in primar y and secondar y care to develop an osteoporosis program based on thisstrategy:
each Local Health Board (LHB) should have a lead GP for osteoporosis , responsible for monitoring theimplementation of this program.
each acute trust should have a lead consultant for osteoporosis, responsible for clinical referrals,super vision of diagnostic ser vices and liaison with primar y care.
Establish a local osteoporosis interest group to facilitate multi-disciplinar y implementation of this framework.
Use a selective case-finding approach to target the treatment of individuals at high risk of osteoporoticfracture. This includes individuals with a histor y of previous fracture, frequent falls or use of oralglucocor ticosteroids.
Provide access to adequate levels of diagnostic and specialist ser vices; thus a LHB ser ving a population of100,000 would require approximately 1,000 hip and spine DXA scans per year.
Promote the use of care pathways and audits to improve standards of care.
Monitor per formance to assess health impact.
Equality of access for diagnosis and treatment of osteoporosis for the people of Wales.
This strategic document sets clear standards to enable LHBs to offer a high quality osteoporosis. LHBs maywish to adopt a stepwise approach to its implementation, identifying which of the high risk groups detailed onpages 15-19 require immediate, medium and long-term action, and targeting resources as appropriate.
The National Osteoporosis Society (NOS) wishes to thankmembers of the NOS Scientific Advisor y Group who assisted
in the production of this document. Par ticular thanks to :
Dr Par vaiz AliDr Andrew Borg
Dr Pam BrownDr Antony JohansenDr Phil Jones
National Osteoporosis Society
Camer ton, Bath BA2 0PJ
tel: 01761 471771
of the Writing Group of the Welsh Osteoporosis
fax: 01761 471104
Advisor y Group (WOAG)
professional helpline: 0845 450 0230
Thanks also to other members of WOAG:
website: www.nos.org.uke-mail: [email protected]
Ms Anne BeamesDr Wil D EvansMs Liz GreenDr Wyn HarrisDr Anthony JamesDr Jim Mar tinMs Julie MorganDr KT RajanDr Priscilla Williams
June 2003 National Osteoporosis Society All rights reser ved. No par t of this publication may be reproduced, stored in anyretrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or other wisewithout the prior permission of the copyright owner.
Registered charity number: 292660
Osteoporosis and Fracture Prevention Strategy 27
Osteoporosis and fracture prevention across the LHB
Identify primar y care lead
Set up local osteoporosis
Identify secondar y care
Local needs assessment
Collect baseline data:
Number with osteoporosis
DXA scans provided, the cost of the ser vice, and appropriateness of referrals if data available
Fracture data – hip, Colles, ver tebral fracture numbers and costs
Drug use and costs (calcium and vitamin D,bisphosphonates)
Agree selective case-finding strategy
Stratify high-risk target groups
Formulate and cost a care pathway
Multidisciplinar y falls
provision and cost-effectiveness
DXA needs and costs
Treatment guidance
Per formance indicators
Educate primar y care teams
Agree implementation plan and implement the care pathway
Source: http://www.injuryobservatory.net/wp-content/uploads/2012/08/Older-Strategy-2003-Osteoporosis-and-Fracture.pdf
Drugs 2012; 72 (17): 2187-2205 Adis ª 2012 Springer International Publishing AG. All rights reserved. Advances in Drug Development forAcute MigraineRyan J. Cady,1 Candace L. Shade2 and Roger K. Cady2 1 Center of Biomedical & Life Sciences, Missouri State University, Springfield, MO, USA2 Banyan Group, Inc., Springfield, MO, USA Triptans revolutionized medical recognition and the acute treatment of
Vol. 169, 592–596, February 2003 HE JOURNAL OF UROLOGY Printed in U.S.A. Copyright © 2003 by AMERICAN UROLOGICAL ASSOCIATION TERAZOSIN THERAPY FOR CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME: A RANDOMIZED, PLACEBO CONTROLLED TRIAL PHAIK YEONG CHEAH,* MEN LONG LIONG, KAH HAY YUEN, CHU LEONG TEH, TIMOTHY KHOR, JIN RONG YANG, HIN WAI YAP AND JOHN N. KRIEGER†